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Home Knowledge Center Wellness Library Integrated test during pregnancy (birth defects testing)

Integrated test during pregnancy (birth defects testing)

The integrated test is a screening test done during pregnancy to find out the chance that a baby has certain birth defects, such as Down syndrome. The test is done in two stages at two different times during the pregnancy. You will get the results after the tests in the second trimester are done.

  • The first stage can be done around 10 to 13 weeks of pregnancy. The tests done for this stage are:
    • An ultrasound. The ultrasound can show the age of the baby and measure the thickness of the skin at the back of the baby's neck (nuchal translucency, or NT).
    • A blood test to measure the level of a substance in the blood called pregnancy-associated plasma protein A (PAPP-A).
  • The second stage can usually be done between weeks 15 and 22. The tests done for this stage are all blood tests and include:
    • Alpha-fetoprotein (AFP).
    • Beta-human chorionic gonadotropin (hCG).
    • Unconjugated estriol (a form of estrogen).
    • Inhibin A.

The results of all these tests are reviewed to see if levels are higher or lower than expected, and the results are reported after the second stage.

Current as of: July 15, 2025

Author: Ignite Healthwise, LLC Staff

Clinical Review Board
All Ignite Healthwise, LLC education is reviewed by a team that includes physicians, nurses, advanced practitioners, registered dieticians, and other healthcare professionals.

This information does not replace the advice of a doctor. Ignite Healthwise, LLC, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

To learn more about Ignite Healthwise, LLC, visit webmdignite.com.

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