Skip to main navigation Skip to main content Skip to footer For Medicare For Providers For Brokers For Employers Español For Individuals & Families: For Individuals & Families Medical Dental Other Supplemental Explore coverage through work How to Buy Health Insurance Types of Dental Insurance Open Enrollment vs. Special Enrollment See all topics Shop for Medicare plans Member Guide Find a Doctor Log in to myCigna
Home Knowledge Center Wellness Library ampicillin and sulbactam

ampicillin and sulbactam

Pronunciation: am pi SIL in and sul BAK tam

Brand: Unasyn

What is the most important information I should know about ampicillin and sulbactam?

What is the most important information I should know about ampicillin and sulbactam?

You should not use this medicine if you have ever had a severe allergic reaction to any type of penicillin or cephalosporin antibiotic, or if you have had liver problems while using ampicillin and sulbactam.

What is ampicillin and sulbactam?

What is ampicillin and sulbactam?

Ampicillin and sulbactam are penicillin antibiotics that fight bacteria.

Ampicillin and sulbactam is a combination medicine used to treat many different types of infections caused by bacteria.

Ampicillin and sulbactam may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using ampicillin and sulbactam?

What should I discuss with my healthcare provider before using ampicillin and sulbactam?

You should not use this medicine if you are allergic to ampicillin or sulbactam, or if you have ever had

  • a severe allergic reaction to any type of penicillin or cephalosporin antibiotic; or
  • liver problems (hepatitis or jaundice) while using ampicillin and sulbactam.

Tell your doctor if you have ever had:

  • liver disease;
  • mononucleosis (also called "mono");
  • kidney disease;
  • an allergy to any medication; or
  • any other allergies.

Tell your doctor if you are pregnant or breastfeeding.

Do not give this medicine to a child without medical advice.

How should I use ampicillin and sulbactam?

How should I use ampicillin and sulbactam?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Ampicillin and sulbactam is injected into a muscle, or given as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.

Ampicillin and sulbactam must be mixed with a liquid (diluent) before using it. When using injections by yourself, be sure you understand how to properly mix and store the medicine.

After mixing this medicine, you will need to use it within a certain number of hours. This will depend on the diluent and how you store the mixture (at cool room temperature, or in a refrigerator).

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.

Prepare an injection only when you are ready to give it. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

This medicine is usually given every 6 hours for 14 days. Follow your doctor's dosing instructions very carefully.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Ampicillin and sulbactam will not treat a viral infection such as the flu or a common cold.

You may need frequent blood tests to check your liver function.

This medicine can affect the results of certain lab tests for glucose (sugar) in the urine. Tell any doctor who treats you that you are using ampicillin and sulbactam.

Store unmixed ampicillin and sulbactam at room temperature away from moisture and heat.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

What happens if I miss a dose?

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose may cause seizure (convulsions).

What should I avoid while using ampicillin and sulbactam?

What should I avoid while using ampicillin and sulbactam?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

What are the possible side effects of ampicillin and sulbactam?

What are the possible side effects of ampicillin and sulbactam?

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);
  • thrush (white patches inside your mouth or throat);
  • heart problems --fast heartbeats, chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
  • liver problems --nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • signs of a new infection --fever, headache, tiredness, ear pain or drainage, eye pain or redness, cough, skin rash, sores or pimples with pus, joint pain, ongoing neck or back pain, diarrhea, pain or burning when you urinate.

Common side effects may include:

  • diarrhea;
  • rash;
  • swollen, black, or "hairy" tongue;
  • vaginal itching or discharge;
  • pain where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect ampicillin and sulbactam?

What other drugs will affect ampicillin and sulbactam?

Tell your doctor about all your other medicines, especially:

  • allopurinol; or
  • probenecid.

This list is not complete. Other drugs may affect ampicillin and sulbactam, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Where can I get more information?

Your doctor or pharmacist can provide more information about ampicillin and sulbactam.

This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

<cipublic-spinner variant="large"><span>Loading…</span></cipublic-spinner>

Page Footer

I want to...

Get an ID card File a claim View my claims and EOBs Check coverage under my plan See prescription drug list Find an in-network doctor, dentist, or facility Find a form Find 1095-B tax form information View the Cigna Glossary Contact Cigna

Audiences

Individuals and Families Medicare Employers Brokers Providers

Secure Member Sites

myCigna member portal Health Care Provider portal Cigna for Employers Client Resource Portal Cigna for Brokers

Cigna Company Information

About Cigna Company Profile Careers Newsroom Investors Suppliers Third Party Administrators International Evernorth

 Cigna. All rights reserved.

Privacy Legal Product Disclosures Cigna Company Names Customer Rights Accessibility Non-Discrimination Notice [PDF] Language Assistance [PDF] Report Fraud Sitemap

Disclaimer

Individual and family medical and dental insurance plans are insured by Cigna Health and Life Insurance Company (CHLIC), Cigna HealthCare of Arizona, Inc., Cigna HealthCare of Illinois, Inc., and Cigna HealthCare of North Carolina, Inc. Group health insurance and health benefit plans are insured or administered by CHLIC, Connecticut General Life Insurance Company (CGLIC), or their affiliates (see a listing of the legal entities  that insure or administer group HMO, dental HMO, and other products or services in your state). Accidental Injury, Critical Illness, and Hospital Care plans or insurance policies are distributed exclusively by or through operating subsidiaries of Cigna Corporation, are administered by Cigna Health and Life Insurance Company, and are insured by either (i) Cigna Health and Life Insurance Company (Bloomfield, CT); (ii) Life Insurance Company of North America (“LINA”) (Philadelphia, PA); or (iii) New York Life Group Insurance Company of NY (“NYLGICNY”) (New York, NY), formerly known as Cigna Life Insurance Company of New York. The Cigna name, logo, and other Cigna marks are owned by Cigna Intellectual Property, Inc. LINA and NYLGICNY are not affiliates of Cigna.

All insurance policies and group benefit plans contain exclusions and limitations. For availability, costs and complete details of coverage, contact a licensed agent or Cigna sales representative. This website is not intended for residents of New Mexico.

Selecting these links will take you away from Cigna.com to another website, which may be a non-Cigna website. Cigna may not control the content or links of non-Cigna websites. Details