Pronunciation: roe LA pi tant

Brand: Varubi

What is the most important information I should know about rolapitant?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What is rolapitant?

Rolapitant blocks the actions of chemicals in the body that trigger nausea and vomiting.

Rolapitant is used together with other medicines to prevent nausea and vomiting caused by cancer chemotherapy.

Rolapitant may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using rolapitant?

You should not use rolapitant if you are allergic to it.

Some medicines can cause unwanted or dangerous effects when used with rolapitant. Your doctor may need to change your treatment plan if you use any of the following drugs:

  • pimozide (Orap); or
  • thioridazine (Mellaril).

To make sure rolapitant is safe for you, tell your doctor if you have:

  • liver disease.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.

This medicine may affect fertility (your ability to have children) for a short time. Talk to your doctor if you have concerns about this.

It is not known whether rolapitant passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Rolapitant is not approved for use by anyone younger than 18 years old.

How should I use rolapitant?

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Rolapitant is usually given on Day 1 of your chemotherapy treatment, within 2 hours before the start of chemotherapy. Follow your doctor's instructions.

Rolapitant is given either as a tablet taken by mouth, or as an injection into a vein through an IV. A healthcare provider will give you a rolapitant injection.

You may take rolapitant tablets with or without food.

You should not take rolapitant tablets more than once every 14 days.

Rolapitant injection must be given slowly, and the infusion can take at least 30 minutes to complete.

You will be given other medication to prevent nausea or vomiting while you are taking rolapitant. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.

Store the tablets at room temperature away from moisture and heat.

What happens if I miss a dose?

The timing of your rolapitant dose is important for this medicine to be effective. Call your doctor if you forget to take the tablets or you do not receive the injection within 2 hours before your chemotherapy starts.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid after using rolapitant?

For at least 1 month after you use rolapitant, avoid using any cough or cold medicine that contains dextromethorphan. Talk to your doctor about how to best treat a cough due to the common cold.

What are the possible side effects of rolapitant?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • pain or burning when you urinate;
  • low red blood cells (anemia) --pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet; or
  • low white blood cell counts --fever, swollen gums, painful mouth sores, skin sores, cold or flu symptoms, cough, trouble breathing.

Common side effects may include:

  • hiccups;
  • mouth sores;
  • dizziness;
  • indigestion, stomach pain, loss of appetite; or
  • low blood cell counts.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect rolapitant?

Other drugs may interact with rolapitant, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your healthcare providers about your current medicines and any medicine you start or stop using. For at least 28 days after you use rolapitant, it could affect other medicines you are using.

Where can I get more information?

Your pharmacist can provide more information about rolapitant.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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