Deep Brain Stimulation (DBS) Surgery

What To Expect

You will stay in the hospital for several days after the procedure while your doctor checks the effect of DBS.

Why It Is Done

DBS may be used to relieve symptoms of Parkinson's disease, especially tremor, when they can't be controlled with medicine. It's the surgical treatment of choice for Parkinson's disease. That's because it works better, is safer, and is less harmful to brain tissue than other surgical methods.

DBS of the thalamus is done to treat both disabling tremor caused by Parkinson's disease and essential tremor.

Procedures that stimulate parts of the brain called the subthalamic nucleus and the globus pallidus are done to help control a wider range of symptoms (along with tremor). They are used more often than stimulation of the thalamus. Symptoms that are most often helped (besides tremor) include problems with changes between "on" and "off" time and dyskinesia. "On" time is when medicine taken for Parkinson's is helping your symptoms. Symptoms that are less likely to get better include problems with walking, balance, and speech. In some cases, DBS can make these problems worse.

DBS may also be used to treat severe tremor related to multiple sclerosis (MS). It usually is a last resort after all other options have been tried without success to treat MS tremor. Only people with severe tremor are candidates.

How Well It Works

Compared to only taking medicine for Parkinson's disease, having DBS of either the subthalamic nucleus (STN) or globus pallidus (GPi) along with taking medicine gave people almost 5 more hours of "on" time on average each day.^{footnote 1} "On" time is when medicine taken for Parkinson's is helping your symptoms.

DBS of the thalamus only works to reduce tremor. It does not affect other motor symptoms.^{footnote 2}

Two studies compared DBS of the STN to DBS of the GPi. The studies showed similar reductions of motor symptoms of Parkinson's disease after 1 and 2 years.^{footnote 3, footnote 4}

• The group that had DBS of the STN was able to take less medicine for Parkinson's disease after 2 or 3 years compared to the group that had DBS of the GPi.
• Quality of life was similar between the two groups.

Risks

Risks of DBS include:

• Infection or skin irritation caused by the device in the chest (stimulator) or by the wires or electrodes.
• Bleeding in the brain during the surgery, resulting in a stroke.
• Numbness, tingling, twitching, or other abnormal sensations when the device is turned on. (These usually don't last long and can be stopped by adjusting the programming of the deep brain stimulation device.)
• Problems with the device, such as:
  • A break in the wire leading from the electrode to the stimulator.
  • Movement of the wires or the device under the skin.
  • Need for a new battery for the device. A battery typically will last about 5 years.
  • Failure or malfunction of the stimulator or the electrodes.
• Psychological problems, such as apathy and depression.
• Problems with thinking, memory, speech, or swallowing.
• Trouble with walking or balance and an increased risk of falling.
• Seizures.