Skip to main navigation Skip to main content Skip to footer For Medicare For Providers For Brokers For Employers Español For Individuals & Families: For Individuals & Families Medical Dental Other Supplemental Explore coverage through work How to Buy Health Insurance Types of Dental Insurance Open Enrollment vs. Special Enrollment See all topics Shop for Medicare plans Member Guide Find a Doctor Log in to myCigna
Home Knowledge Center Wellness Library duloxetine

duloxetine

Pronunciation: du LOX e teen

Brand: Cymbalta, Drizalma Sprinkle, Irenka

Cymbalta

slide 1 of 31, Cymbalta,

20 mg, capsule, green, imprinted with 20 mg, LILLY 3235

Image of Cymbalta
slide 1 of 31

Cymbalta

slide 2 of 31, Cymbalta,

30 mg, capsule, blue/white, imprinted with Lilly 3240, 30 mg

Image of Cymbalta
slide 2 of 31

DULoxetine Hydrochloride

slide 3 of 31, DULoxetine Hydrochloride,

20 mg, capsule, green, imprinted with TEVA, 7542

Image of DULoxetine Hydrochloride
slide 3 of 31

DULoxetine Hydrochloride

slide 4 of 31, DULoxetine Hydrochloride,

30 mg, capsule, blue/white, imprinted with TEVA, 7543

Image of DULoxetine Hydrochloride
slide 4 of 31

DULoxetine Hydrochloride

slide 5 of 31, DULoxetine Hydrochloride,

60 mg, capsule, blue/green, imprinted with TEVA, 7544

Image of DULoxetine Hydrochloride
slide 5 of 31

DULoxetine Hydrochloride

slide 6 of 31, DULoxetine Hydrochloride,

20 mg, capsule, blue, imprinted with 2890

Image of DULoxetine Hydrochloride
slide 6 of 31

DULoxetine Hydrochloride

slide 7 of 31, DULoxetine Hydrochloride,

30 mg, capsule, blue/gray, imprinted with LOGO 2891

Image of DULoxetine Hydrochloride
slide 7 of 31

DULoxetine Hydrochloride

slide 8 of 31, DULoxetine Hydrochloride,

20 mg, capsule, green, imprinted with X, 01

Image of DULoxetine Hydrochloride
slide 8 of 31

DULoxetine Hydrochloride

slide 9 of 31, DULoxetine Hydrochloride,

30 mg, capsule, blue/white, imprinted with X, 02

Image of DULoxetine Hydrochloride
slide 9 of 31

DULoxetine Hydrochloride

slide 10 of 31, DULoxetine Hydrochloride,

60 mg, capsule, blue/green, imprinted with X 03

Image of DULoxetine Hydrochloride
slide 10 of 31

DULoxetine Hydrochloride

slide 11 of 31, DULoxetine Hydrochloride,

20 mg, capsule, yellow, imprinted with B, 746

Image of DULoxetine Hydrochloride
slide 11 of 31

DULoxetine Hydrochloride

slide 12 of 31, DULoxetine Hydrochloride,

30 mg, capsule, green/white, imprinted with B, 747

Image of DULoxetine Hydrochloride
slide 12 of 31

DULoxetine Hydrochloride

slide 13 of 31, DULoxetine Hydrochloride,

60 mg, capsule, brown/green, imprinted with B, 748

Image of DULoxetine Hydrochloride
slide 13 of 31

DULoxetine Hydrochloride

slide 14 of 31, DULoxetine Hydrochloride,

20 mg, capsule, green, imprinted with 20 mg, LILLY 3235

Image of DULoxetine Hydrochloride
slide 14 of 31

DULoxetine Hydrochloride

slide 15 of 31, DULoxetine Hydrochloride,

30 mg, capsule, blue/white, imprinted with Lilly 3240, 30 mg

Image of DULoxetine Hydrochloride
slide 15 of 31

Cymbalta

slide 16 of 31, Cymbalta,

60 mg, capsule, blue/yellow, imprinted with Lilly 3237, 60 mg

Image of Cymbalta
slide 16 of 31

DULoxetine Hydrochloride

slide 17 of 31, DULoxetine Hydrochloride,

30 mg, capsule, blue/white, imprinted with X, 02

Image of DULoxetine Hydrochloride
slide 17 of 31

DULoxetine Hydrochloride

slide 18 of 31, DULoxetine Hydrochloride,

20 mg, capsule, clear/green, imprinted with LOGO, 007

Image of DULoxetine Hydrochloride
slide 18 of 31

DULoxetine Hydrochloride

slide 19 of 31, DULoxetine Hydrochloride,

20 mg, capsule, green, imprinted with H, 190

Image of DULoxetine Hydrochloride
slide 19 of 31

DULoxetine Hydrochloride

slide 20 of 31, DULoxetine Hydrochloride,

20 mg, capsule, white, imprinted with 557, 20mg

Image of DULoxetine Hydrochloride
slide 20 of 31

DULoxetine Hydrochloride

slide 21 of 31, DULoxetine Hydrochloride,

30 mg, capsule, blue/white, imprinted with H, 191

Image of DULoxetine Hydrochloride
slide 21 of 31

DULoxetine Hydrochloride

slide 22 of 31, DULoxetine Hydrochloride,

30 mg, capsule, green/white, imprinted with 558, 30mg

Image of DULoxetine Hydrochloride
slide 22 of 31

DULoxetine Hydrochloride

slide 23 of 31, DULoxetine Hydrochloride,

30 mg, capsule, clear/white, imprinted with LOGO, 008

Image of DULoxetine Hydrochloride
slide 23 of 31

DULoxetine Hydrochloride

slide 24 of 31, DULoxetine Hydrochloride,

40 mg, capsule, white, imprinted with LU, H25

Image of DULoxetine Hydrochloride
slide 24 of 31

DULoxetine Hydrochloride

slide 25 of 31, DULoxetine Hydrochloride,

60 mg, capsule, gray/white, imprinted with LOGO 2892

Image of DULoxetine Hydrochloride
slide 25 of 31

DULoxetine Hydrochloride

slide 26 of 31, DULoxetine Hydrochloride,

60 mg, capsule, blue/clear, imprinted with LOGO, 009

Image of DULoxetine Hydrochloride
slide 26 of 31

DULoxetine Hydrochloride

slide 27 of 31, DULoxetine Hydrochloride,

60 mg, capsule, blue/green, imprinted with H, 192

Image of DULoxetine Hydrochloride
slide 27 of 31

DULoxetine Hydrochloride

slide 28 of 31, DULoxetine Hydrochloride,

60 mg, capsule, blue/white, imprinted with 559, 60mg

Image of DULoxetine Hydrochloride
slide 28 of 31

DULoxetine Hydrochloride

slide 29 of 31, DULoxetine Hydrochloride,

20 mg, capsule, green/white, imprinted with 241, 20 mg

Image of DULoxetine Hydrochloride
slide 29 of 31

DULoxetine Hydrochloride

slide 30 of 31, DULoxetine Hydrochloride,

30 mg, capsule, blue/green, imprinted with 242, 30 mg

Image of DULoxetine Hydrochloride
slide 30 of 31

DULoxetine Hydrochloride

slide 31 of 31, DULoxetine Hydrochloride,

60 mg, capsule, blue/white, imprinted with 243, 60 mg

Image of DULoxetine Hydrochloride
slide 31 of 31
What is the most important information I should know about duloxetine?

What is the most important information I should know about duloxetine?

People with depression or mental illness may have thoughts about suicide. Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Tell your doctor right away if you have any sudden changes in mood or behavior, or thoughts about suicide.

Do not stop using duloxetine without first asking your doctor.

What is duloxetine?

What is duloxetine?

Duloxetine is a serotonin and norepinephrine reuptake inhibitor antidepressant (SNRI).

Duloxetine is used to treat major depressive disorder in adults. Duloxetine is also used to treat general anxiety disorder in adults and children at least 7 years old.

Duloxetine is also used in adults to treat diabetic nerve pain or chronic muscle or joint pain (such as low back pain and osteoarthritis pain).

Some brands of duloxetine are also used to treat fibromyalgia (a chronic pain disorder). Drizalma is for treating fibromyalgia only in adults. Cymbalta may be used to treat fibromyalgia in adults and children at least 13 years old.

Duloxetine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking duloxetine?

What should I discuss with my healthcare provider before taking duloxetine?

You should not use duloxetine if you are allergic to it.

Do not take duloxetine within 5 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine. A dangerous drug interaction could occur.

Tell your doctor if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with duloxetine could cause a serious condition called serotonin syndrome.

Not approved for use by anyone younger than 7 years old.

Tell your doctor if you have ever had:

  • heart problems, high blood pressure;
  • liver or kidney disease;
  • slow digestion;
  • a seizure;
  • bleeding problems;
  • sexual problems;
  • narrow-angle glaucoma;
  • bipolar disorder (manic depression);
  • drug addiction or suicidal thoughts; or
  • if you drink large amounts of alcohol.

People with depression or mental illness may have thoughts about suicide. Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Stay alert to changes in your mood or symptoms. Your family or caregivers should also watch for sudden changes in your behavior.

Taking this medicine during pregnancy could harm the baby, but stopping the medicine may not be safe for you. Do not start or stop duloxetine without asking your doctor.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of duloxetine on the baby.

If you are breastfeeding, tell your doctor if you notice drowsiness, feeding problems, and slow weight gain in the nursing baby.

How should I take duloxetine?

How should I take duloxetine?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Taking duloxetine in higher doses or more often than prescribed will not make it more effective, and may increase side effects.

Swallow the capsule whole and do not crush, chew, break, or open it.

Take with or without food.

Your blood pressure will need to be checked often.

Tell your doctor if you have any changes in sexual function, such as loss of interest in sex, trouble having an orgasm, or (in men) problems with erections or ejaculation. Some sexual problems can be treated.

Your symptoms may not improve for up to 4 weeks.

Do not stop using duloxetine suddenly, or you could have unpleasant symptoms (such as agitation, confusion, tingling or electric shock feelings). Ask your doctor before stopping the medicine.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include vomiting, dizziness or drowsiness, seizures, fast heartbeats, fainting, or coma.

What should I avoid while taking duloxetine?

What should I avoid while taking duloxetine?

Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen, naproxen, Advil, Aleve, Motrin, and others. Using an NSAID with duloxetine may cause you to bruise or bleed easily.

Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Drinking alcohol may increase your risk of liver damage, especially if you take Drizalma.

What are the possible side effects of duloxetine?

What are the possible side effects of duloxetine?

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Tell your doctor right away if you have new or sudden changes in mood or behavior, including new or worse depression or anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, more active or talkative, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • pounding heartbeats or fluttering in your chest;
  • a light-headed feeling, like you might pass out;
  • easy bruising, unusual bleeding;
  • vision changes;
  • painful or difficult urination;
  • liver problems --right-sided upper stomach pain, itching, dark urine, jaundice (yellowing of the skin or eyes);
  • low blood sodium --headache, confusion, problems with thinking or memory, weakness, feeling unsteady; or
  • manic episodes --racing thoughts, increased energy, decreased need for sleep, risk-taking behavior, being agitated or talkative.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Common side effects may include:

  • drowsiness;
  • nausea, constipation, loss of appetite;
  • dry mouth; or
  • increased sweating.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect duloxetine?

What other drugs will affect duloxetine?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can affect duloxetine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all other medicines you use.

Where can I get more information?

Where can I get more information?

Your pharmacist can provide more information about duloxetine.

This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

<cipublic-spinner variant="large"><span>Loading…</span></cipublic-spinner>

Page Footer

I want to...

Get an ID card File a claim View my claims and EOBs Check coverage under my plan See prescription drug list Find an in-network doctor, dentist, or facility Find a form Find 1095-B tax form information View the Cigna Glossary Contact Cigna

Audiences

Individuals and Families Medicare Employers Brokers Providers

Secure Member Sites

myCigna member portal Health Care Provider portal Cigna for Employers Client Resource Portal Cigna for Brokers

Cigna Company Information

About Cigna Company Profile Careers Newsroom Investors Suppliers Third Party Administrators International Evernorth

 Cigna. All rights reserved.

Privacy Legal Product Disclosures Cigna Company Names Customer Rights Accessibility Non-Discrimination Notice [PDF] Language Assistance [PDF] Report Fraud Sitemap

Disclaimer

Individual and family medical and dental insurance plans are insured by Cigna Health and Life Insurance Company (CHLIC), Cigna HealthCare of Arizona, Inc., Cigna HealthCare of Illinois, Inc., and Cigna HealthCare of North Carolina, Inc. Group health insurance and health benefit plans are insured or administered by CHLIC, Connecticut General Life Insurance Company (CGLIC), or their affiliates (see a listing of the legal entities  that insure or administer group HMO, dental HMO, and other products or services in your state). Accidental Injury, Critical Illness, and Hospital Care plans or insurance policies are distributed exclusively by or through operating subsidiaries of Cigna Corporation, are administered by Cigna Health and Life Insurance Company, and are insured by either (i) Cigna Health and Life Insurance Company (Bloomfield, CT); (ii) Life Insurance Company of North America (“LINA”) (Philadelphia, PA); or (iii) New York Life Group Insurance Company of NY (“NYLGICNY”) (New York, NY), formerly known as Cigna Life Insurance Company of New York. The Cigna name, logo, and other Cigna marks are owned by Cigna Intellectual Property, Inc. LINA and NYLGICNY are not affiliates of Cigna.

All insurance policies and group benefit plans contain exclusions and limitations. For availability, costs and complete details of coverage, contact a licensed agent or Cigna sales representative. This website is not intended for residents of New Mexico.

Selecting these links will take you away from Cigna.com to another website, which may be a non-Cigna website. Cigna may not control the content or links of non-Cigna websites. Details