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Home Knowledge Center Wellness Library dupilumab

dupilumab

Pronunciation: doo PIL us mab

Brand: Dupixent

What is the most important information I should know about dupilumab?

What is the most important information I should know about dupilumab?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What is dupilumab?

What is dupilumab?

Dupilumab is used to treat moderate-to-severe eczema (atopic dermatitis) that cannot be controlled with topical medicines applied to the skin. Dupilumab is used for eczema in adults and children at least 6 years old.

Dupilumab is also used together with other medications to treat moderate-to-severe asthma that is not controlled with other asthma medicines. Dupilumab is used for asthma in adults and children at least 12 years old.

Dupilumab is used only in adults to treat a condition called chronic rhinosinusitis (long-term sinus inflammation) that is associated with nasal polyps.

Dupilumab may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using dupilumab?

What should I discuss with my healthcare provider before using dupilumab?

You should not use dupilumab if you are allergic to it.

Dupilumab should not be given to a child younger than 12 years old to treat asthma, or younger than 6 years old to treat eczema.

Tell your doctor if you have ever had:

  • eye problems;
  • a parasite infection (such as roundworms or tapeworms); or
  • if you are scheduled to receive any vaccine.

If you use dupilumab to treat eczema or chronic rhinosinusitis with nasal polyposis, tell your doctor if you also have asthma.

Tell your doctor if you are pregnant or breastfeeding.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of dupilumab on the baby.

How should I use dupilumab?

How should I use dupilumab?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Dupilumab is not a rescue medicine for asthma attacks. Use only fast-acting inhalation medicine for an attack. Seek medical attention if your breathing problems get worse quickly, or if you think your asthma medications are not working as well.

Dupilumab is injected under the skin, usually once every 2 to 4 weeks. Your first dose may be given in 2 injections.

A healthcare provider may teach you how to properly use the medication by yourself. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.

Do not shake the prefilled syringe or injection pen. Prepare your injection only when you are ready to give it. Do not use if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.

Store this medicine in the original carton in the refrigerator. Protect from light and do not freeze.

Take a syringe or pen out of the refrigerator and let it reach room temperature for 30 to 45 minutes before injecting your dose. Leave the needle cap on until you are ready to inject your dose.

You may store a prefilled syringe or injection pen at cool room temperature for up to 14 days. Throw the medicine away if not used within 14 days. Do not put it back into the refrigerator.

Each prefilled syringe or injection pen is for one use only. Throw it away after one use, even if there is still medicine left inside.

Use a needle and syringe or pen only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

If you also use other medications to treat eczema or asthma, do not change your doses or stop using the other medications without your doctor's advice.

What happens if I miss a dose?

What happens if I miss a dose?

If you miss your injection by 7 days or less, use the missed dose as soon as you remember and then go back to your regular injection schedule.

If you are more than 7 days late for the injection:

  • For the every-other-week injection schedule: Skip the missed dose and use the medicine at your next scheduled injection time.
  • For the every-4-weeks schedule: Start a new dosing schedule on the day you use the missed injection and use your next injection 4 weeks later.

Do not use two doses at one time.

What happens if I overdose?

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using dupilumab?

What should I avoid while using dupilumab?

Do not receive a "live" vaccine while using dupilumab. The vaccine may not work as well during this time, and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

What are the possible side effects of dupilumab?

What are the possible side effects of dupilumab?

Get emergency medical help if you have signs of an allergic reaction: hives, rash, itching; fever, swollen glands, joint pain; feeling light-headed, difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • new or worsening eye pain or discomfort;
  • vision changes;
  • watery eyes (your eyes may be more sensitive to light);
  • feeling like something is in your eye; or
  • blood vessel inflammation --fever, chest pain, trouble breathing, skin rash, numbness or prickly feeling in your arms or legs.

Common side effects may include:

  • pain, swelling, burning, or irritation where an injection was given;
  • blood vessel inflammation;
  • eye redness or itching, puffy eyelids;
  • stomach pain, nausea, vomiting;
  • sore throat;
  • tooth pain;
  • sleep problems (insomnia);
  • joint pain; or
  • cold sores or fever blisters on your lips or in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect dupilumab?

What other drugs will affect dupilumab?

Tell your doctor about all your other medicines, especially:

  • an oral, inhaled, or topical steroid medicine; or
  • any medicine to treat asthma.

This list is not complete. Other drugs may affect dupilumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Where can I get more information?

Your pharmacist can provide more information about dupilumab.

This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

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