aspirin and omeprazole

What is the most important information I should know about aspirin and omeprazole?

Omeprazole can cause kidney problems. Tell your doctor if you are urinating less than usual, or if you have blood in your urine.

Omeprazole may cause new or worsening symptoms of lupus. Tell your doctor if you have joint pain and a skin rash on your cheeks or arms that worsens in sunlight.

What is aspirin and omeprazole?

Aspirin and omeprazole is a combination medicine used to help lower the risk of heart problems, strokes, or death in people who have had heart problems caused by blood clots.

Aspirin and omeprazole is also used in people who have had surgery to improve blood flow to the heart and also have another condition that is already being treated with aspirin.

Omeprazole helps reduce the risk of stomach ulcers that may be caused by aspirin, especially in people who are 55 or older, or those who have had stomach ulcers in the past.

Aspirin and omeprazole may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking aspirin and omeprazole?

• you are also allergic to medicines like esomeprazole, lansoprazole, pantoprazole, rabeprazole, Nexium, Prevacid, Protonix, and others;
• you take medicine that contains rilpivirine (Edurant, Complera, Juluca, Odefsey);
• you have had an asthma attack or severe allergic reaction (sneezing, runny or stuffy nose, wheezing, chest pain, shortness of breath) after taking aspirin or another NSAID; or
• if you had breathing problems, kidney problems, or a severe allergic reaction after taking this medicine in the past.

Tell your doctor if you have ever had:

• a bleeding disorder or vitamin K deficiency;
• low levels of magnesium in your blood;
• a habit of drinking more than 3 alcoholic beverages per day;
• liver or kidney disease;
• lupus; or
• if you are of Asian descent.

This medicine may temporarily affect your ability to get pregnant. Talk with your doctor if this concerns you.

How should I take aspirin and omeprazole?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the lowest dose that is effective in treating your condition.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using aspirin and omeprazole.

Omeprazole may affect a drug-screening urine test and you could have false results. Tell the laboratory staff that you use aspirin and omeprazole.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time unless your doctor tells you to.

What happens if I overdose?

Overdose symptoms may include ringing in your ears, increased thirst, muscle pain or weakness, trouble breathing, or feeling cold.

What should I avoid while taking aspirin and omeprazole?

Ask a doctor or pharmacist before using over-the-counter medicines. They may contain ingredients similar to aspirin or omeprazole.

What are the possible side effects of aspirin and omeprazole?

• severe nausea, vomiting, stomach pain, or diarrhea that is watery or bloody;
• bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
• easy bruising, unusual bleeding (such as a nosebleed), or any bleeding that will not stop;
• sudden pain or trouble moving your hip, wrist, or back;
• kidney problems --fever, rash, nausea, loss of appetite, joint pain, urinating less than usual, blood in your urine, weight gain;
• liver problems --stomach pain, itching, dark urine, jaundice (yellowing of the skin or eyes);
• low magnesium --dizziness, fast or irregular heart rate, tremors (shaking) or jerking muscle movements, feeling jittery, muscle cramps, muscle spasms in your hands and feet, cough or choking feeling; or
• new or worsening symptoms of lupus --joint pain, and a skin rash on your cheeks or arms that worsens in sunlight.

Taking this medicine long-term may cause you to develop stomach growths called fundic gland polyps. Talk with your doctor about this risk.

If you use this medicine for longer than 3 years, you could develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition if you develop it.

Common side effects may include:

• heartburn, stomach pain, indigestion;
• nausea, diarrhea; or
• chest pain (may happen when you eat).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect aspirin and omeprazole?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your current medicines. Many drugs can affect aspirin and omeprazole, especially:

• clopidogrel;
• digoxin;
• methotrexate;
• rifampin;
• St. John's wort;
• ticagrelor;
• a diuretic or "water pill;" or
• NSAIDs (nonsteroidal anti-inflammatory drugs) --aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete and many other drugs may affect aspirin and omeprazole. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about aspirin and omeprazole.