anagrelide

What is the most important information I should know about anagrelide?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What is anagrelide?

Anagrelide is used to treat a blood cell disorder called thrombocythemia (also called thrombocytosis), which occurs when your body produces too many platelet cells.

Anagrelide may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking anagrelide?

Tell your doctor if you have ever had:

• bleeding problems;
• long QT syndrome (in you or a family member);
• heart or lung problems;
• liver disease; or
• an electrolyte imbalance (such as low levels of potassium in your blood).

This medicine may affect fertility (your ability to have children).

How should I take anagrelide?

Your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG) before and during treatment. You may also need frequent blood tests while taking anagrelide.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

If you need surgery, tell the surgeon ahead of time that you are using anagrelide.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

What should I avoid while taking anagrelide?

Ask a doctor or pharmacist before using any medicines for pain, fever, swelling, or cold/flu symptoms. They may contain aspirin or similar ingredients (such as ibuprofen, ketoprofen, or naproxen) which can increase your risk of bleeding.

What are the possible side effects of anagrelide?

• easy bruising or bleeding (nosebleeds, bleeding gums);
• signs of stomach bleeding --bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
• chest pain or pressure;
• fast or pounding heartbeats, fluttering in your chest, and sudden dizziness (like you might pass out);
• shortness of breath;
• swelling in your lower legs; or
• blue colored lips or skin.

Common side effects may include:

• fast heartbeats, chest pain, breathing problems;
• numbness, tingling, burning pain;
• headache, weakness, dizziness;
• stomach pain, gas, indigestion, loss of appetite;
• nausea, vomiting, diarrhea;
• swelling in your hands or feet;
• fever, cough, not feeling well;
• back pain; or
• rash, itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect anagrelide?

Tell your doctor about all your other medicines, especially:

• an antidepressant;
• medicine to improve blood flow;
• a blood thinner (such as warfarin or Coumadin) or other medicine to treat or prevent blood clots;
• NSAIDs (nonsteroidal anti-inflammatory drugs) --aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete. Other drugs may affect anagrelide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about anagrelide.