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Home Knowledge Center Wellness Library emicizumab

emicizumab

Pronunciation: EM a SIZ ue mab

Brand: Hemlibra

What is the most important information I should know about emicizumab?

What is the most important information I should know about emicizumab?

Emicizumab can cause unwanted blood clots when used together with a bypassing agent such as FEIBA. This can damage small blood vessels in your arms and legs, brain, kidneys, lungs, or other organs.

Tell your doctor if you use a bypassing agent or factor VIII. You will most likely need to stop using it the day before you begin using emicizumab.

If you use emicizumab and a bypassing agent together, call your doctor at once if you have any of these symptoms: weakness, confusion, stomach or back pain, vomiting, decreased urination, chest pain, trouble breathing, coughing up blood, swelling or redness in your arms or legs, eye pain, or vision problems.

What is emicizumab?

What is emicizumab?

Emicizumab functions in place of a natural blood-clotting factor that is missing in people with hemophilia A. Emicizumab works as a "bridge" between other clotting factors to replace missing factor VIII.

Emicizumab is for adults and children with hemophilia A, with or without factor VIII inhibitors. Emicizumab is used to help prevent bleeding episodes or make them occur less often.

Emicizumab will not stop a bleeding episode that has already begun.

Emicizumab may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using emicizumab?

What should I discuss with my healthcare provider before using emicizumab?

You should not use emicizumab if you are allergic to it.

Tell your doctor if you use factor VIII or a bypassing agent such as FEIBA (or "aPCC"; activated prothrombin complex concentrate). Emicizumab can cause unwanted blood clots when used together with aPCC. These blood clots can damage small blood vessels in your arms and legs, brain, kidneys, lungs, or other organs.

You will most likely need to stop using bypassing agents the day before you begin using emicizumab. But you may keep using factor VIII for the first week of using emicizumab.

if your doctor tells you to keep using a bypassing agent, you may need to limit your emicizumab dose to more than 100 units/kilogram per 24 hours. Follow all instructions carefully.

Follow your doctor's instructions about using emicizumab if you are pregnant. It is not known whether this medicine will harm an unborn baby. Control of bleeding episodes is very important during pregnancy. The benefit of preventing these episodes may outweigh any risks to the baby.

If you are not pregnant, use effective birth control to prevent pregnancy while using this medicine.

It is not known whether emicizumab passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.

How is emicizumab given?

How is emicizumab given?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Emicizumab is injected under the skin every 1 to 4 weeks. A healthcare provider may teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.

You will need a syringe and needle to draw emicizumab out of the vial (bottle). You will need a separate needle to inject the medicine into your skin. Use only the type of syringe and needles recommended by your pharmacist to inject emicizumab.

Do not shake the medication bottle. Prepare your dose only when you are ready to give an injection. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

Do not allow a child younger than 7 years old to self-inject this medicine without help from an adult.

Emicizumab can interfere with certain blood-clotting tests. Tell any doctor who treats you that you are using emicizumab.

Store this medicine in the original carton in a refrigerator. Protect from light and do not freeze.

You may store an unopened vial (bottle) at room temperature for a short time. If not used within 7 days, return the vial to the refrigerator.

Once you open and puncture the vial, use the medicine right away. Do not save it for later use. Throw away the vial after one use, even if there is still medicine left inside.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

What happens if I miss a dose?

What happens if I miss a dose?

Use the missed dose as soon as you remember. Then go back to your usual once-weekly schedule and use the next dose on your regular injection day. Do not use two doses at one time.

What happens if I overdose?

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using emicizumab?

What should I avoid while using emicizumab?

Avoid injecting this medicine into a mole or into skin that is scarred, bruised, red, tender, hard, or broken.

What are the possible side effects of emicizumab?

What are the possible side effects of emicizumab?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

If you also use a bypassing agent, call your doctor right away if you have any of these side effects:

  • headache, weakness, confusion;
  • feeling light-headed or unusually sick;
  • back pain, little or no urination;
  • stomach pain, vomiting;
  • chest pain, feeling short of breath, coughing up blood;
  • swelling or redness in your arms or legs;
  • eye pain or swelling, vision problems;
  • numbness in your face; or
  • yellowing of your skin or eyes.

Common side effects may include:

  • headache;
  • joint pain; or
  • pain, swelling, burning, or irritation where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect emicizumab?

What other drugs will affect emicizumab?

Other drugs may affect emicizumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Where can I get more information?

Your pharmacist can provide more information about emicizumab.

This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

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