Skip to main navigation Skip to main content Skip to footer For Medicare For Providers For Brokers For Employers Español For Individuals & Families: For Individuals & Families Medical Dental Other Supplemental Explore coverage through work How to Buy Health Insurance Types of Dental Insurance Open Enrollment vs. Special Enrollment See all topics Shop for Medicare plans Member Guide Find a Doctor Log in to myCigna
Home Knowledge Center Wellness Library dextromethorphan and promethazine

dextromethorphan and promethazine

Pronunciation: dex troe me THOR fan and pro METH a zeen

Brand: Promethazine DM

What is the most important information I should know about dextromethorphan and promethazine?

What is the most important information I should know about dextromethorphan and promethazine?

Promethazine can slow the breathing, which has caused death in very young children. Do not use this medicine in a child younger than 2 years old. Follow all directions when giving the medicine to a child 2 years or older.

Do not use dextromethorphan and promethazine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

What is dextromethorphan and promethazine?

What is dextromethorphan and promethazine?

Dextromethorphan is a cough suppressant. Promethazine is an antihistamine.

Dextromethorphan and promethazine is a combination medicine used to treat cough, stuffy nose, runny nose, and sneezing caused by colds or allergies.

This medicine is for use in adults and children at least 2 years old.

Dextromethorphan and promethazine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking dextromethorphan and promethazine?

What should I discuss with my healthcare provider before taking dextromethorphan and promethazine?

You should not use this medicine if you are allergic to dextromethorphan or promethazine, or if you have:

  • asthma or other breathing problems; or
  • an allergy to medicines similar to promethazine (chlorpromazine, fluphenazine, prochlorperazine, thioridazine, and others).

Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others.

Tell your doctor if you have ever had:

  • chronic obstructive pulmonary disease (COPD), sleep apnea, or other breathing disorder;
  • a seizure;
  • eczema;
  • bone marrow depression;
  • glaucoma;
  • a stomach ulcer;
  • blockage in your stomach or intestines;
  • a bladder obstruction or other urination problems;
  • an enlarged prostate;
  • liver disease;
  • heart problems; or
  • if you are on bed rest or otherwise debilitated.

Tell your doctor if you are pregnant or breastfeeding.

Taking this medicine during the last 2 weeks of pregnancy may increase the risk of bleeding in the newborn baby.

Ask a doctor before giving this medicine to a child younger than 12 years old.

How should I take dextromethorphan and promethazine?

How should I take dextromethorphan and promethazine?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Do not use this medicine in a child younger than 2 years old, and carefully follow all dosing directions about use in a child 2 years or older. Promethazine can slow the breathing, which has caused death in very young children.

Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon).

This medicine can affect the results of certain medical tests, and may cause false results on a pregnancy test. Tell the doctor or laboratory staff if you have taken dextromethorphan and promethazine in the past few days.

Call your doctor if your symptoms do not improve, or if they get worse.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

What happens if I miss a dose?

Dextromethorphan and promethazine is used when needed. If you are on a dosing schedule, skip any missed dose. Do not use two doses at one time.

What happens if I overdose?

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include overactive reflexes, feeling restless or confused, slow breathing, dilated pupils, or fainting.

What should I avoid while taking dextromethorphan and promethazine?

What should I avoid while taking dextromethorphan and promethazine?

Avoid driving, riding a bike, or any other hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Ask a doctor or pharmacist before using other cough or cold medicines that may contain dextromethorphan.

Avoid drinking alcohol.

Avoid sunlight, and wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What are the possible side effects of dextromethorphan and promethazine?

What are the possible side effects of dextromethorphan and promethazine?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • weak or shallow breathing, breathing that stops during sleep;
  • unusual restlessness or excitement;
  • uncontrolled muscle movements in your neck, tongue, or eyes;
  • fast, slow, or uneven heart rate;
  • hallucinations, ringing in your ears;
  • a seizure;
  • fever, chills, weakness;
  • easy bruising, unusual bleeding;
  • yellowing of your skin or eyes; or
  • severe nervous system reaction --very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Common side effects may include:

  • drowsiness, dizziness;
  • dry mouth, nose, or throat;
  • blurred vision;
  • nausea, vomiting; or
  • loss of coordination.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect dextromethorphan and promethazine?

What other drugs will affect dextromethorphan and promethazine?

Using dextromethorphan and promethazine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your other medicines, especially:

  • an antidepressant;
  • a barbiturate such as phenobarbital;
  • bronchodilator asthma medication;
  • cold or allergy medicine (Benadryl and others);
  • medicine to treat Parkinson's disease;
  • medicine to treat overactive bladder; or
  • medicine to treat stomach problems, motion sickness, or irritable bowel syndrome.

This list is not complete. Other drugs may affect dextromethorphan and promethazine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Where can I get more information?

Your pharmacist can provide more information about dextromethorphan and promethazine.

This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

<cipublic-spinner variant="large"><span>Loading…</span></cipublic-spinner>

Page Footer

I want to...

Get an ID card File a claim View my claims and EOBs Check coverage under my plan See prescription drug list Find an in-network doctor, dentist, or facility Find a form Find 1095-B tax form information View the Cigna Glossary Contact Cigna

Audiences

Individuals and Families Medicare Employers Brokers Providers

Secure Member Sites

myCigna member portal Health Care Provider portal Cigna for Employers Client Resource Portal Cigna for Brokers

Cigna Company Information

About Cigna Company Profile Careers Newsroom Investors Suppliers Third Party Administrators International Evernorth

 Cigna. All rights reserved.

Privacy Legal Product Disclosures Cigna Company Names Customer Rights Accessibility Non-Discrimination Notice [PDF] Language Assistance [PDF] Report Fraud Sitemap

Disclaimer

Individual and family medical and dental insurance plans are insured by Cigna Health and Life Insurance Company (CHLIC), Cigna HealthCare of Arizona, Inc., Cigna HealthCare of Illinois, Inc., and Cigna HealthCare of North Carolina, Inc. Group health insurance and health benefit plans are insured or administered by CHLIC, Connecticut General Life Insurance Company (CGLIC), or their affiliates (see a listing of the legal entities  that insure or administer group HMO, dental HMO, and other products or services in your state). Accidental Injury, Critical Illness, and Hospital Care plans or insurance policies are distributed exclusively by or through operating subsidiaries of Cigna Corporation, are administered by Cigna Health and Life Insurance Company, and are insured by either (i) Cigna Health and Life Insurance Company (Bloomfield, CT); (ii) Life Insurance Company of North America (“LINA”) (Philadelphia, PA); or (iii) New York Life Group Insurance Company of NY (“NYLGICNY”) (New York, NY), formerly known as Cigna Life Insurance Company of New York. The Cigna name, logo, and other Cigna marks are owned by Cigna Intellectual Property, Inc. LINA and NYLGICNY are not affiliates of Cigna.

All insurance policies and group benefit plans contain exclusions and limitations. For availability, costs and complete details of coverage, contact a licensed agent or Cigna sales representative. This website is not intended for residents of New Mexico.

Selecting these links will take you away from Cigna.com to another website, which may be a non-Cigna website. Cigna may not control the content or links of non-Cigna websites. Details