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Home Knowledge Center Wellness Library complement C1 esterase inhibitor

complement C1 esterase inhibitor

Pronunciation: KOM ple ment C1 ES ter ase in HIB it or

Brand: Berinert, Cinryze, Haegarda

What is the most important information I should know about complement C1 esterase inhibitor?

What is the most important information I should know about complement C1 esterase inhibitor?

You should not use this medicine if have ever had a life-threatening allergic reaction to complement C1 esterase inhibitor.

What is complement C1 esterase inhibitor?

What is complement C1 esterase inhibitor?

Complement C1 esterase inhibitor is a man-made form of a protein in blood that helps control swelling in the body. People with a condition called hereditary angioedema do not have enough of this protein. Hereditary angioedema can cause attacks of swelling and symptoms such as stomach problems or trouble breathing.

Complement C1 esterase inhibitor is used in people with hereditary angioedema. Berinert is used to treat attacks of angioedema. Cinryze and Haegarda are used to prevent attacks of angioedema.

Complement C1 esterase inhibitor may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using complement C1 esterase inhibitor?

What should I discuss with my healthcare provider before using complement C1 esterase inhibitor?

You should not use this medicine if have ever had a life-threatening allergic reaction to complement C1 esterase inhibitor.

Tell your doctor if you have ever had:

  • a stroke or blood clot;
  • heart problems; or
  • an "in-dwelling" catheter.

Tell your doctor if you are pregnant or breast-feeding.

Complement C1 esterase inhibitor is made from donated human plasma and may contain viruses or other infectious agents. Donated plasma is tested and treated to reduce the risk of contamination, but there is still a small possibility it could transmit disease. Ask your doctor about any possible risk.

How should I use complement C1 esterase inhibitor?

How should I use complement C1 esterase inhibitor?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Cinryze or Berinert are given as an infusion into a vein. Haegarda is injected under the skin. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Prepare an injection only when you are ready to give it. Ask your doctor or pharmacist if you don't understand all instructions.

Seek emergency medical attention after using Berinert to treat an angioedema attack.

Storing unopened vials: Store in a refrigerator or at cool room temperature and use until expiration date. Protect from light and do not freeze.

Each vial (bottle) is for one use only. Throw it away after one use, even if there is still medicine left inside.

After mixing Cinryze, use the injection right away or store at room temperature and use within 3 hours.

After mixing Berinert or Haegarda, use the injection right away or store at room temperature and use within 8 hours.

Complement C1 esterase inhibitor contains no preservative. Once you have pierced the rubber top of a vial with a needle, you must use that vial right away or throw it away.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

What happens if I miss a dose?

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose of Cinryze or Haegarda.

Keep Cinryze or Haegarda on hand at all times to prevent angioedema, especially while traveling.

What happens if I overdose?

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid after using complement C1 esterase inhibitor?

What should I avoid after using complement C1 esterase inhibitor?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of complement C1 esterase inhibitor?

What are the possible side effects of complement C1 esterase inhibitor?

Get emergency medical help if you have signs of an allergic reaction: hives; chest tightness, fast heartbeats, feeling light-headed; wheezing or difficult breathing, blue lips or gums; or swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • sudden numbness or weakness on one side of the body;
  • pain, swelling, warmth, or redness in an arm or leg;
  • sudden severe headache, confusion, problems with vision, speech, or balance;
  • chest pain while taking deep breaths; or
  • fast heart rate.

Common side effects may include:

  • unusual or unpleasant taste in your mouth;
  • headache, dizziness;
  • nausea, vomiting;
  • pain, bruising, itching, swelling, bleeding, warmth, or a hard lump where the medicine was injected;
  • stuffy nose, sore throat;
  • rash; or
  • fever.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect complement C1 esterase inhibitor?

What other drugs will affect complement C1 esterase inhibitor?

Tell your doctor about all your other medicines, especially:

  • testosterone; or
  • birth control pills.

This list is not complete. Other drugs may affect complement C1 esterase inhibitor, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Where can I get more information?

Your doctor or pharmacist can provide more information about complement C1 esterase inhibitor.

This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

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