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Home Knowledge Center Wellness Library ado-trastuzumab emtansine

ado-trastuzumab emtansine

Pronunciation: AY doe tras TOOZ ue mab em TAN seen

Brand: Kadcyla

What is the most important information I should know about ado-trastuzumab emtansine?

What is the most important information I should know about ado-trastuzumab emtansine?

Do not use if you are pregnant. Use effective birth control, and tell your doctor if you become pregnant during treatment.

This medicine can cause serious side effects on your liver or heart. Call your doctor at once if you have upper stomach pain, loss of appetite, dark urine, yellowing of your skin or eyes, shortness of breath, cough, swelling, rapid weight gain, fast or pounding heartbeats, dizziness, or if you feel like you might pass out.

What is ado-trastuzumab emtansine?

What is ado-trastuzumab emtansine?

Ado-trastuzumab emtansine is used to treat a HER2-positive breast cancer. This medicine is used both for early breast cancer and for breast cancer that has spread to other parts of the body (metastatic).

Ado-trastuzumab emtansine is usually given after other treatments have failed.

Kadcyla (ado-trastuzumab) should not be used in place of Herceptin (trastuzumab).

Ado-trastuzumab emtansine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving ado-trastuzumab emtansine?

What should I discuss with my healthcare provider before receiving ado-trastuzumab emtansine?

Tell your doctor if you have ever had:

  • heart problems;
  • liver disease (especially hepatitis B or C);
  • bleeding or blood clotting disorder such as hemophilia; or
  • asthma, chronic obstructive pulmonary disease (COPD), sleep apnea, or other breathing disorder.

You may need to have a negative pregnancy test before starting this treatment.

Ado-trastuzumab emtansine can harm an unborn baby if the mother or the father is using this medicine.

  • If you are a woman, do not use ado-trastuzumab emtansine if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 7 months after your last dose.
  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 4 months after your last dose.
  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using ado-trastuzumab emtansine.

Do not breastfeed while using this medicine, and for at least 7 months after your last dose.

How is ado-trastuzumab emtansine given?

How is ado-trastuzumab emtansine given?

Ado-trastuzumab emtansine is given as an infusion into a vein. A healthcare provider will give you this injection.

This medicine must be given slowly, and the infusion can take 30 to 90 minutes to complete.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when ado-trastuzumab emtansine is injected.

Ado-trastuzumab emtansine is usually given once every 3 weeks. Your doctor will determine how long to treat you.

You may need frequent medical tests to be sure this medicine is not causing harmful effects. Your cancer treatments may be delayed based on the results.

What happens if I miss a dose?

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your ado-trastuzumab emtansine injection.

What happens if I overdose?

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving ado-trastuzumab emtansine?

What should I avoid while receiving ado-trastuzumab emtansine?

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

What are the possible side effects of ado-trastuzumab emtansine?

What are the possible side effects of ado-trastuzumab emtansine?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection. Tell your caregiver right away if you feel cold, light-headed, feverish or sweaty, or have chest tightness, rapid heartbeats, or trouble breathing.

Call your doctor at once if you have:

  • easy bruising, unusual bleeding, purple or red spots under your skin;
  • coughing up blood or vomit that looks like coffee grounds;
  • bloody or tarry stools;
  • chest pain, wheezing, dry cough;
  • unusual tiredness, feeling light-headed;
  • pale skin, cold hands and feet;
  • numbness, tingling, or burning pain in your hands or feet;
  • sudden numbness or weakness (especially on one side of the body), severe headache, slurred speech, balance problems;
  • heart problems --swelling in your lower legs, rapid weight gain, feeling short of breath, cough, fast or pounding heartbeat, dizziness, feeling like you might pass out;
  • liver problems --loss of appetite, stomach pain (upper right side), dark urine, jaundice (yellowing of the skin or eyes); or
  • signs of tumor cell breakdown --confusion, weakness, muscle cramps, nausea, vomiting, fast or slow heart rate, decreased urination, tingling in your hands and feet or around your mouth.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

  • easy bruising or bleeding (especially nosebleeds);
  • nausea, constipation;
  • joint or muscle pain;
  • headache; or
  • feeling tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect ado-trastuzumab emtansine?

What other drugs will affect ado-trastuzumab emtansine?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may affect ado-trastuzumab emtansine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Where can I get more information?

Your doctor or pharmacist can provide more information about ado-trastuzumab emtansine.

This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

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