venlafaxine

What is the most important information I should know about venlafaxine?

Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

What is venlafaxine?

Venlafaxine is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant.

Venlafaxine is used in adults to treat major depressive disorder, anxiety, and panic disorder.

Venlafaxine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking venlafaxine?

Do not use venlafaxine within 7 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine. A dangerous drug interaction could occur.

Tell your doctor if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with venlafaxine could cause a serious condition called serotonin syndrome.

Tell your doctor if you have ever had:

• bipolar disorder (manic depression);
• liver disease;
• kidney disease;
• heart disease, high blood pressure, high cholesterol;
• diabetes;
• glaucoma;
• a thyroid disorder;
• a seizure;
• bleeding problems; or
• low blood levels of sodium.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Taking this medicine during pregnancy could harm the baby, but stopping the medicine may not be safe for you. Do not start or stop venlafaxine without asking your doctor.

How should I take venlafaxine?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

If you cannot swallow a capsule whole, open it and mix the medicine with applesauce. Swallow the mixture right away without chewing.

Do not stop using venlafaxine suddenly, or you could have unpleasant symptoms (such as agitation, confusion, tingling or electric shock feelings). Ask your doctor how to safely stop using this medicine.

Your symptoms may not improve for several weeks. You may have unpleasant symptoms if you stop using venlafaxine suddenly. Ask your doctor before stopping the medicine.

Your blood pressure will need to be checked often.

This medicine may cause false results on a drug-screening urine test. Tell the laboratory staff that you use venlafaxine.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

What should I avoid while taking venlafaxine?

Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen, naproxen, Advil, Aleve, Motrin, and others. Using an NSAID with venlafaxine may cause you to bruise or bleed easily.

What are the possible side effects of venlafaxine?

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

• blurred vision, eye pain or redness, seeing halos around lights;
• cough, chest tightness, trouble breathing;
• a seizure (convulsions);
• unusual bleeding --nosebleeds, bleeding gums, abnormal vaginal bleeding, any bleeding that will not stop;
• low blood sodium --headache, confusion, problems with thinking or memory, weakness, feeling unsteady; or
• severe nervous system reaction --very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Common side effects may include:

• headache, dizziness, drowsiness, tiredness;
• feeling anxious, nervous, or jittery;
• sleep problems, unusual dreams;
• tremors;
• fast heartbeats;
• blurred vision;
• nausea, vomiting, diarrhea, constipation;
• changes in weight or appetite;
• dry mouth, yawning;
• increased sweating; or
• sexual problems.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect venlafaxine?

Tell your doctor about all your current medicines. Many drugs can affect venlafaxine, especially:

• any other antidepressant;
• cimetidine;
• tramadol;
• St. John's wort, tryptophan (sometimes called L-tryptophan);
• diet pills, weight loss medicine (such as phentermine);
• a blood thinner --warfarin, Coumadin, Jantoven;
• medicine to treat mood disorders, thought disorders, or mental illness --buspirone, lithium, and many others; or
• migraine headache medicine --sumatriptan, zolmitriptan, and others.

This list is not complete and many other drugs may affect venlafaxine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about venlafaxine.