hyaluronidase and trastuzumab

What is the most important information I should know about hyaluronidase and trastuzumab?

What is hyaluronidase and trastuzumab?

Hyaluronidase is a genetically designed protein. Trastuzumab is a cancer medicine.

Hyaluronidase and trastuzumab is a combination medicine used to treat certain types of breast cancer.

Hyaluronidase and trastuzumab may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving hyaluronidase and trastuzumab?

Tell your doctor if you have ever had:

• heart problems;
• high blood pressure; or
• if you have recently had an infection.

If you become pregnant while using this medicine or within 7 months after you stop, your name may be listed on a pregnancy registry to track the effects of hyaluronidase and trastuzumab on the baby.

How is hyaluronidase and trastuzumab given?

This medicine is injected under the skin, usually once every 3 weeks.

A healthcare provider will give you this injection.

Hyaluronidase and trastuzumab is usually given for 1 year, or until your body no longer responds to the medicine.

You may need frequent medical tests to be sure this medicine is not causing harmful effects. Your cancer treatments may be delayed based on the results.

What happens if I miss a dose?

What happens if I overdose?

Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving hyaluronidase and trastuzumab?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of hyaluronidase and trastuzumab?

Some side effects may occur during the injection. Tell your caregiver right away if you feel dizzy, nauseated, feverish, chilled, short of breath, or if you have diarrhea, a rash, chest pain, swelling in your face, or trouble breathing.

• new or worsening cough, wheezing, shortness of breath or rapid breathing;
• swelling in your face or lower legs, rapid weight gain;
• fast or pounding heartbeats, fluttering in your chest;
• a light-headed feeling, like you might pass out;
• blisters or ulcers in your mouth, red or swollen gums, trouble swallowing;
• fluid build-up in the lungs --pain when you breathe, feeling short of breath while lying down, gasping for breath, cough with foamy mucus; or
• low blood cell counts --fever, sore throat, tiredness, skin sores, pale skin, cold hands and feet, feeling light-headed.

Common side effects may include:

• nausea, vomiting, diarrhea;
• fever, chills, tiredness;
• cough, breathing problems;
• swelling;
• hair loss;
• flushing (sudden warmth, redness, or tingly feeling);
• headache, muscle or joint pain;
• cold symptoms such as stuffy nose, sneezing, sore throat;
• sleep problems (insomnia);
• rash; or
• pain, burning, itching, swelling, warmth redness, bruising, bleeding, skin changes, or a hard lump where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect hyaluronidase and trastuzumab?

Other drugs may affect hyaluronidase and trastuzumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about hyaluronidase and trastuzumab.