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clozapine
clozapine
What is the most important information I should know about clozapine?
What is the most important information I should know about clozapine?
Clozapine affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, sore throat, weakness, or lack of energy.
Clozapine can increase your risk of seizure, especially at high doses. Avoid any activity that could be dangerous if you have a seizure or lose consciousness.
Clozapine can cause serious heart problems. Call your doctor right away if you have chest pain, trouble breathing, fast or pounding heartbeats or sudden dizziness.
Clozapine is not approved for use in older adults with dementia-related psychosis.
What is clozapine?
What is clozapine?
Clozapine is an antipsychotic medicine that is used in adults to treat schizophrenia after other treatments have failed. Clozapine is available only from a certified pharmacy under a special program.
Clozapine is also used in adults to reduce the risk of suicidal behavior in people with schizophrenia or similar disorders.
Clozapine may also be used for purposes not listed in this medication guide.
What should I discuss with my healthcare provider before taking clozapine?
What should I discuss with my healthcare provider before taking clozapine?
Clozapine may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.
You should not take this medicine if you are allergic to clozapine.
Tell your doctor if you have ever had:
- heart problems, high blood pressure,
- a heart attack or stroke (including "mini-stroke");
- long QT syndrome (in you or a family member);
- an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);
- a seizure, head injury, or brain tumor;
- diabetes, or risk factors such as being overweight or having a family history of diabetes;
- high cholesterol or triglycerides;
- constipation or problems with your bowel movements;
- liver or kidney disease;
- an enlarged prostate or urination problems;
- glaucoma;
- malnourishment or dehydration; or
- if you smoke.
Taking antipsychotic medicine in the last 3 months of pregnancy may cause breathing problems, feeding problems, or withdrawal symptoms in the newborn. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you get pregnant, tell your doctor right away. Do not stop taking clozapine without your doctor's advice.
You should not breastfeed while using clozapine.
How should I take clozapine?
How should I take clozapine?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
You may take clozapine with or without food.
Shake the oral suspension (liquid) for 10 seconds before you measure a dose. Measure a dose with the supplied measuring device (not a kitchen spoon).
Remove an orally disintegrating tablet from the package only when you are ready to take the medicine. Place the tablet in your mouth and allow it to dissolve, without chewing. Swallow several times as the tablet dissolves.
Clozapine affects your immune system and can have long lasting effects on your body. You may get infections more easily, even serious or fatal infections. You may need frequent medical tests while using this medicine and for a short time after your last dose.
You should not stop using clozapine suddenly. Follow your doctor's instructions about tapering your dose.
If you start taking clozapine again after 2 or more days off the medicine, you may need to use a lower dose than when you stopped. Follow your doctor's dosing instructions very carefully.
Your doctor may recommend you use a laxative while taking clozapine. Use only the type of laxative your doctor recommends.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
If you miss taking clozapine for more than 2 days in a row, call your doctor before you start taking it again.
Get your prescription refilled before you run out of medicine completely.
What happens if I overdose?
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include drowsiness, confusion, fast heartbeats, feeling light-headed, weak or shallow breathing, drooling, choking, or seizure.
What should I avoid while taking clozapine?
What should I avoid while taking clozapine?
Do not drink alcohol. Dangerous side effects or death could occur.
Avoid coffee, tea, cola, energy drinks or other sources of caffeine.
Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.
What are the possible side effects of clozapine?
What are the possible side effects of clozapine?
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
You may get infections more easily, even serious or fatal infections. Call your doctor right away if you have signs of infection such as:
- fever, flu-like symptoms, extreme weakness;
- mouth sores, skin sores;
- new or worsening cough, trouble breathing;
- pain or burning when you urinate; or
- vaginal itching or discharge.
Further doses may be delayed until your infection clears up.
High doses or long-term use of clozapine can cause a serious movement disorder that may not be reversible. The longer you use clozapine, the more likely you are to develop this disorder, especially if you are a woman or an older adult.
Clozapine can increase your risk of seizure, especially at high doses. Avoid any activity that could be dangerous if you have a seizure or lose consciousness.
Call your doctor at once if you have:
- uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);
- a seizure (blackout or convulsions);
- severe constipation;
- dry or hard bowel movements, or painful gas;
- nausea, vomiting, stomach pain or bloating;
- heart problems --chest pain, fast or pounding heartbeats, fluttering in your chest, slow heartbeats, shortness of breath, and sudden dizziness (like you might pass out);
- liver problems --loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
- severe nervous system reaction --very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out; or
- signs of a blood clot in the lung --chest pain, sudden cough, wheezing, rapid breathing, coughing up blood.
Untreated constipation may lead to serious bowel complications, hospitalization, or death. Tell your doctor right away if you are not having bowel movements at least 3 times per week.
Common side effects may include:
- weight gain;
- dizziness, tremor;
- fast heart rate;
- headache, drowsiness;
- nausea, constipation;
- dry mouth, or increased salivation;
- vision problems; or
- fever, increased sweating.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect clozapine?
What other drugs will affect clozapine?
When you start or stop taking clozapine, your doctor may need to adjust the doses of any other medicines you take on a regular basis.
Clozapine can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.
Using clozapine with other drugs that make you drowsy or slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, cold or allergy medicine, or medicine for anxiety or seizures.
Many drugs can affect clozapine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.
Where can I get more information?
Where can I get more information?
Your pharmacist can provide more information about clozapine.
This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.
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