Home
Individuals and Families
Health and Wellness
Wellness Library
sulfasalazine

sulfasalazine

Pronunciation: SUL fa SAL a zeen

Brand: Azulfidine, Azulfidine EN-tabs, Sulfazine

Azulfidine EN-tabs

slide 1 of 7, Azulfidine EN-tabs,

500 mg, elliptical, gold, imprinted with KPh, 102

Image of Azulfidine EN-tabs
slide 1 of 7

SulfaSALAzine

slide 2 of 7, SulfaSALAzine,

500 mg, round, orange, imprinted with WATSON 796

Image of SulfaSALAzine
slide 2 of 7

SulfaSALAzine

slide 3 of 7, SulfaSALAzine,

500 mg, oval, yellow, imprinted with 104

Image of SulfaSALAzine
slide 3 of 7

SulfaSALAzine

slide 4 of 7, SulfaSALAzine,

500 mg, round, yellow, imprinted with G500

Image of SulfaSALAzine
slide 4 of 7

Azulfidine

slide 5 of 7, Azulfidine,

500 mg, round, gold, imprinted with KPh, 101

Image of Azulfidine
slide 5 of 7

Azulfidine EN-tabs

slide 6 of 7, Azulfidine EN-tabs,

500 mg, elliptical, gold, imprinted with KPh, 102

Image of Azulfidine EN-tabs
slide 6 of 7

SulfaSALAzine

slide 7 of 7, SulfaSALAzine,

500 mg, round, yellow, imprinted with MP 91

Image of SulfaSALAzine
slide 7 of 7

What is the most important information I should know about sulfasalazine?

You should not use sulfasalazine if you have porphyria, a blockage in your bladder or intestines, or if you are allergic to sulfa drugs, aspirin, or similar medicines called salicylates.

What is sulfasalazine?

Sulfasalazine is used to treat ulcerative colitis (UC), and to decrease the frequency of UC attacks. Sulfasalazine will not cure ulcerative colitis, but it can reduce the number of attacks you have.

Sulfasalazine is also used to treat rheumatoid arthritis in children and adults who have used other arthritis medicines that did not work or have stopped working.

Sulfasalazine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking sulfasalazine?

You should not use sulfasalazine if you are allergic to it, or if you have:

  • a blockage in your bladder or intestines;
  • porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system);
  • an allergy to sulfa drugs; or
  • an allergy to aspirin or other salicylates (such as Nuprin Backache Caplet, Kaopectate, KneeRelief, Pamprin Cramp Formula, Pepto-Bismol, Tricosal, Trilisate, and others).

Tell your doctor if you have ever had:

  • frequent infections;
  • asthma;
  • low blood cell counts; or
  • liver or kidney disease.

Tell your doctor if you are pregnant. Taking sulfasalazine can make it harder for your body to absorb folic acid, and folic acid helps prevent major birth defects of the baby's brain or spine. You may need to take folic acid supplements if you take sulfasalazine during pregnancy. Follow your doctor's instructions.

Sulfasalazine can pass into breast milk and may cause diarrhea or bloody stools in a nursing baby. Tell your doctor if you are breast-feeding.

Sulfasalazine is not approved for use by anyone younger than 2 years old.

How should I take sulfasalazine?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take this medicine after a meal.

Swallow the tablet whole and do not crush, chew, or break it.

You will need frequent medical tests.

Drink plenty of liquids to keep your kidneys working properly while you are taking sulfasalazine.

Sulfasalazine can affect the results of certain medical tests. Tell any doctor who treats you that you are using sulfasalazine.

Sulfasalazine may cause your skin or urine to appear orange-yellow in color. Call your doctor if you also have yellowing of your eyes, brown urine, or stomach pain. These may be signs of liver problems.

If you are treating arthritis, do not stop using any of your other arthritis medicines until your doctor tells you to. Sulfasalazine may not improve your symptoms right away, and you may still need your other medicines for awhile.

Sulfasalazine is only part of a complete treatment for rheumatoid arthritis that may also include rest and physical therapy. Follow your doctor's instructions very closely.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include vomiting, stomach pain, drowsiness, or seizure.

What should I avoid while taking sulfasalazine?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of sulfasalazine?

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

You may get infections more easily, even serious or fatal infections. Call your doctor right away if you have signs of infection such as:

  • fever, chills, sore throat;
  • mouth sores, red or swollen gums;
  • pale skin, easy bruising, unusual bleeding; or
  • chest discomfort, wheezing, dry cough or hack, rapid weight loss.

Also call your doctor at once if you have:

  • fever with headache, rash, and vomiting;
  • a skin rash, no matter how mild;
  • severe nausea or vomiting when you first start taking sulfasalazine;
  • little or no urination, urine that looks foamy;
  • puffy eyes, swelling in your ankles or feet, weight gain; or
  • liver problems --loss of appetite, stomach pain (upper right side), dark urine, jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • nausea, vomiting, upset stomach, loss of appetite;
  • headache;
  • rash; or
  • low sperm count in men.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect sulfasalazine?

Other drugs may affect sulfasalazine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about sulfasalazine.

This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

© 2019 Cigna. All rights reserved
Language Assistance

Disclaimer

Individual and family medical and dental insurance plans are insured by Cigna Health and Life Insurance Company (CHLIC), Cigna HealthCare of Arizona, Inc., Cigna HealthCare of Illinois, Inc., and Cigna HealthCare of North Carolina, Inc. Group health insurance and health benefit plans are insured or administered by CHLIC, Connecticut General Life Insurance Company (CGLIC), or their affiliates (see a listing of the legal entities that insure or administer group HMO, dental HMO, and other products or services in your state). Group Universal Life (GUL) insurance plans are insured by CGLIC. Life (other than GUL), accident, critical illness, hospital indemnity, and disability plans are insured or administered by Life Insurance Company of North America, except in NY, where insured plans are offered by Cigna Life Insurance Company of New York (New York, NY). All insurance policies and group benefit plans contain exclusions and limitations. For availability, costs and complete details of coverage, contact a licensed agent or Cigna sales representative. This website is not intended for residents of New Mexico.

 Selecting these links will take you away from Cigna.com to another website, which may be a non-Cigna website. Cigna may not control the content or links of non-Cigna websites. Details