Pronunciation: ten IP oh side

What is the most important information I should know about teniposide?

Teniposide can cause severe allergic reactions and may increase your risk of bleeding or infection. You may be given other medications to help prevent certain side effects or an allergic reaction.

What is teniposide?

Teniposide is used in combination chemotherapy to treat childhood acute lymphoblastic leukemia (a type of blood cancer).

Teniposide is given after other treatments did not work or stopped working.

Teniposide may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before I receive this drug?

You should not be treated with this medicine if you are allergic to teniposide or to polyoxyl 35 castor oil.

Tell your doctor if you have ever had:

  • Down Syndrome;
  • bone marrow suppression; or
  • liver or kidney disease.

Using teniposide may increase your risk of developing other cancers. Ask your doctor about this risk.

May cause birth defects. Do not use if you are pregnant. Use birth control while using teniposide and tell your doctor if you become pregnant.

This medication can decrease sperm count and may affect fertility in men (your ability to have children).

Do not breastfeed.

How is teniposide given?

Teniposide is injected into a vein by a healthcare provider.

This medicine is injected slowly over 30 to 60 minutes.

You may be given other medications to help prevent serious side effects or an allergic reaction.

Tell your caregivers if you feel any burning or pain when teniposide is injected.

You will be watched closely for at least 60 minutes to make sure you do not have an allergic reaction.

If this medicine gets in your eyes, mouth, nose, or on your skin, immediately wash the skin with soap and water or rinse your eyes with water.

Teniposide can increase your risk of bleeding or infection. You will need frequent medical tests. Your cancer treatments may be delayed based on the results.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your teniposide injection.

What happens if I overdose?

In a medical setting an overdose would be treated quickly.

What should I avoid while receiving teniposide?

Avoid activities that may increase your risk of bleeding or injury. Use extra care while shaving or brushing your teeth.

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

What are the possible side effects of teniposide?

Get emergency medical help if you have signs of an allergic reaction: hives, skin rash, warmth or tingling; fever, chills, feeling light-headed; wheezing, chest tightness, fast heartbeats, trouble breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during or shortly after the injection. Tell your care provider if you feel dizzy, nauseated, light-headed, feverish, chilled, itchy, anxious, or have chest tightness, trouble breathing, or warmth in your face.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • severe ongoing vomiting or diarrhea;
  • sores or white patches in or around your mouth, trouble swallowing or talking, dry mouth, bad breath, altered sense of taste;
  • pain, burning, irritation, or skin changes where the injection was given;
  • low blood cell counts --fever, chills, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath;
  • signs of too much acid in your blood --irregular heartbeats, feeling tired, loss of appetite, trouble thinking, feeling short of breath; or
  • symptoms of sepsis --confusion, severe drowsiness, fast heartbeats, rapid breathing, feeling very ill.

Common side effects may include:

  • nausea, vomiting, diarrhea;
  • mouth sores;
  • hair loss; or
  • infections, low blood cell counts.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect teniposide?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may affect teniposide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Where can I get more information?

Your doctor or pharmacist can provide more information about teniposide.

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