Skip to main navigation Skip to main content Skip to footer For Medicare For Providers For Brokers For Employers Español For Individuals & Families: For Individuals & Families Medical Dental Other Supplemental Explore coverage through work How to Buy Health Insurance Types of Dental Insurance Open Enrollment vs. Special Enrollment See all topics Shop for Medicare plans Member Guide Find a Doctor Log in to myCigna
Home Knowledge Center Wellness Library elapegademase

elapegademase

Pronunciation: EL a peg AD e mase

Brand: Revcovi

What is the most important information I should know about elapegademase?

What is the most important information I should know about elapegademase?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What is elapegademase?

What is elapegademase?

Elapegademase is a man-made form of an enzyme called adenosine deaminase (ADA). ADA is important in the body for preventing the buildup of certain proteins harmful to the white blood cells that help your body fight infections.

Elapegademase is used to replace ADA in adults and children with adenosine deaminase severe combined immune deficiency (ADA-SCID).

ADA-SCID is a lack of immunity to infections that might not cause illness in someone with a healthy immune system. Certain infections (such as pneumonia, chronic diarrhea, or serious skin rash) can be serious or even fatal in people with ADA-SCID.

ADA-SCID can also slow the growth or development of an infant or young child affected with this condition.

Elapegademase may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using elapegademase?

What should I discuss with my healthcare provider before using elapegademase?

Tell your doctor if you have ever used a medication called Adagen (pegademase bovine).

Also tell your doctor if you have had severe thrombocytopenia (low levels of platelets in blood).

Your doctor should check your progress on a regular basis if you use elapegademase during pregnancy.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

How is elapegademase given?

How is elapegademase given?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Elapegademase is injected into a muscle. A healthcare provider can teach you how to properly use the medication by yourself.

Elapegademase is usually given once every 7 days. Follow your doctor's dosing instructions very carefully.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.

Prepare an injection only when you are ready to give it. Do not use if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.

Elapegademase doses are based on weight. Your dose needs may change if you gain or lose weight.

You may need frequent medical tests. Even if you have no symptoms, tests can help your doctor determine if this medicine is effective.

It may take 2 to 6 months before you receive the full benefit of using elapegademase. Keep using the medication regularly to get the most benefit.

Do not shake the medication bottle or you may ruin the medicine.

Store in the refrigerator, do not freeze. Throw away the medicine if it has become frozen.

Each vial (bottle) is for one use only. Throw it away after one use, even if there is still medicine left inside.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

What happens if I miss a dose?

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose.

What happens if I overdose?

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using elapegademase?

What should I avoid while using elapegademase?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

What are the possible side effects of elapegademase?

What are the possible side effects of elapegademase?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • bleeding where the medicine was injected;
  • other unusual bleeding (nosebleeds, bleeding gums);
  • a seizure; or
  • pale or yellowed skin, dark colored urine; or
  • confusion or weakness.

The following symptoms may be signs of infection, which may indicate that elapegademase is not an effective treatment for you. Tell your doctor if you have:

  • fever, chills, unusual tiredness;
  • sore throat, sinus pain, swollen glands;
  • skin warmth or swelling;
  • stomach cramps, vomiting, or diarrhea;
  • blood in your urine or stools;
  • painful or difficult urination;
  • breathing problems, cough with mucus;
  • sores or white patches in your mouth or on your skin;
  • problems with balance or walking; or
  • problems with your teeth or gums.

Common side effects may include:

  • vomiting; or
  • cough.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect elapegademase?

What other drugs will affect elapegademase?

Other drugs may affect elapegademase, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Where can I get more information?

Your doctor or pharmacist can provide more information about elapegademase.

This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

<cipublic-spinner variant="large"><span>Loading…</span></cipublic-spinner>

Page Footer

I want to...

Get an ID card File a claim View my claims and EOBs Check coverage under my plan See prescription drug list Find an in-network doctor, dentist, or facility Find a form Find 1095-B tax form information View the Cigna Glossary Contact Cigna

Audiences

Individuals and Families Medicare Employers Brokers Providers

Secure Member Sites

myCigna member portal Health Care Provider portal Cigna for Employers Client Resource Portal Cigna for Brokers

Cigna Company Information

About Cigna Company Profile Careers Newsroom Investors Suppliers Third Party Administrators International Evernorth

 Cigna. All rights reserved.

Privacy Legal Product Disclosures Cigna Company Names Customer Rights Accessibility Non-Discrimination Notice [PDF] Language Assistance [PDF] Report Fraud Sitemap

Disclaimer

Individual and family medical and dental insurance plans are insured by Cigna Health and Life Insurance Company (CHLIC), Cigna HealthCare of Arizona, Inc., Cigna HealthCare of Illinois, Inc., and Cigna HealthCare of North Carolina, Inc. Group health insurance and health benefit plans are insured or administered by CHLIC, Connecticut General Life Insurance Company (CGLIC), or their affiliates (see a listing of the legal entities  that insure or administer group HMO, dental HMO, and other products or services in your state). Accidental Injury, Critical Illness, and Hospital Care plans or insurance policies are distributed exclusively by or through operating subsidiaries of Cigna Corporation, are administered by Cigna Health and Life Insurance Company, and are insured by either (i) Cigna Health and Life Insurance Company (Bloomfield, CT); (ii) Life Insurance Company of North America (“LINA”) (Philadelphia, PA); or (iii) New York Life Group Insurance Company of NY (“NYLGICNY”) (New York, NY), formerly known as Cigna Life Insurance Company of New York. The Cigna name, logo, and other Cigna marks are owned by Cigna Intellectual Property, Inc. LINA and NYLGICNY are not affiliates of Cigna.

All insurance policies and group benefit plans contain exclusions and limitations. For availability, costs and complete details of coverage, contact a licensed agent or Cigna sales representative. This website is not intended for residents of New Mexico.

Selecting these links will take you away from Cigna.com to another website, which may be a non-Cigna website. Cigna may not control the content or links of non-Cigna websites. Details