hydrochlorothiazide and captopril

What is the most important information I should know about hydrochlorothiazide and captopril?

If you have diabetes, do not use hydrochlorothiazide and captopril together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo).

What is hydrochlorothiazide and captopril?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Captopril is in a group of drugs called ACE inhibitors. ACE stands for angiotensin converting enzyme. Captopril lowers blood pressure and also relieves symptoms of fluid retention.

Hydrochlorothiazide and captopril is a combination medicine used to treat hypertension (high blood pressure).

Hydrochlorothiazide and captopril may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking hydrochlorothiazide and captopril?

• you are unable to urinate;
• you are allergic to sulfa drugs; or
• you are allergic to any other ACE inhibitor, such as benazepril, enalapril, fosinopril, lisinopril, quinapril, ramipril, trandolapril, and others.

If you have diabetes, do not use hydrochlorothiazide and captopril together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo).

You may also need to avoid taking hydrochlorothiazide and captopril with aliskiren if you have kidney disease.

To make sure hydrochlorothiazide and captopril is safe for you, tell your doctor if you have:

• kidney disease (or if you are on dialysis);
• cirrhosis or other liver disease;
• glaucoma;
• congestive heart failure;
• gout;
• lupus;
• diabetes; or
• an allergy to sulfa drugs or penicillin.

How should I take hydrochlorothiazide and captopril?

Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Your blood pressure will need to be checked often. Your blood and urine may also be tested if you have been vomiting or are dehydrated. Visit your doctor regularly.

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

If you need surgery, tell the surgeon ahead of time that you are using hydrochlorothiazide and captopril. You may need to stop using the medicine for a short time.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

What should I avoid while taking hydrochlorothiazide and captopril?

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Do not use potassium supplements or salt substitutes while you are taking hydrochlorothiazide and captopril, unless your doctor has told you to.

What are the possible side effects of hydrochlorothiazide and captopril?

• a light-headed feeling, like you might pass out;
• eye pain, vision problems;
• little or no urinating;
• chest pain, pounding heartbeats or fluttering in your chest;
• swelling, weight gain, shortness of breath;
• pale skin, easy bruising or bleeding;
• sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, trouble swallowing;
• high potassium --nausea, slow or unusual heart rate, weakness, loss of movement;
• low potassium --leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling;
• low levels of sodium --headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady; or
• severe skin reaction --fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

• cough;
• mild itching or rash;
• joint pain;
• numbness in your hands or feet;
• decreased sense of taste; or
• flushing (warmth, redness, or tingly feeling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect hydrochlorothiazide and captopril?

Tell your doctor about all your current medicines and any you start or stop using, especially:

• lithium; or
• other diuretics (water pills) or blood pressure medications.

This list is not complete. Other drugs may interact with hydrochlorothiazide and captopril, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

Your pharmacist can provide more information about hydrochlorothiazide and captopril.