Cilastatin/Imipenem/Relebactam Injection 500 mg/500 mg/250 mg

Instructions

This medicine is given as an IV injection into a vein.

This medicine should be given over 30 minutes.

Read and make sure you understand the instructions for measuring dose and using syringe. If you have any questions, talk to your doctor, nurse, or pharmacist.

The medicine needs to be mixed before being injected.

Always inspect the medicine before using.

The liquid should be clear or light yellow.

Do not use the medicine if it contains any particles or if it has changed color.

Keep medicine at room temperature. Protect from light.

Keep the medicine in its original container.

Never use any medicine that has expired.

Discard any remaining medicine after your dose is given.

Discard any unused, mixed medicine after 2 hours at room temperature or 24 hours in refrigerator.

Use this medicine at the same time each day.

Space doses evenly to keep a steady amount of medicine in the body.

You or a family member can be trained to give this medicine at home.

If you miss a dose, contact your doctor for instructions.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

Tell your doctor if symptoms do not get better or if they get worse.

Keep using this medicine for the full number of days that it is prescribed. Do not stop the medicine even if you start to feel better.

If you have diabetes and use urine glucose tests, this medicine may cause incorrect results. Please check with your doctor before making any changes to your diabetes treatment plan.

It is very important that you follow your doctor's instructions for all blood tests.

Cautions

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

Do not use the medication any more than instructed.

Contact your doctor if you develop any signs of a new infection such as fever, cough, sore throat, or chills.

Speak with your health care provider before receiving any vaccinations.

Please tell your doctor if you have moderate to severe diarrhea while on this medicine. Do not treat the diarrhea with over-the-counter diarrhea medicine.

Tell the doctor or pharmacist if you are pregnant, planning to be pregnant, or breastfeeding.

Ask your pharmacist how to properly throw away used needles or syringes.

Do not share this medicine with anyone who has not been prescribed this medicine.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

• diarrhea
• headaches
• pain, redness, swelling near injection
• yeast infection of mouth
• vaginal itching or yeast infection
• vomiting

Call your doctor or get medical help right away if you notice any of these more serious side effects:

• confusion
• severe, watery or bloody diarrhea
• fast or irregular heart beats
• new or worsening movement problems
• seizures
• severe stomach or bowel pain
• blood in stool
• unusual or unexplained tiredness or weakness
• dark urine
• yellowing of the eyes

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.