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Home Knowledge Center Wellness Library hydroxyprogesterone injection

hydroxyprogesterone injection

Pronunciation: hye DROX ee pro JES te rone

Brand: Makena, Makena Auto-Injector

What is the most important information I should know about hydroxyprogesterone?

What is the most important information I should know about hydroxyprogesterone?

You should not use this medicine if you have: uncontrolled high blood pressure, unusual vaginal bleeding, liver disease or liver cancer, jaundice caused by your pregnancy, or if you have ever had circulation problems, a stroke or blood clot, or cancer of the breast, uterus/cervix, or vagina.

What is hydroxyprogesterone?

What is hydroxyprogesterone?

Hydroxyprogesterone is a form of progestin, a manmade form of a female hormone called progesterone.

Hydroxyprogesterone is used to lower the risk of premature birth in a woman who has already had one premature baby. Hydroxyprogesterone will not stop premature labor that has already begun.

Hydroxyprogesterone is not for use in women who are pregnant with more than one baby (twins, triplets, etc).

Hydroxyprogesterone may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving hydroxyprogesterone?

What should I discuss with my healthcare provider before receiving hydroxyprogesterone?

You should not be treated with this medicine if you are allergic to hydroxyprogesterone or castor oil, or if you have:

  • unusual vaginal bleeding that is not related to your pregnancy;
  • severe or uncontrolled high blood pressure;
  • liver disease or liver cancer;
  • jaundice caused by your pregnancy;
  • a history of cancer of the breast, uterus/cervix, or vagina; or
  • a history of a stroke, blood clot, or circulation problems.

Hydroxyprogesterone is not approved for use by anyone younger than 16 years old.

Tell your doctor if you have ever had:

  • eclampsia or preeclampsia of pregnancy;
  • kidney disease;
  • high blood pressure, heart disease;
  • migraine headaches;
  • diabetes (in you or a family member);
  • epilepsy or other seizure disorder;
  • asthma; or
  • depression.

It is not known whether hydroxyprogesterone will prevent any medical problems in a newborn baby. Talk to your doctor about your baby's individual risk.

How is hydroxyprogesterone given?

How is hydroxyprogesterone given?

Hydroxyprogesterone is injected under the skin or into a muscle.

A healthcare provider will give you this injection.

The first hydroxyprogesterone injection is usually given during the second trimester of pregnancy. The usual dosing schedule is one injection per week until the 37th week or until your baby is born. Follow your doctor's instructions.

Your doctor will need to check your progress on a regular basis. Do not miss any scheduled appointments. Every woman should remain under the care of a doctor during pregnancy.

What happens if I miss a dose?

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your hydroxyprogesterone injection.

What happens if I overdose?

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while receiving hydroxyprogesterone?

What should I avoid while receiving hydroxyprogesterone?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of hydroxyprogesterone?

What are the possible side effects of hydroxyprogesterone?

Get emergency medical help if you have signs of an allergic reaction: hives, itching; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • swelling, oozing, bleeding, or worsening pain where the injection was given;
  • jaundice (yellowing of the skin or eyes);
  • symptoms of depression (sleep problems, weakness, mood changes);
  • swelling in your hands, ankles, or feet;
  • increased blood pressure --severe headache, blurred vision, pounding in your neck or ears, anxiety, nosebleed; or
  • signs of a blood clot --sudden numbness or weakness, problems with vision or speech, swelling or redness in an arm or leg.

Common side effects may include:

  • pain, swelling, itching, rash, or a lump where the medicine was injected;
  • nausea; or
  • diarrhea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect hydroxyprogesterone?

What other drugs will affect hydroxyprogesterone?

Other drugs may affect hydroxyprogesterone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Where can I get more information?

Your doctor or pharmacist can provide more information about hydroxyprogesterone.

This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

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