Skip to main navigation Skip to main content Skip to footer For Medicare For Providers For Brokers For Employers Español For Individuals & Families: For Individuals & Families Medical Dental Other Supplemental Explore coverage through work How to Buy Health Insurance Types of Dental Insurance Open Enrollment vs. Special Enrollment See all topics Shop for Medicare plans Member Guide Find a Doctor Log in to myCigna
Home Knowledge Center Wellness Library dornase alfa (inhalation)

dornase alfa (inhalation)

Pronunciation: DOOR nase AL fa

Brand: Pulmozyme

What is the most important information I should know about dornase alfa?

What is the most important information I should know about dornase alfa?

Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

What is dornase alfa?

What is dornase alfa?

Dornase alfa is used in people with cystic fibrosis to thin mucus in the airways. This may help improve lung function and lower the risk of infections.

Dornase alfa may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using dornase alfa?

What should I discuss with my healthcare provider before using dornase alfa?

You should not use this medicine if you are allergic to dornase alfa or other Chinese Hamster Ovary cell products.

Do not give this medicine to a child without medical advice.

Tell your doctor if you are pregnant or breastfeeding.

How should I use dornase alfa?

How should I use dornase alfa?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Use dornase alfa regularly to get the most benefit.

Read and follow all Instructions for Use. Ask your doctor or pharmacist if you need help.

To use the solution with most nebulizers:

  • Pour the medicine into the nebulizer chamber. Attach the mouthpiece or face mask, then attach the chamber to the compressor. Sit upright and place the mouthpiece into your mouth or put on the face mask. Turn on the compressor.
  • Breathe slowly and evenly until there is no more mist and the drug chamber is empty.
  • Clean the nebulizer after each use. On certain nebulizer systems, you may need to change the handset after 90 uses. Follow the directions that came with your nebulizer.

Do not dilute or mix dornase alfa with any other drugs in the nebulizer.

Tell the doctor if your child has trouble breathing in or out while using the nebulizer.

Each ampule is for one use only. Throw it away after one use, even if there is still medicine left inside.

Store dornase alfa ampules in the refrigerator, protected from light. Keep unused ampules in the protective foil pouch.

If needed, you may store an ampule at room temperature for short periods of time (up to a total of 60 hours). Protect from heat and light.

Call your pharmacist if the medicine looks cloudy or has changed colors.

What happens if I miss a dose?

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

What happens if I overdose?

Overdose is unlikely when used as directed, and is not expected to cause harmful effects.

What should I avoid while using dornase alfa?

What should I avoid while using dornase alfa?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of dornase alfa?

What are the possible side effects of dornase alfa?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have worsened breathing problems.

Common side effects may include:

  • sore throat;
  • chest pain, trouble breathing;
  • changes in the sound of your voice;
  • rash;
  • eye redness; or
  • fever.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect dornase alfa?

What other drugs will affect dornase alfa?

Other drugs may affect dornase alfa, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Where can I get more information?

Where can I get more information?

Your pharmacist can provide more information about dornase alfa.

This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

<cipublic-spinner variant="large"><span>Loading…</span></cipublic-spinner>

Page Footer

I want to...

Get an ID card File a claim View my claims and EOBs Check coverage under my plan See prescription drug list Find an in-network doctor, dentist, or facility Find a form Find 1095-B tax form information View the Cigna Glossary Contact Cigna


Individuals and Families Medicare Employers Brokers Providers

Secure Member Sites

myCigna member portal Health Care Provider portal Cigna for Employers Client Resource Portal Cigna for Brokers

The Cigna Group Information

About The Cigna Group Company Profile Careers Newsroom Investors Suppliers The Cigna Group Third Party Administrators International Evernorth

 Cigna. All rights reserved.

Privacy Legal Product Disclosures Cigna Company Names Customer Rights Accessibility Non-Discrimination Notice Language Assistance [PDF] Report Fraud Sitemap Cookie Settings


Individual and family medical and dental insurance plans are insured by Cigna Health and Life Insurance Company (CHLIC), Cigna HealthCare of Arizona, Inc., Cigna HealthCare of Illinois, Inc., Cigna HealthCare of Georgia, Inc., Cigna HealthCare of North Carolina, Inc., Cigna HealthCare of South Carolina, Inc., and Cigna HealthCare of Texas, Inc. Group health insurance and health benefit plans are insured or administered by CHLIC, Connecticut General Life Insurance Company (CGLIC), or their affiliates (see a listing of the legal entities that insure or administer group HMO, dental HMO, and other products or services in your state). Accidental Injury, Critical Illness, and Hospital Care plans or insurance policies are distributed exclusively by or through operating subsidiaries of Cigna Corporation, are administered by Cigna Health and Life Insurance Company, and are insured by either (i) Cigna Health and Life Insurance Company (Bloomfield, CT); (ii) Life Insurance Company of North America (“LINA”) (Philadelphia, PA); or (iii) New York Life Group Insurance Company of NY (“NYLGICNY”) (New York, NY), formerly known as Cigna Life Insurance Company of New York. The Cigna name, logo, and other Cigna marks are owned by Cigna Intellectual Property, Inc. LINA and NYLGICNY are not affiliates of Cigna.

All insurance policies and group benefit plans contain exclusions and limitations. For availability, costs and complete details of coverage, contact a licensed agent or Cigna sales representative. This website is not intended for residents of New Mexico.

Selecting these links will take you away from to another website, which may be a non-Cigna website. Cigna may not control the content or links of non-Cigna websites. Details