Skip to main navigation Skip to main content Skip to footer For Medicare For Providers For Brokers For Employers Español For Individuals & Families: For Individuals & Families Medical Dental Other Supplemental Explore coverage through work How to Buy Health Insurance Types of Dental Insurance Open Enrollment vs. Special Enrollment See all topics Shop for Medicare plans Member Guide Find a Doctor Log in to myCigna
Home Knowledge Center Wellness Library Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Condition Basics

What is myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)?

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease that causes you to feel so ill that you can't do your normal activities. Sleeping problems occur along with extreme fatigue that doesn't get better with rest. Any kind of activity often makes your symptoms worse. You may have other symptoms like problems with thinking.

What causes it?

Doctors don't know what causes ME/CFS. It seems to follow after a flu-like illness. High stress may also lead to ME/CFS for some people. And changes in a person's immune system may also play a role. It's likely that a number of factors or triggers come together to cause ME/CFS.

What are the symptoms?

Symptoms can vary with ME/CFS. If you have ME/CFS:

  • You feel exhausted all or much of the time. And it doesn't get better with rest.
  • Your symptoms often flare up after a mental or physical activity that used to be no problem for you. There may be a day or two delay before it starts. And it may take days, weeks, or more to feel better.
  • You have problems sleeping. Or you may wake up feeling tired or not rested.
  • It may be harder for you to think clearly, concentrate, and remember things.
  • You may feel dizzy, weak, or in more pain when you have been standing or sitting upright for a long time.
  • You may also have headaches, muscle and joint pain, a sore throat, and tender glands in your neck or armpits.

Depression is common with ME/CFS, and it can make your other symptoms worse.

How is it diagnosed?

To be diagnosed with ME/CFS, you must have all of these symptoms:footnote 1

  • Major decrease in your ability to do the things you did before you got sick—including work, school, social, or personal activities—that has continued for more than 6 months.
  • Worsening of symptoms after being mentally or physically active (post-exertional malaise).
  • Sleep problems, including not feeling rested after sleeping (unrefreshed sleep).
  • Extreme fatigue that is:
    • New or has not been a life-long problem.
    • Not caused by being active for a long period of time.
    • Not much better after resting.

You must also have one or more of these symptoms:

  • Problems with concentration, short-term memory, or using the correct word (cognitive impairment).
  • Feeling dizzy or faint while standing or sitting upright that gets better when you lie down (orthostatic intolerance).

Doctors may also use a variety of tests to confirm a diagnosis or to rule out other conditions.

How is ME/CFS treated?

There isn't a cure yet for ME/CFS. So the keys to living with ME/CFS are learning how to pace your activities and treating your symptoms.

There are some things you can do to treat the most common symptoms.

  • For symptoms that are worse after activity (also called post-exertional malaise), learn how to manage your activity. Think about how much energy you have on a given day and try not to "spend" more than you have.
  • If you feel dizzy or weak while sitting or standing, you can try wearing pressure stockings or putting your feet up. Or your doctor may recommend eating more salt or taking certain medicines.
  • Sleep problems may improve with better sleep habits. You can also ask your doctor how medicines can help.
  • Pain can be treated with over-the-counter medicines. Some prescription medicines may also help.
  • If you're feeling depressed, talk to your doctor.
Health Tools

Health Tools

Health Tools help you make wise health decisions or take action to improve your health.

Actionsets are designed to help people take an active role in managing a health condition.
Cause

Cause

Doctors don't know what causes ME/CFS. It seems to follow after a flu-like illness like Epstein-Barr Virus (EBV). But EBV doesn't cause all cases of ME/CFS. Other infections like parvovirus B19 and Ross River virus may also be linked to ME/CFS.

High stress may also lead to ME/CFS for some people. This could be a period of high physical or emotional stress or a major life event.

Changes in a person's immune system may also play a role.

It's likely that a number of factors come together to cause ME/CFS.

Symptoms

Symptoms

ME/CFS symptoms usually start suddenly. But for some people, they develop slowly over weeks or months. Symptoms can change in a day, and from day to day. And how severe the symptoms are can differ from person to person.

Symptoms can vary with ME/CFS. But there is a core set of symptoms that affect nearly everyone with ME/CFS.

Core symptoms

The core symptoms are:

Extreme physical fatigue, mental fatigue, or both.

Fatigue can be constant, or it can come and go. It's not relieved by rest. This fatigue also is so severe that it interferes with your work, play, and social activities.

Worsening of symptoms after activity (post-exertional malaise).

You may feel ill or weak or that your ME/CFS symptoms are worse after physical or mental activity. Even daily activities like showering, cooking, and reading can trigger symptoms. Often there is a delay of 24 hours before it starts. It can take days, weeks, or more to feel better.

Sleep problems.

You may have trouble sleeping. Or you may wake up feeling tired or not rested.

Problems with thinking (cognitive impairment).
You may have problems concentrating, remembering, or thinking of the right word.
Feeling dizzy or faint while in an upright position (orthostatic intolerance).
You may feel dizzy, weak, exhausted, confused, or in more pain when you have been standing or sitting upright for a long time. These symptoms usually improve or go away when you lie down.

Other symptoms

ME/CFS may also cause other symptoms. These may be just as common as the core symptoms. Different people with ME/CFS have different combinations of:

  • Pain, which can be widespread or in one place. ME/CFS pain can be in one area, then move to another. You may have:
    • Muscle pain.
    • Joint pain.
    • A headache.
  • Tender glands in your neck or armpits.
  • Sensitivity to light, noise, chemicals, and certain foods.
  • Flu-like symptoms like fever and sore throat.
  • Urinating often.
  • Digestive issues like bloating, abdominal pain, nausea, diarrhea, or constipation.
  • Low body temperature, cold hands and feet, sweating, or trouble with heat or cold.
  • Feeling worse after any kind of physical or emotional stress.
  • Weight change or appetite change.

It's common for people with a chronic condition like ME/CFS to feel depressed. Some may grieve the loss of the active life they once had. If you feel depressed, talk with your doctor. Treatment for depression may prevent ME/CFS symptoms from getting worse.

What Happens

What Happens

ME/CFS may come upon you gradually or all of a sudden. It is hard to say what is normal with ME/CFS. That's because the diagnosis often is not clear for some time.

In general, most people with ME/CFS:

  • Feel that the illness doesn't improve over time.
  • Report that symptoms are always present. But from day to day, symptoms may be better or worse.

But some people with ME/CFS may:

  • Feel that the illness gets worse over time.
  • Notice that their symptoms go away completely and then return.
  • Notice that their symptoms get better with treatment, but they don't return to feeling as well as they did before the illness.

Most people with ME/CFS find that their symptoms greatly reduce their ability to do the things they want and need to do. But ME/CFS is different for everyone. Symptoms are worse for some people than for others.

When to Call a Doctor

When to Call a Doctor

It's important to talk to your doctor about any symptoms you may have.

Call your doctor if you have:

  • Severe fatigue that lasts longer than 2 weeks, causes you to limit your usual activities, and does not improve with rest.
  • Sleep problems that last for more than 1 to 2 months. These problems may include being unable to fall asleep or stay asleep, tossing and turning, and waking up feeling tired or not rested.
  • Swelling in the glands in your neck or armpits (without other signs of infection) that lasts for at least 2 weeks.
  • Severe fatigue along with frequent urination (especially at night), extreme thirst, weight loss, or blurred vision. Fatigue that occurs with some or all of these may be a symptom of undiagnosed diabetes.
  • Severe headache that does not improve with home treatments.

Watchful waiting

Watchful waiting is a wait-and-see approach. A month or two of paying close attention to your sleep habits, trying to control stress, and eating a balanced diet will take care of most cases of fatigue not caused by ME/CFS or another medical problem. But if your fatigue has not improved after 1 to 2 months of self-care, or if fatigue won't go away and limits your usual activities, call your doctor.

If you have been diagnosed with ME/CFS, pay attention to any new or worsening symptoms and report them to your doctor. Although ME/CFS can cause a variety of symptoms, new symptoms could be caused by another illness or medical condition that may need to be evaluated and treated.

Who to see

While there are doctors who specialize in the treatment of ME/CFS, it is always wise to start with your family doctor and learn as much as you can about the illness.

Depending on your symptoms, your family doctor may refer you to a specialist like a physiatrist, rheumatologist, neurologist, pain management specialist, or cardiologist.

It's common to also have depression or anxiety along with a chronic condition like ME/CFS. So you may also be referred to a psychologist, or psychiatrist for treatment.

Exams and Tests

Exams and Tests

Doctors use a specific list of symptoms to diagnose ME/CFS. Sometimes they may have you track your symptoms, activity, and rest in a diary. Since symptoms of ME/CFS can be similar to other conditions, doctors may do additional tests to confirm a diagnosis of ME/CFS. Or they may use a variety of tests to rule out other conditions.

Criteria for diagnosing ME/CFS

To be diagnosed with ME/CFS, you must have all of these symptoms:footnote 1

  • Major decrease in your ability to do the things you did before you got sick—including work, school, social, or personal activities—that has continued for more than 6 months.
  • Worsening of symptoms after being mentally or physically active (post-exertional malaise).
  • Sleep problems, including not feeling rested after sleeping (unrefreshed sleep).
  • Extreme fatigue that is:
    • New or has not been a life-long problem.
    • Not caused by being active for a long period of time.
    • Not much better after resting.

You must also have one or more of these symptoms:

  • Problems with concentration, short-term memory, or using the correct word (cognitive impairment).
  • Feeling dizzy or faint while standing or sitting upright that gets better when you lie down (orthostatic intolerance).

Tests to confirm a diagnosis of ME/CFS

Other conditions can cause symptoms similar to ME/CFS, so your doctor may do more tests to confirm the diagnosis. These may include:

Orthostatic testing.
Tests may be done to see if you have symptoms after being upright for long periods of time.
Neuropsychological testing.
This may be done to see if you are having problems with your ability to think, concentrate, or remember.
Cardiopulmonary exercise test (CPET).
This may be done to see if you recover after physical activity. Often the test is done and repeated about 24 hours later.

Tests to rule out other conditions

Other tests, such as blood or urine tests, may be done to rule out other conditions. And based on your symptoms, the doctor may do additional tests to look for signs of a chronic infection, autoimmune disease, or low levels of hormones.

Learn more

Treatment Overview

Treatment Overview

There isn't a cure yet for ME/CFS. So the keys to living with ME/CFS are learning how to pace your activities and treating your symptoms. Find a primary doctor who understands ME/CFS, knows how to treat it, and helps you feel supported.

A good relationship with your doctor is important. That's because the two of you will need to work together to find a mix of medicines and behavior changes that will help you get better. Some trial and error may be needed. That's because no single combination of treatments works for everyone.

Treat the worst symptom first

Start by listing your worst symptoms—the ones that make it hardest to get through the day. With your doctor, focus first on treating those symptoms. Decide whether a specialist might be helpful for any of them.

The most common ME/CFS symptoms can also be the most treatable.

Symptoms worse after activity (post-exertional malaise).

Learning how to manage your activity can help you be as active as possible without causing your symptoms to get worse. This includes:

  • Estimating how much energy you have on a given day. This is sometimes called your "energy envelope." You spend only that much energy, and not more.
  • Estimating how much energy an activity takes and how long you can do that activity. You stop when you reach that time, and then take a break.
  • Not pushing yourself to get more done on days you feel well.
  • Adapting activities to make them easier. One example is sitting down while doing the dishes.
Sleep.

Good sleep habits can help improve the quality of your sleep. If you also try medicine for sleep, it's best to start on a low dose. Certain antidepressants help with sleep, mood, and chronic pain, so your doctor may suggest trying one.

Feeling dizzy or weak while sitting or standing (orthostatic intolerance).

Your doctor may have you wear pressure stockings, put your legs up while sitting, or increase your salt intake. Your doctor may also suggest medicines like fludrocortisone or midodrine.

Pain.

Different kinds of pain can be treated in different ways. If one treatment doesn't work, you and your doctor can try another until you find what works best for you.

  • It's important to control focused pain, such as arthritis or migraine. This kind of pain can make ME/CFS body pain worse. First try an over-the-counter pain reliever, like acetaminophen (such as Tylenol), ibuprofen (such as Advil or Motrin), or naproxen (such as Aleve). Be safe with medicines. Read and follow all instructions on the label.
  • There are different types of prescription medicines that help with pain, such as antidepressants or anticonvulsants for chronic pain.
  • Other treatments that can help with ME/CFS pain include acupuncture or massage. Yoga may also help. Look for a gentle form of yoga. It may be best to start off with short sessions at home.

Cope with depression, anxiety, and distress

When you have ME/CFS, you may not be able to do the things you would like to do. This may lead to feelings of frustration and anxiety. It can also lead to depression. Depression is not the same thing as ME/CFS. But it can make your ME/CFS symptoms worse.

  • Work with your doctor to watch for signs of depression.
  • If your doctor suggests an antidepressant, ask if there is one that can help control your pain and help you sleep, as well as improve your mood.
  • For support and help with mood problems, you can also work with a professional counselor who understands ME/CFS.

An ME/CFS support group can be a good source of information and tips for managing your illness. It also gives you a chance to share your frustrations and problems with others who have ME/CFS.

Get the care you need

Visit your doctor every few months to help track your symptoms and check for any need to change your treatment.

Get specialized care if you need it. For example:

  • A rehabilitation specialist can help you treat pain and improve your ability to do your daily tasks.
  • A pain management specialist can offer a number of pain treatments.

Sign "release of information" forms so that your doctors can work together as a team.

Learn more

Self-Care

Self-Care

Here are some steps you can take to control and sometimes relieve your ME/CFS symptoms.

  • Manage your activity so that you can be as active as possible without causing your symptoms to get worse.
    • Stay within your energy envelope. This is the amount of energy you have to spend in a day. For each activity you want to do, think about how much energy it will take. This can help you manage your day so that you don't spend too much or too little energy.
    • Pace yourself. Have a plan for how long you will do an activity before you take a break. Don't push yourself to get more done on days you feel well. During and between activities, take rest breaks often. This takes practice. You may find that keeping a diary or using a fitness tracker to track your activities helps.
  • If you have problems sleeping, try to improve your sleep habits.
    • Avoid drinking or eating anything with caffeine after 3 p.m. This includes coffee, tea, cola drinks, and chocolate.
    • Make sure your bedroom is not too hot or too cold, and keep it quiet and dark.
    • Avoid watching TV or using your cell phone, tablet, or computer before bed.
    • Make sure your mattress provides good support.
    • Take naps if you need to. Keep them short, no more than 1 hour, and try not to take them late in the afternoon.
  • If you have problems with your ability to think, remember, or concentrate, you may try finding ways to simplify your daily tasks. For example, have one spot you always put your keys and write down things you need to remember. Also make sure to pace any mental activities like phone calls or reading and writing emails.
  • If you are sensitive to certain foods or chemicals, sound, or light, you may try to avoid those things. Some people may find it helpful to modify their diet and to use eye masks, sunglasses, or earplugs.
  • Consider joining a support group with other people who have ME/CFS. These groups can be a good source of information and tips for what to do to feel better. Your doctor can tell you how to contact a support group.
  • Consider going to counseling. It can help you learn to cope with ME/CFS. It may also help to work with a professional counselor who understands ME/CFS.

Learn more

Medicines

Medicines

Medicines don't cure ME/CFS. But they can help relieve your symptoms.

Over-the-counter (OTC) medicines.

You might take over-the-counter pain relievers and anti-inflammatory drugs. They include acetaminophen (such as Tylenol), ibuprofen (such as Advil or Motrin), and naproxen (such as Aleve). They sometimes relieve joint and muscle pain, headaches, and fevers. Be safe with medicines. Read and follow all instructions on the label. Talk to your doctor if your pain isn't helped by OTC medicine.

Prescription medicines.

These include:

  • Anticonvulsants, also called antiseizure medicines. This type of drug, such as gabapentin or pregabalin, is sometimes prescribed for pain and sleep problems. It seems to work best when used for nerve pain.
  • Antidepressants. These are prescribed to ease depression, anxiety, and pain. They may also help you concentrate more and sleep better.
  • Other medicines, such as fludrocortisone or midodrine. These may help you feel less dizzy or weak when sitting up or standing after lying down.

Learn more

Complementary Treatments

Complementary Treatments

Along with daily self-care and the treatment you get from your doctor, you might find that other treatments help too.

There are safe nontraditional treatments that can relieve pain and stress, ease muscle tension, and help you feel better and healthier.

Some popular complementary treatments include:

  • Acupuncture.
  • Massage therapy.
  • Mind-body techniques like mindfulness, meditation, and yoga.

Some types of yoga may be very intense and cause your symptoms to worsen. Look for a gentle form of yoga. It may be best to start off with short sessions at home so that you can take breaks.

Some people may try different diets, vitamins, or supplements to help manage their symptoms. Talk with your doctor before you try a new diet, vitamin, or supplement. And pay attention to how your body and symptoms respond to it. You can work closely with your doctor to figure out what works best for you.

Learn more

References

References

Citations

  1. Institute of Medicine (2015). Beyond myalgic encephalomyelitis/chronic fatigue syndrome: Redefining an illness. Institute of Medicine. https://www.nap.edu/catalog/19012/beyond-myalgic-encephalomyelitischronic-fatigue-syndrome-redefining-an-illness. Accessed January 31, 2017.

Current as of: October 24, 2023

Author: Ignite Healthwise, LLC Staff

Clinical Review Board
All Healthwise education is reviewed by a team that includes physicians, nurses, advanced practitioners, registered dieticians, and other healthcare professionals.

This information does not replace the advice of a doctor. Ignite Healthwise, LLC, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

© 2024 Ignite Healthwise, LLC. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Ignite Healthwise, LLC.

Related Links

Fibromyalgia Feeling Depressed Depression

<cipublic-spinner variant="large"><span>Loading…</span></cipublic-spinner>

Page Footer

I want to...

Get an ID card File a claim View my claims and EOBs Check coverage under my plan See prescription drug list Find an in-network doctor, dentist, or facility Find a form Find 1095-B tax form information View the Cigna Glossary Contact Cigna

Audiences

Individuals and Families Medicare Employers Brokers Providers

Secure Member Sites

myCigna member portal Health Care Provider portal Cigna for Employers Client Resource Portal Cigna for Brokers

The Cigna Group Information

About Cigna Healthcare Company Profile Careers Newsroom Investors Suppliers The Cigna Group Third Party Administrators International Evernorth

 Cigna. All rights reserved.

Privacy Legal Product Disclosures Cigna Company Names Customer Rights Accessibility Non-Discrimination Notice Language Assistance [PDF] Report Fraud Sitemap Cookie Settings

Disclaimer

Individual and family medical and dental insurance plans are insured by Cigna Health and Life Insurance Company (CHLIC), Cigna HealthCare of Arizona, Inc., Cigna HealthCare of Illinois, Inc., Cigna HealthCare of Georgia, Inc., Cigna HealthCare of North Carolina, Inc., Cigna HealthCare of South Carolina, Inc., and Cigna HealthCare of Texas, Inc. Group health insurance and health benefit plans are insured or administered by CHLIC, Connecticut General Life Insurance Company (CGLIC), or their affiliates (see a listing of the legal entities that insure or administer group HMO, dental HMO, and other products or services in your state). Accidental Injury, Critical Illness, and Hospital Care plans or insurance policies are distributed exclusively by or through operating subsidiaries of Cigna Corporation, are administered by Cigna Health and Life Insurance Company, and are insured by either (i) Cigna Health and Life Insurance Company (Bloomfield, CT); (ii) Life Insurance Company of North America (“LINA”) (Philadelphia, PA); or (iii) New York Life Group Insurance Company of NY (“NYLGICNY”) (New York, NY), formerly known as Cigna Life Insurance Company of New York. The Cigna name, logo, and other Cigna marks are owned by Cigna Intellectual Property, Inc. LINA and NYLGICNY are not affiliates of Cigna.

All insurance policies and group benefit plans contain exclusions and limitations. For availability, costs and complete details of coverage, contact a licensed agent or Cigna sales representative. This website is not intended for residents of New Mexico.

Selecting these links will take you away from Cigna.com to another website, which may be a non-Cigna website. Cigna may not control the content or links of non-Cigna websites. Details