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benznidazole

Pronunciation: benz NID a zole

What is the most important information I should know about benznidazole?

What is the most important information I should know about benznidazole?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What is benznidazole?

What is benznidazole?

Benznidazole is an antibiotic that is used to treat Chagas disease in children ages 2 through 12 years. Chagas disease (also called American trypanosomiasis) is an infection caused by a parasite common to the areas of South America, Central America and Mexico.

Benznidazole was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people responded to this medicine, but further studies are needed.

Benznidazole may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking benznidazole?

What should I discuss with my healthcare provider before taking benznidazole?

You should not use benznidazole if you are allergic to it, or if:

  • you are allergic to similar antibiotics such as metronidazole, secnidazole, or tinidazole; or
  • you have taken disulfiram (Antabuse) within the past 2 weeks.

You may need to have a negative pregnancy test before starting this treatment.

Benznidazole may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.

This medicine may affect fertility (ability to have children) in men. It is not known whether this effect would be permanent.

You should not breastfeed while using benznidazole.

Benznidazole should not be given to a child younger than 2 years old.

How should I take benznidazole?

How should I take benznidazole?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may take benznidazole with or without food.

You may need to break a tablet to get the correct dose. For a young child who cannot swallow a tablet whole, you may dissolve the tablet in water to create a liquid for the child to drink.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Benznidazole doses are based on weight in children. Your child's dose needs may change if the child gains or loses weight.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking benznidazole?

What should I avoid while taking benznidazole?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of benznidazole?

What are the possible side effects of benznidazole?

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Stop using benznidazole and call your doctor at once if you have:

  • numbness, tingling, or burning pain in your hands or feet (may continue for several months); or
  • low blood cell counts --fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Common side effects may include:

  • low white blood cell counts;
  • rash or itching;
  • stomach pain, nausea, vomiting, loss of appetite;
  • headache; or
  • weight loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect benznidazole?

What other drugs will affect benznidazole?

Other drugs may affect benznidazole, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Where can I get more information?

Your pharmacist can provide more information about benznidazole.

This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

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