What should I discuss with my healthcare provider before taking fluoxetine and olanzapine?
You should not use this medicine if you also take pimozide or thioridazine, or if you take other forms of fluoxetine or olanzapine (such as Prozac, Rapiflux, Sarafem, Selfemra, or Zyprexa).
Do not use this medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine. Do not take an MAO inhibitor within 5 weeks after you stop taking fluoxetine and olanzapine.
Fluoxetine and olanzapine may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.
Tell your doctor if you have ever had:
- Alzheimer's disease:
- liver disease;
- narrow-angle glaucoma;
- heart problems;
- high or low blood pressure;
- low white blood cell (WBC) counts;
- a seizure;
- bleeding problems;
- breast cancer;
- a stroke, including "mini-stroke" or "TIA";
- diabetes, high cholesterol or triglycerides;
- bowel obstruction, or severe constipation;
- electroconvulsive therapy (ECT);
- an enlarged prostate; or
- trouble swallowing.
Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with fluoxetine and olanzapine and cause a serious condition called serotonin syndrome.
Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.
Ask your doctor about taking this medicine if you are pregnant. Taking an SSRI antidepressant during late pregnancy may cause serious medical complications in the baby. However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant. Do not start or stop taking this medicine without your doctor's advice.
If you are pregnant, your name may be listed on a pregnancy registry to track the effects of fluoxetine and olanzapine on the baby.
It may be harder for you to get pregnant while you are using this medicine.
If you are breastfeeding, tell your doctor if you notice fussiness, drowsiness, feeding problems, weight loss, or unusual muscle movements in the nursing baby.
Fluoxetine and olanzapine is not approved for use by anyone younger than 10 years old.