Skip to main navigation Skip to main content Skip to footer For Medicare For Providers For Brokers For Employers Español For Individuals & Families: For Individuals & Families Medical Dental Other Supplemental Explore coverage through work How to Buy Health Insurance Types of Dental Insurance Open Enrollment vs. Special Enrollment See all topics Shop for Medicare plans Member Guide Find a Doctor Log in to myCigna
Home Knowledge Center Wellness Library Bone Marrow Aspiration and Biopsy

Bone Marrow Aspiration and Biopsy

Test Overview

Bone marrow aspiration is a procedure that takes out a small amount of bone marrow fluid through a needle. Bone marrow biopsy uses a needle to take out a small amount of bone with the marrow inside it. These samples are then checked under a microscope. The hip bone is the most often used area for these procedures.

Aspiration and biopsy are often done to find a blood problem or an infection. They also may be used to find out if a cancer has spread to the bone marrow. The procedure can also be done to collect bone marrow for medical procedures, such as stem cell transplant or chromosomal analysis.

You may get medicine to help you relax before the procedure. The doctor will inject numbing medicine in the skin over your bone. He or she will put a needle through your skin and into your bone to reach the bone marrow. You may feel pressure or some dull pain during the procedure. After the doctor takes the sample, he or she will remove the needle. The doctor may need to take more than one sample. This can come from the same spot or from a different area on your body. When the procedure is done, the doctor or a nurse will put pressure on the area to stop any bleeding.

Why It Is Done

Why It Is Done

A bone marrow aspiration, biopsy, or both are done to:

  • Look for the cause of problems with red blood cells, white blood cells, or platelets in people who have conditions such as thrombocytopenia, anemia, or an abnormal white blood cell count.
  • Find blood disorders, such as leukemia, certain anemias, or problems that affect the bone marrow, such as multiple myeloma or polycythemia vera.
  • Check to see if a known cancer, such as Hodgkin lymphoma or non-Hodgkin lymphoma, has spread to the bone marrow. This is part of what is called staging. It is done to find out if the cancer has spread and how much it has spread. This helps plan cancer treatment.
  • Find infections or tumors that may start in or spread to the bone marrow. If you have an infection, a culture and sensitivity test of the bone marrow sample may be used to find out which antibiotics will work best to treat the infection.
  • Find the best treatment for a bone marrow problem. After treatment has been started, a bone marrow aspiration and biopsy may be done to see if the leukemia cells are gone. This means the treatment is working.
  • Collect a sample of bone marrow for medical procedures, such as stem cell transplant or chromosomal analysis.
How To Prepare

How To Prepare

  • Tell your doctor ALL the medicines, vitamins, supplements, and herbal remedies you take. Some may increase the risk of problems during your procedure. Your doctor will tell you if you should stop taking any of them before the procedure and how soon to do it.
  • If you take aspirin or some other blood thinner, ask your doctor if you should stop taking it before your procedure. Make sure that you understand exactly what your doctor wants you to do. These medicines increase the risk of bleeding.
  • Be sure you have someone to take you home. Anesthesia and pain medicine will make it unsafe for you to drive or get home on your own.
How It Is Done

How It Is Done

This biopsy may be done in your doctor's office or in a hospital.

You may need to take off all or most of your clothes, depending on what part of the body the biopsy or aspiration is taken from. If needed, you will be given a gown to use during the biopsy.

During the test

Blood samples from a vein in your arm may be taken before the bone marrow biopsy. In rare cases, you may be given a blood product (clotting factor or platelets) into a vein (IV) in your arm to prevent bleeding after the biopsy.

Adults usually have a sample of bone marrow fluid taken from the back of the pelvic bone. In rare cases a fluid sample is removed from the front of the pelvic bone. Babies and young children may have the sample taken from the front of the lower leg bone, just below the knee. A bone marrow biopsy is only taken from the pelvic bone.

You may be given a sedative to help you relax. You will lie either on your side or facedown on your belly for the biopsy. It is important that you lie still in that position during the biopsy.

The skin over the aspiration site will be cleaned with a special liquid. A medicine (local anesthetic) will be used to numb the area. Then the aspiration needle will be put through your skin and into your bone to reach the bone marrow. You need to lie very still while the sample is taken. The needle is then taken out. More than one sample may be needed. They may be taken from more than one place on your body, such as from both sides of the pelvic bone.

After the samples have been taken, pressure is put on the site to stop any bleeding. A bandage is put on the area.

How It Feels

How It Feels

This procedure may be painful, but only for a few seconds. You may feel a sharp sting and burn when the anesthetic numbs your skin over the aspiration or biopsy site. You may hear a crunching sound and feel pressure and some pain when the needle enters the bone. During an aspiration, you may feel a quick, shooting pain down your leg as the sample is taken.

Risks

Risks

Serious problems from a bone marrow aspiration or biopsy aren't common. Problems may include:

  • Bleeding from the biopsy site. People with bleeding problems have a higher chance for this. If you have bleeding problems, pressure will be put on the biopsy site for at least 10 minutes after the biopsy. In rare cases, you may be given a blood product (clotting factor or platelets) in a vein in your arm before the biopsy to prevent bleeding after the biopsy.
  • Infection of skin or the bone (osteomyelitis) at the biopsy site.
  • Injury to your heart, a lung, or a major blood vessel if the sample is taken from the breastbone (sternum). This complication is very rare. Samples are not often taken from the breastbone, so most people don't have to worry about this risk.
Results

Results

Biopsy results are usually ready in 1 to 7 days. But it may take several weeks to get the results if genetic tests are done on the sample. The bone is put into a solution that breaks down its calcium before it is stained. The bone marrow sample is often treated with special dyes (stains) to see any changes in the blood cells more clearly.

Bone marrow biopsy and aspiration

Normal:

The marrow has normal amounts of fat, connective tissue, and iron. Normal numbers of both mature and immature (growing) bone marrow cells are present.

No signs of infection are seen.

No cancer cells, such as leukemia, lymphoma, or multiple myeloma, are seen.

No cancer cells have spread from other cancer sites, such as breast cancer.

Abnormal:

The cells in the bone marrow do not look normal.

There are too many or too few bone marrow cells. The bone tissue does not look normal.

Too much iron or too little iron (iron deficiency anemia) is seen in the bone marrow.

Signs of infection are seen in the bone marrow.

Cancer cells, such as leukemia, lymphoma, or multiple myeloma, are seen.

The bone marrow has been replaced by scar tissue.

Normal bone marrow in one site does not mean that all sites in the body are normal.

This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

© 1995-2022 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

Related Links

Medical Tests: Questions to Ask the Doctor

<cipublic-spinner variant="large"><span>Loading…</span></cipublic-spinner>

Page Footer

I want to...

Get an ID card File a claim View my claims and EOBs Check coverage under my plan See prescription drug list Find an in-network doctor, dentist, or facility Find a form Find 1095-B tax form information View the Cigna Glossary Contact Cigna

Audiences

Individuals and Families Medicare Employers Brokers Providers

Secure Member Sites

myCigna member portal Health Care Provider portal Cigna for Employers Client Resource Portal Cigna for Brokers

Cigna Company Information

About Cigna Company Profile Careers Newsroom Investors Suppliers Third Party Administrators International Evernorth

 Cigna. All rights reserved.

Privacy Legal Product Disclosures Cigna Company Names Customer Rights Accessibility Non-Discrimination Notice [PDF] Language Assistance [PDF] Report Fraud Sitemap

Disclaimer

Individual and family medical and dental insurance plans are insured by Cigna Health and Life Insurance Company (CHLIC), Cigna HealthCare of Arizona, Inc., Cigna HealthCare of Illinois, Inc., and Cigna HealthCare of North Carolina, Inc. Group health insurance and health benefit plans are insured or administered by CHLIC, Connecticut General Life Insurance Company (CGLIC), or their affiliates (see a listing of the legal entities  that insure or administer group HMO, dental HMO, and other products or services in your state). Accidental Injury, Critical Illness, and Hospital Care plans or insurance policies are distributed exclusively by or through operating subsidiaries of Cigna Corporation, are administered by Cigna Health and Life Insurance Company, and are insured by either (i) Cigna Health and Life Insurance Company (Bloomfield, CT); (ii) Life Insurance Company of North America (“LINA”) (Philadelphia, PA); or (iii) New York Life Group Insurance Company of NY (“NYLGICNY”) (New York, NY), formerly known as Cigna Life Insurance Company of New York. The Cigna name, logo, and other Cigna marks are owned by Cigna Intellectual Property, Inc. LINA and NYLGICNY are not affiliates of Cigna.

All insurance policies and group benefit plans contain exclusions and limitations. For availability, costs and complete details of coverage, contact a licensed agent or Cigna sales representative. This website is not intended for residents of New Mexico.

Selecting these links will take you away from Cigna.com to another website, which may be a non-Cigna website. Cigna may not control the content or links of non-Cigna websites. Details