pramipexole

Pronunciation: pram i PEX ole

Brand: Mirapex, Mirapex ER

Mirapex

slide 1 of 48, Mirapex,

0.75 mg, oval, white, imprinted with BI, 101

slide 1 of 48

Mirapex ER

slide 2 of 48, Mirapex ER,

0.375 mg, round, white, imprinted with ER, 0.375

slide 2 of 48

Mirapex ER

slide 3 of 48, Mirapex ER,

1.5 mg, oval, white, imprinted with ER, 1.5

slide 3 of 48

Mirapex ER

slide 4 of 48, Mirapex ER,

3 mg, oval, white, imprinted with ER, 3.0

slide 4 of 48

Mirapex ER

slide 5 of 48, Mirapex ER,

4.5 mg, oval, white, imprinted with ER, 4.5

slide 5 of 48

Mirapex

slide 6 of 48, Mirapex,

0.125 mg, round, white, imprinted with BI, 83

slide 6 of 48

Mirapex

slide 7 of 48, Mirapex,

0.25 mg, oval, white, imprinted with BI BI, 84 84

slide 7 of 48

Mirapex

slide 8 of 48, Mirapex,

0.5 mg, oval, white, imprinted with BI BI, 85 85

slide 8 of 48

Mirapex

slide 9 of 48, Mirapex,

1 mg, round, white, imprinted with BI BI, 90 90

slide 9 of 48

Mirapex

slide 10 of 48, Mirapex,

1.5 mg, round, white, imprinted with BI BI, 91 91

slide 10 of 48

Mirapex ER

slide 11 of 48, Mirapex ER,

0.75 mg, round, white, imprinted with ER, 0.75

slide 11 of 48

Mirapex ER

slide 12 of 48, Mirapex ER,

2.25 mg, oval, white, imprinted with ER, 2.25

slide 12 of 48

Pramipexole Dihydrochloride

slide 13 of 48, Pramipexole Dihydrochloride,

0.125 mg, round, white, imprinted with 91

slide 13 of 48

Pramipexole Dihydrochloride

slide 14 of 48, Pramipexole Dihydrochloride,

1.5 mg, round, white, imprinted with 9/5

slide 14 of 48

Pramipexole Dihydrochloride

slide 15 of 48, Pramipexole Dihydrochloride,

0.75 mg, round, yellow, imprinted with 84

slide 15 of 48

Pramipexole Dihydrochloride

slide 16 of 48, Pramipexole Dihydrochloride,

0.125 mg, round, white, imprinted with CL, 2

slide 16 of 48

Pramipexole Dihydrochloride

slide 17 of 48, Pramipexole Dihydrochloride,

0.25 mg, oval, white, imprinted with CL 3

slide 17 of 48

Pramipexole Dihydrochloride

slide 18 of 48, Pramipexole Dihydrochloride,

0.5 mg, oval, white, imprinted with CL 4

slide 18 of 48

Pramipexole Dihydrochloride

slide 19 of 48, Pramipexole Dihydrochloride,

1.5 mg, round, white, imprinted with CL 6

slide 19 of 48

Pramipexole Dihydrochloride

slide 20 of 48, Pramipexole Dihydrochloride,

1 mg, oval, white, imprinted with S G, 1 30

slide 20 of 48

Pramipexole Dihydrochloride

slide 21 of 48, Pramipexole Dihydrochloride,

0.125 mg, round, imprinted with SG, 126

slide 21 of 48

Pramipexole Dihydrochloride

slide 22 of 48, Pramipexole Dihydrochloride,

0.25 mg, oval, white, imprinted with S G, 1 27

slide 22 of 48

Pramipexole Dihydrochloride

slide 23 of 48, Pramipexole Dihydrochloride,

0.5 mg, oval, white, imprinted with S G, 1 28

slide 23 of 48

Pramipexole Dihydrochloride

slide 24 of 48, Pramipexole Dihydrochloride,

1 mg, oval, white, imprinted with SG, 1 30

slide 24 of 48

Pramipexole Dihydrochloride

slide 25 of 48, Pramipexole Dihydrochloride,

0.75 mg, oval, white, imprinted with Y, 44

slide 25 of 48

Pramipexole Dihydrochloride

slide 26 of 48, Pramipexole Dihydrochloride,

0.125 mg, oblong, pink, imprinted with P1

slide 26 of 48

Pramipexole Dihydrochloride

slide 27 of 48, Pramipexole Dihydrochloride,

0.25 mg, round, blue, imprinted with P2

slide 27 of 48

Pramipexole Dihydrochloride

slide 28 of 48, Pramipexole Dihydrochloride,

0.5 mg, oblong, lavender, imprinted with P3

slide 28 of 48

Pramipexole Dihydrochloride

slide 29 of 48, Pramipexole Dihydrochloride,

0.125 mg, round, white, imprinted with PX

slide 29 of 48

Pramipexole Dihydrochloride

slide 30 of 48, Pramipexole Dihydrochloride,

0.25 mg, oval, white, imprinted with PX 1

slide 30 of 48

Pramipexole Dihydrochloride

slide 31 of 48, Pramipexole Dihydrochloride,

0.5 mg, oval, white, imprinted with PX 2

slide 31 of 48

Pramipexole Dihydrochloride

slide 32 of 48, Pramipexole Dihydrochloride,

1 mg, oval, white, imprinted with PX 3

slide 32 of 48

Mirapex

slide 33 of 48, Mirapex,

0.125 mg, round, white, imprinted with 2, U

slide 33 of 48

Mirapex

slide 34 of 48, Mirapex,

0.25 mg, oval, white, imprinted with 4 4, U U

slide 34 of 48

Mirapex

slide 35 of 48, Mirapex,

0.5 mg, oval, white, imprinted with U U, 8 8

slide 35 of 48

Mirapex

slide 36 of 48, Mirapex,

1 mg, round, white, imprinted with U U, 6 6

slide 36 of 48

Mirapex

slide 37 of 48, Mirapex,

1.5 mg, round, white, imprinted with 37 37, U U

slide 37 of 48

Pramipexole Dihydrochloride

slide 38 of 48, Pramipexole Dihydrochloride,

0.125 mg, round, white, imprinted with b, C2

slide 38 of 48

Pramipexole Dihydrochloride

slide 39 of 48, Pramipexole Dihydrochloride,

0.25 mg, round, peach, imprinted with 9 2

slide 39 of 48

Pramipexole Dihydrochloride

slide 40 of 48, Pramipexole Dihydrochloride,

0.25 mg, oval, white, imprinted with b, C3

slide 40 of 48

Pramipexole Dihydrochloride

slide 41 of 48, Pramipexole Dihydrochloride,

0.5 mg, oval, white, imprinted with b, C4

slide 41 of 48

Pramipexole Dihydrochloride

slide 42 of 48, Pramipexole Dihydrochloride,

0.75 mg, oval, white, imprinted with 8019, TV

slide 42 of 48

Pramipexole Dihydrochloride

slide 43 of 48, Pramipexole Dihydrochloride,

1 mg, round, white, imprinted with b, C5

slide 43 of 48

Pramipexole Dihydrochloride

slide 44 of 48, Pramipexole Dihydrochloride,

1.5 mg

slide 44 of 48

Pramipexole Dihydrochloride

slide 45 of 48, Pramipexole Dihydrochloride,

1.5 mg, round, white, imprinted with b, C6

slide 45 of 48

Pramipexole Dihydrochloride ER

slide 46 of 48, Pramipexole Dihydrochloride ER,

1.5 mg, oval, white, imprinted with RDY, 613

slide 46 of 48

Pramipexole Dihydrochloride ER

slide 47 of 48, Pramipexole Dihydrochloride ER,

3 mg, oval, white, imprinted with RDY, 614

slide 47 of 48

Pramipexole Dihydrochloride ER

slide 48 of 48, Pramipexole Dihydrochloride ER,

4.5 mg, oval, white, imprinted with RDY, 615

slide 48 of 48

What is the most important information I should know about pramipexole?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What is pramipexole?

Pramipexole has some of the same effects as a chemical called dopamine, which occurs naturally in your body. Low levels of dopamine in the brain are associated with Parkinson's disease.

Pramipexole is used to treat symptoms of Parkinson's disease (stiffness, tremors, muscle spasms, and poor muscle control). Pramipexole is also used to treat restless legs syndrome (RLS).

Only immediate-release pramipexole (Mirapex) is approved to treat either Parkinson symptoms or RLS. Extended-release pramipexole (Mirapex ER) is approved only to treat Parkinson symptoms.

Parkinson's and RLS are two separate disorders. Having one of these conditions will not cause you to have the other condition.

Pramipexole may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking pramipexole?

You should not use pramipexole if you are allergic to it.

Tell your doctor if you have ever had:

low blood pressure;
dizziness after getting up too fast;
daytime drowsiness;
kidney disease; or
problems controlling your muscle movements.

People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Talk to your doctor about this risk and what skin symptoms to watch for.

It is not known whether pramipexole will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

It is not known whether pramipexole passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How should I take pramipexole?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

If you are taking immediate-release pramipexole (Mirapex) you should not take extended-release pramipexole (Mirapex ER) at the same time.

The dose and timing of pramipexole in treating Parkinson's disease is different from the dose and timing in treating RLS. Follow the directions on your prescription label. Ask your pharmacist if you have any questions about the kind of pramipexole you receive at the pharmacy.

Pramipexole can be taken with or without food. Take the medication with food if it upsets your stomach.

Do not crush, chew, or break an extended-release tablet (Mirapex ER). Swallow it whole.

If you are taking this medication for RLS, tell your doctor if your symptoms get worse, if they occur in the morning or earlier than usual in the evening, or if you feel restless symptoms in your hands or arms.

Do not stop using pramipexole suddenly, or you could have unpleasant withdrawal symptoms. Follow your doctor's instructions about tapering your dose.

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking pramipexole?

Do not drink alcohol. Dangerous side effects can occur when alcohol is combined with pramipexole.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

What are the possible side effects of pramipexole?

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Some people taking pramipexole have fallen asleep during normal daytime activities such as working, talking, eating, or driving. Tell your doctor if you have any problems with daytime sleepiness or drowsiness.

Call your doctor at once if you have:

a light-headed feeling, like you might pass out;
hallucinations (seeing or hearing things that are not real);
extreme drowsiness, falling asleep suddenly, even after feeling alert;
tremors, twitching or uncontrollable muscle movements;
unexplained muscle pain, tenderness, or weakness;
vision problems; or
posture changes you cannot control, such as involuntary bending forward of your neck, bending forward at the waist, or tilting sideways when you sit, stand, or walk.

Side effects such as confusion or hallucinations may be more likely in older adults.

You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs.

Common side effects may include:

muscle spasm or muscle weakness;
drowsiness, dizziness, weakness;
confusion, memory problems;
dry mouth;
nausea, constipation;
increased urination; or
sleep problems (insomnia), unusual dreams.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect pramipexole?

Using pramipexole with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your other medicines, especially:

cimetidine;
metoclopramide; or
medicine to treat mental illness, such as chlorpromazine, droperidol, fluphenazine, haloperidol, perphenazine, prochlorperazine, thioridazine, and others.

This list is not complete. Other drugs may affect pramipexole, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about pramipexole.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2020 Cerner Multum, Inc. Version: 8.01. Revision date: 6/11/2018.

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