Pronunciation: per FEN a zeen
2 mg, round, gray, imprinted with 4940, V
4 mg, round, gray, imprinted with 4941, V
8 mg, round, gray, imprinted with 4942, V
16 mg, round, gray, imprinted with 4943, V
2 mg, round, white, imprinted with GG 18
4 mg, round, white, imprinted with GG 107
8 mg, round, white, imprinted with GG 108
16 mg, round, white, imprinted with GG 109
16 mg, round, gray, imprinted with SP 077
2 mg, rectangular, gray, imprinted with SP 705
4 mg, round, gray, imprinted with 4941 V
4 mg, round, gray, imprinted with SP 940
8 mg, round, gray, imprinted with 4942 V
8 mg, round, gray, imprinted with SP 313
4 mg, round, gray, imprinted with LOGO 940
8 mg, round, gray, imprinted with LOGO 313
You should not use perphenazine if you have liver disease, brain damage, bone marrow depression, a blood cell disorder, or if you are also using large amounts of alcohol or medicines that make you sleepy.
Perphenazine is not approved for use in older adults with dementia-related psychosis.
Call your doctor at once if you have twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. These could be early signs of dangerous side effects.
Perphenazine is a phenothiazine (FEEN-oh-THYE-a-zeen) anti-psychotic medicine.
Perphenazine is used to treat psychotic disorders such as schizophrenia. It is also used to control severe nausea and vomiting.
Perphenazine may also be used for purposes not listed in this medication guide.
You should not use this medicine if you are allergic to any phenothiazine (such as perphenazine, chlorpromazine, prochlorperazine, promethazine, o thioridazine), or if you have:
Perphenazine may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.
Tell your doctor if you have ever had:
Tell your doctor if you will be exposed to extreme heat or cold, or to insecticide poisons while you are taking perphenazine.
Tell your doctor if you are pregnant or you become pregnant. Taking antipsychotic medicine in the last 3 months of pregnancy may cause breathing problems, feeding problems, or withdrawal symptoms in the newborn.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
You will need frequent medical tests.
If you need surgery, tell your surgeon you currently use this medicine.
Do not stop using perphenazine suddenly, or you could have unpleasant symptoms such as nausea, vomiting, dizziness, or tremors. Ask your doctor how to safely stop using this medicine.
Store at room temperature away from moisture, heat, and light.
Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.
Avoid drinking alcohol. It can increase some of the side effects of perphenazine.
Avoid exposure to sunlight or tanning beds. Perphenazine can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
High doses or long-term use of perphenazine can cause a serious movement disorder that may not be reversible. The longer you use perphenazine, the more likely you are to develop this disorder, especially if you are a woman or an older adult.
Call your doctor at once if you have:
Side effects such as dry mouth, constipation, tremors, and drowsiness may be more likely in older adults.
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Taking perphenazine with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.
Many drugs can affect perphenazine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2021 Cerner Multum, Inc. Version: 9.01. Revision date: 4/24/2020.
Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.