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Home Knowledge Center Wellness Library Antibody Tests for Lupus

Antibody Tests for Lupus

Overview

Antibody tests are a set of blood tests that check for specific antibodies to help clarify the diagnosis of lupus. They include:

  • Anti-dsDNA (antibodies to DNA).
  • Antinuclear antibody (ANA)
  • Anti-RNP.
  • Anti-Smith (Sm).
  • Anti-SS-A (also called Ro).
  • Anti-SS-B (also called La).

These antibody tests are often positive in lupus and can provide support for a diagnosis if the clinical criteria are unclear or if the ANA test is negative but lupus is strongly suspected.

  • Anti-SS-A (Ro) and anti-SS-B (La) antibodies are not specific for lupus and are found commonly in Sjögren's syndrome. But these tests are useful in helping women with lupus who are considering pregnancy. If a woman who has these antibodies becomes pregnant, she may need more careful monitoring of the fetus, since these antibodies are associated with a higher risk of the baby being born with neonatal lupus syndrome or a heart defect called congenital heart block.
  • High titers of anti-dsDNA are usually seen only in people who have lupus.
  • A positive anti-Sm test is a specific marker for lupus.

Anti-dsDNA tests can be repeated at intervals to monitor how the disease is progressing.

This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

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