cefuroxime (oral/injection)

What is the most important information I should know about cefuroxime?

Cefuroxime can cause serious or life-threatening allergic reactions. Tell your doctor if you have an allergy to an antibiotic, especially penicillin.

What is cefuroxime?

Cefuroxime is a cephalosporin (SEF a low spor in) antibiotic that is used to treat bacterial infections of the ear, nose, throat, lungs, skin, bones, joints, bladder, or kidneys. Cefuroxime is also used to treat gonorrhea, sepsis, or early Lyme disease.

Cefuroxime injection is sometimes given before and after a surgery to prevent infection.

Cefuroxime may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using cefuroxime?

• cefuroxime, cefadroxil, cefdinir, cefoxitin, cefprozil, ceftriaxone, cephalexin, Keflex, Omnicef, and others;
• avibactam, relebactam, sulbactam, tazobactam, vaborbactam, and others; or
• amoxicillin (Amoxil, Augmentin, Moxatag), ampicillin, dicloxacillin, oxacillin, penicillin, and others.

Tell your doctor if you have ever had:

• an stomach or intestinal disorder such as colitis;
• kidney disease;
• liver disease; or
• heart problems.

Cefuroxime oral suspension may contain phenylalanine and could be harmful if you have phenylketonuria (PKU).

Tell your doctor if you are pregnant or breastfeeding.

If you are being treated for gonorrhea: Having gonorrhea during pregnancy may increase the risk of complications including premature birth, low birth weight, or gonorrhea developing the newborn. The benefit of treating this condition may outweigh any risks to the baby.

Not approved for use by anyone younger than 3 months old.

How should I use cefuroxime?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Cefuroxime oral is taken by mouth.

Tell your doctor if a child taking cefuroxime has trouble swallowing the medicine.

Cefuroxime oral may be given as a single dose to treat gonorrhea. For most other infections, cefuroxime oral is usually given for 7 to 10 days, or for 20 days to treat early Lyme disease.

Your dose needs may change if you switch from tablets to oral suspension. Follow your doctor's dosing instructions very carefully.

Cefuroxime injection is given into a muscle or a vein, usually for 5 to 10 days.

Ask your doctor or pharmacist if you don't understand how to use an injection.

You may need to mix cefuroxime with a liquid (diluent) before using it. Use only the diluent your doctor has recommended.

Prepare an injection only when you are ready to give it. Call your pharmacist if the medicine has changed colors or has particles in it.

Do not reuse a needle or syringe. Place them in a puncture-proof "sharps" container and dispose of it following state or local laws. Keep out of the reach of children and pets.

Keep using this medicine even if your symptoms quickly improve. Skipping doses could make your infection resistant to medication. Cefuroxime will not treat a viral infection (flu or a common cold).

Cefuroxime can affect the results of certain medical tests. Tell any doctor who treats you that you are using cefuroxime.

After mixing cefuroxime for injection, you will need to use it within a certain number of hours or days. This will depend on the diluent and how you store the mixture (at room temperature or in a refrigerator). Be sure you understand how to properly mix and store the medicine if using injections at home.

After thawing, you may store the cefuroxime injection at room temperature for up to 24 hours, or in a refrigerator for up to 7 days. Do not refreeze the medicine once it has been thawed.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use take doses at one time.

What happens if I overdose?

Overdose symptoms may include seizure.

What should I avoid while using cefuroxime?

Antibiotic medicines can cause diarrhea. Tell your doctor if you have diarrhea that is watery or bloody.

What are the possible side effects of cefuroxime?

• severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);
• jaundice (yellowing of the skin or eyes);
• fever, chills;
• a seizure; or
• chest pain.

Common side effects may include:

• nausea, vomiting, diarrhea;
• flu-like symptoms;
• vaginal itching or discharge; or
• diaper rash (in people using the oral suspension).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect cefuroxime?

Tell your doctor about all your other medicines, especially:

• any other IV antibiotic;
• probenecid;
• a diuretic or "water pill";
• a blood thinner --warfarin, Coumadin, Jantoven; or
• a stomach acid reducer --esomeprazole, famotidine, Nexium, Pepcid, Prevacid, Prilosec, Tagamet, Zantac, and others.

This list is not complete. Other drugs may affect cefuroxime, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about cefuroxime.