Skip to main navigation Skip to main content Skip to footer For Medicare For Providers For Brokers For Employers Español For Individuals & Families: For Individuals & Families Medical Dental Other Supplemental Explore coverage through work How to Buy Health Insurance Types of Dental Insurance Open Enrollment vs. Special Enrollment See all topics Shop for Medicare plans Member Guide Find a Doctor Log in to myCigna
Home Knowledge Center Wellness Library desipramine

desipramine

Pronunciation: des IP ra meen

Norpramin

slide 1 of 13, Norpramin,

50 mg, round, green, imprinted with NORPRAMIN 50

Image of Norpramin
slide 1 of 13

Desipramine Hydrochloride

slide 2 of 13, Desipramine Hydrochloride,

25 mg, round, white, imprinted with GG 64

Image of Desipramine Hydrochloride
slide 2 of 13

Desipramine Hydrochloride

slide 3 of 13, Desipramine Hydrochloride,

50 mg, round, white, imprinted with GG 65

Image of Desipramine Hydrochloride
slide 3 of 13

Desipramine Hydrochloride

slide 4 of 13, Desipramine Hydrochloride,

75 mg, round, white, imprinted with GG 166

Image of Desipramine Hydrochloride
slide 4 of 13

Desipramine Hydrochloride

slide 5 of 13, Desipramine Hydrochloride,

100 mg, round, white, imprinted with GG 167

Image of Desipramine Hydrochloride
slide 5 of 13

Desipramine Hydrochloride

slide 6 of 13, Desipramine Hydrochloride,

150 mg, round, white, imprinted with GG 168

Image of Desipramine Hydrochloride
slide 6 of 13

Desipramine Hydrochloride

slide 7 of 13, Desipramine Hydrochloride,

10 mg, round, white, imprinted with 341

Image of Desipramine Hydrochloride
slide 7 of 13

Desipramine Hydrochloride

slide 8 of 13, Desipramine Hydrochloride,

25 mg, round, blue, imprinted with 342

Image of Desipramine Hydrochloride
slide 8 of 13

Desipramine Hydrochloride

slide 9 of 13, Desipramine Hydrochloride,

50 mg, round, blue, imprinted with 343

Image of Desipramine Hydrochloride
slide 9 of 13

Desipramine Hydrochloride

slide 10 of 13, Desipramine Hydrochloride,

75 mg, round, blue, imprinted with 344

Image of Desipramine Hydrochloride
slide 10 of 13

Desipramine Hydrochloride

slide 11 of 13, Desipramine Hydrochloride,

100 mg, round, blue, imprinted with 345

Image of Desipramine Hydrochloride
slide 11 of 13

Desipramine Hydrochloride

slide 12 of 13, Desipramine Hydrochloride,

10 mg, round, white, imprinted with GG 63

Image of Desipramine Hydrochloride
slide 12 of 13

Norpramin

slide 13 of 13, Norpramin,

10 mg, round, blue, imprinted with 68-7

Image of Norpramin
slide 13 of 13
What is the most important information I should know about desipramine?

What is the most important information I should know about desipramine?

You should not use this medicine if you have recently had a heart attack.

Do not use this medicine within 14 days before or after taking an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

What is desipramine?

What is desipramine?

Desipramine is a tricyclic antidepressant that is used to treat symptoms of depression.

Desipramine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking desipramine?

What should I discuss with my healthcare provider before taking desipramine?

You should not use desipramine if you are allergic to it, or:

  • if you have recently had a heart attack.

Do not use desipramine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. Do not take an MAOI for at least 2 weeks after you stop taking desipramine.

Tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone.

Tell your doctor if you have ever had:

  • bipolar disorder (manic-depression) or schizophrenia;
  • mental illness or psychosis;
  • liver disease;
  • heart disease;
  • a family history of sudden death related to a heart rhythm disorder;
  • a heart attack, stroke, or seizures;
  • a thyroid disorder;
  • glaucoma; or
  • problems with urination.

Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with desipramine and cause a serious condition called serotonin syndrome.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Tell your doctor if you are pregnant or breastfeeding.

Desipramine is not approved for use by anyone younger than 18 years old.

How should I take desipramine?

How should I take desipramine?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

If you need surgery, tell your surgeon you currently use this medicine. You may need to stop for a short time.

It may take up to 3 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

Do not stop using desipramine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of desipramine can be fatal.

Overdose symptoms may include irregular heartbeats, feeling like you might pass out, seizures, or coma.

What should I avoid while taking desipramine?

What should I avoid while taking desipramine?

Do not drink alcohol. Dangerous side effects or death can occur when alcohol is combined with desipramine.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Avoid exposure to sunlight or tanning beds. Desipramine can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What are the possible side effects of desipramine?

What are the possible side effects of desipramine?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • easy bruising, unusual bleeding, purple or red spots under your skin;
  • a light-headed feeling, like you might pass out;
  • confusion, hallucinations, unusual thoughts or behavior;
  • blurred vision, tunnel vision, eye pain or swelling, seeing halos around lights;
  • new or worsening chest pain, pounding heartbeats or fluttering in your chest;
  • sudden numbness or weakness, problems with vision, speech, or balance;
  • fever, sore throat;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum);
  • painful or difficult urination;
  • upper stomach pain, loss of appetite, jaundice (yellowing of the skin or eyes);
  • a seizure; or
  • severe nervous system reaction --very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Serious side effects may be more likely in older adults and those who are ill or debilitated.

Common side effects may include:

  • increased blood pressure;
  • tingly feeling, weakness, lack of coordination;
  • dry mouth, loss of appetite, nausea, vomiting;
  • breast swelling (in men or women); or
  • weight gain or weight loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect desipramine?

What other drugs will affect desipramine?

Using desipramine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Many drugs can affect desipramine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Where can I get more information?

Your pharmacist can provide more information about desipramine.

This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

<cipublic-spinner variant="large"><span>Loading…</span></cipublic-spinner>

Page Footer

I want to...

Get an ID card File a claim View my claims and EOBs Check coverage under my plan See prescription drug list Find an in-network doctor, dentist, or facility Find a form Find 1095-B tax form information View the Cigna Glossary Contact Cigna

Audiences

Individuals and Families Medicare Employers Brokers Providers

Secure Member Sites

myCigna member portal Health Care Provider portal Cigna for Employers Client Resource Portal Cigna for Brokers

Cigna Company Information

About Cigna Company Profile Careers Newsroom Investors Suppliers Third Party Administrators International Evernorth

 Cigna. All rights reserved.

Privacy Legal Product Disclosures Cigna Company Names Customer Rights Accessibility Non-Discrimination Notice [PDF] Language Assistance [PDF] Report Fraud Sitemap

Disclaimer

Individual and family medical and dental insurance plans are insured by Cigna Health and Life Insurance Company (CHLIC), Cigna HealthCare of Arizona, Inc., Cigna HealthCare of Illinois, Inc., and Cigna HealthCare of North Carolina, Inc. Group health insurance and health benefit plans are insured or administered by CHLIC, Connecticut General Life Insurance Company (CGLIC), or their affiliates (see a listing of the legal entities  that insure or administer group HMO, dental HMO, and other products or services in your state). Accidental Injury, Critical Illness, and Hospital Care plans or insurance policies are distributed exclusively by or through operating subsidiaries of Cigna Corporation, are administered by Cigna Health and Life Insurance Company, and are insured by either (i) Cigna Health and Life Insurance Company (Bloomfield, CT); (ii) Life Insurance Company of North America (“LINA”) (Philadelphia, PA); or (iii) New York Life Group Insurance Company of NY (“NYLGICNY”) (New York, NY), formerly known as Cigna Life Insurance Company of New York. The Cigna name, logo, and other Cigna marks are owned by Cigna Intellectual Property, Inc. LINA and NYLGICNY are not affiliates of Cigna.

All insurance policies and group benefit plans contain exclusions and limitations. For availability, costs and complete details of coverage, contact a licensed agent or Cigna sales representative. This website is not intended for residents of New Mexico.

Selecting these links will take you away from Cigna.com to another website, which may be a non-Cigna website. Cigna may not control the content or links of non-Cigna websites. Details