Skip to main navigation Skip to main content Skip to footer For Medicare For Providers For Brokers For Employers Español For Individuals & Families: For Individuals & Families Medical Dental Other Supplemental Explore coverage through work How to Buy Health Insurance Types of Dental Insurance Open Enrollment vs. Special Enrollment See all topics Shop for Medicare plans Member Guide Find a Doctor Log in to myCigna
Home Knowledge Center Wellness Library Sickle Cell Test

Sickle Cell Test

Test Overview

A sickle cell test is a blood test done to check for sickle cell trait or sickle cell disease. Sickle cell disease is an inherited blood disease that causes red blood cells to be deformed (sickle-shaped). The red blood cells deform because they contain an abnormal type of hemoglobin, called hemoglobin S, instead of the normal hemoglobin, called hemoglobin A.

Sickled blood cells are destroyed by the body faster than normal blood cells. This causes anemia. Also, sickled cells can get trapped in blood vessels and reduce or block blood flow. This can damage organs, muscles, and bones and may lead to life-threatening conditions.

The best way to check for sickle cell trait or sickle cell disease is to look at the blood using a method called high-performance liquid chromatography (HPLC). This test identifies which type of hemoglobin is present. To confirm the results of HPLC, a genetic test may be done.

A person inherits two sets of genes (one set from each parent). As a result, a person may have:

  • Two sets of genes that make normal hemoglobin (hemoglobin A). These people have normal red blood cells unless they have some other blood disease.
  • One set of genes that makes normal hemoglobin (hemoglobin A) and one set that makes hemoglobin S. These people carry the sickle cell trait (and are called "carriers"), but they do not have sickle cell disease. Sickle cell trait is usually a harmless condition.
  • Two sets of genes that make hemoglobin S. These people have sickle cell disease. Both parents either carry the sickle cell trait or have the disease. Sickled red blood cells often cause recurring health problems called sickle cell crises.
  • One set of genes that makes hemoglobin S and one set that makes some other abnormal type of hemoglobin. Depending on the other type of abnormal hemoglobin, these people may have mild or severe sickle cell disorder.

The United States Preventive Services Task Force recommends that all newborns be tested for sickle cell disease. footnote 1

Why It Is Done

Why It Is Done

A sickle cell test is done to help diagnose sickle cell disease.

A sickle cell test is also done to screen for sickle cell trait or sickle cell disease. This test may be done for newborns and for people at high risk. Detecting sickle cell trait is important for couples who want to have children and who may be carriers of sickle cell trait.

How To Prepare

How To Prepare

Be sure to tell your doctor if you have had a blood transfusion in the past 4 months because it can interfere with the test results.

How It Is Done

How It Is Done

Blood sample from a vein

A health professional uses a needle to take a blood sample, usually from the arm.

Blood sample from a heel stick

A heel stick is used to get a blood sample from a baby. The baby's heel is poked, and several drops of blood are collected.

How It Feels

How It Feels

Blood sample from a vein

When a blood sample is taken, you may feel nothing at all from the needle. Or you might feel a quick sting or pinch.

Blood sample from a heel stick

A brief pain, like a sting or a pinch, is usually felt when the lancet punctures the skin. Your baby may feel a little discomfort with the skin puncture.

Risks

Risks

Blood sample from a vein

There is very little chance of having a problem from this test. When a blood sample is taken, a small bruise may form at the site.

Blood sample from a heel stick

There is very little risk of a problem from a heel stick. Your baby may get a small bruise at the puncture site.

Results

Results

Sickle cell test footnote 2

Normal:

Normal hemoglobin is present.

Abnormal:

Abnormal hemoglobin is present.

  • In sickle cell trait, more than half of the hemoglobin is normal (hemoglobin A) and less than half is abnormal (hemoglobin S).
  • In sickle cell disease, almost all hemoglobin is hemoglobin S with some hemoglobin called hemoglobin F.

In babies, a sickle cell blood test may be repeated at 6 months old, or a genetic information (DNA) test may be done.

References

References

Citations

  1. U.S. Preventive Services Task Force (2007). Screening for sickle cell disease in newborns. Available online: http://www.ahrq.gov/clinic/uspstf/uspshemo.htm.
  2. Fischbach FT, Dunning MB III, eds. (2009). Manual of Laboratory and Diagnostic Tests, 8th ed. Philadelphia: Lippincott Williams and Wilkins.

This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

© 1995-2022 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

Related Links

Genetic Testing and Screening Sickle Cell Disorders Medical Tests: Questions to Ask the Doctor

<cipublic-spinner variant="large"><span>Loading…</span></cipublic-spinner>

Page Footer

I want to...

Get an ID card File a claim View my claims and EOBs Check coverage under my plan See prescription drug list Find an in-network doctor, dentist, or facility Find a form Find 1095-B tax form information View the Cigna Glossary Contact Cigna

Audiences

Individuals and Families Medicare Employers Brokers Providers

Secure Member Sites

myCigna member portal Health Care Provider portal Cigna for Employers Client Resource Portal Cigna for Brokers

Cigna Company Information

About Cigna Company Profile Careers Newsroom Investors Suppliers Third Party Administrators International Evernorth

 Cigna. All rights reserved.

Privacy Legal Product Disclosures Cigna Company Names Customer Rights Accessibility Non-Discrimination Notice [PDF] Language Assistance [PDF] Report Fraud Sitemap

Disclaimer

Individual and family medical and dental insurance plans are insured by Cigna Health and Life Insurance Company (CHLIC), Cigna HealthCare of Arizona, Inc., Cigna HealthCare of Illinois, Inc., and Cigna HealthCare of North Carolina, Inc. Group health insurance and health benefit plans are insured or administered by CHLIC, Connecticut General Life Insurance Company (CGLIC), or their affiliates (see a listing of the legal entities  that insure or administer group HMO, dental HMO, and other products or services in your state). Accidental Injury, Critical Illness, and Hospital Care plans or insurance policies are distributed exclusively by or through operating subsidiaries of Cigna Corporation, are administered by Cigna Health and Life Insurance Company, and are insured by either (i) Cigna Health and Life Insurance Company (Bloomfield, CT); (ii) Life Insurance Company of North America (“LINA”) (Philadelphia, PA); or (iii) New York Life Group Insurance Company of NY (“NYLGICNY”) (New York, NY), formerly known as Cigna Life Insurance Company of New York. The Cigna name, logo, and other Cigna marks are owned by Cigna Intellectual Property, Inc. LINA and NYLGICNY are not affiliates of Cigna.

All insurance policies and group benefit plans contain exclusions and limitations. For availability, costs and complete details of coverage, contact a licensed agent or Cigna sales representative. This website is not intended for residents of New Mexico.

Selecting these links will take you away from Cigna.com to another website, which may be a non-Cigna website. Cigna may not control the content or links of non-Cigna websites. Details