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Home Knowledge Center Wellness Library Chickenpox and Smallpox Rash Comparison

Chickenpox and Smallpox Rash Comparison
Chickenpox and smallpox rashes

Source: The U.S. Centers for Disease Control and Prevention (CDC).

Differences between chickenpox and smallpox
​

Chickenpox

Smallpox

How initial symptoms differ

0 to 2 days of mild illness pass before the rash develops.

2 to 3 days of severe illness pass before the rash develops.

Lesions first appear on the face or trunk.

Lesions first appear in the throat or mouth, then on the face, or on the upper arms.

How the rash lesions differ

Lesions develop in successive fashion. While some are new, others are crusting over (in "crops").

Lesions develop at the same time, and they look alike on any one section of the body, such as the abdomen, arms, or face.

Lesions change rapidly, crusting over within 24 hours.

Lesions change slowly, scabbing over after 9 to 15 days.

Lesions sit on the skin surface and look like small blisters.

Lesions become firm, dome-shaped, and deep in the skin.

Rash rarely develops on palms and soles.

Rash commonly develops on palms of the hands and soles of the feet.

Lesions are most concentrated on the torso, with fewest on the hands and feet. Lesions can affect the face and scalp, but rarely affect the entire body equally.

Lesions are most concentrated on the face, hands, and feet.

Current as of: April 30, 2024

Author: Ignite Healthwise, LLC Staff

Clinical Review Board
All Ignite Healthwise, LLC education is reviewed by a team that includes physicians, nurses, advanced practitioners, registered dieticians, and other healthcare professionals.

This information does not replace the advice of a doctor. Ignite Healthwise, LLC, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

To learn more about Ignite Healthwise, LLC, visit webmdignite.com.

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