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Home Knowledge Center Wellness Library Ankylosing spondylitis

Ankylosing spondylitis

Ankylosing spondylitis is a form of joint inflammation (arthritis) that is long-lasting (chronic) and most often affects the spine. Ankylosing spondylitis commonly causes pain and stiffness, with limited motion in the low back, middle back, neck, hips, chest wall, and heels.

Ankylosing spondylitis is a specific disease within a family of diseases called spondyloarthropathies. The cause of the disease is not known. In severe cases the affected joints in the spine fuse together. This causes severe stiffness in the back. Other joints can be stiff and painful, including those in the shoulders, wrists, hands, knees, ankles, and feet. Complications of ankylosing spondylitis may include inflammation of the colored part of the eye (iris), called iritis, or difficulty breathing due to curving of the upper body and stiffening of the chest wall. Inflammation from the condition may also affect the heart valves. In rare cases of severe disease, the artery called the aorta, the lungs, the kidneys, and the digestive tract can also be affected.

Ankylosing spondylitis usually affects people younger than about 35. It can run in families. And it is more common in men than in women.

Although there is no cure, treatment can usually control symptoms and prevent the condition from getting worse. Most people are able to continue to work and do normal daily activities.

Current as of: July 24, 2025

Author: Ignite Healthwise, LLC Staff

Clinical Review Board
All Ignite Healthwise, LLC education is reviewed by a team that includes physicians, nurses, advanced practitioners, registered dieticians, and other healthcare professionals.

This information does not replace the advice of a doctor. Ignite Healthwise, LLC, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

To learn more about Ignite Healthwise, LLC, visit webmdignite.com.

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