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Home Knowledge Center Wellness Library leucovorin (oral)

leucovorin (oral)

Pronunciation: LOO koe VOR in

Leucovorin Calcium

slide 1 of 13, Leucovorin Calcium,

5 mg, round, white, imprinted with 54 293

Image of Leucovorin Calcium
slide 1 of 13

Leucovorin Calcium

slide 2 of 13, Leucovorin Calcium,

10 mg, round, white, imprinted with 54 942

Image of Leucovorin Calcium
slide 2 of 13

Leucovorin Calcium

slide 3 of 13, Leucovorin Calcium,

15 mg, round, yellow, imprinted with 54 650

Image of Leucovorin Calcium
slide 3 of 13

Leucovorin Calcium

slide 4 of 13, Leucovorin Calcium,

25 mg, round, yellow, imprinted with 54 013

Image of Leucovorin Calcium
slide 4 of 13

Leucovorin Calcium

slide 5 of 13, Leucovorin Calcium,

5 mg, round, white, imprinted with 54 293

Image of Leucovorin Calcium
slide 5 of 13

Leucovorin Calcium

slide 6 of 13, Leucovorin Calcium,

5 mg, round, white, imprinted with b, 484

Image of Leucovorin Calcium
slide 6 of 13

Leucovorin Calcium

slide 7 of 13, Leucovorin Calcium,

25 mg, round, green, imprinted with b, 485

Image of Leucovorin Calcium
slide 7 of 13

Leucovorin Calcium

slide 8 of 13, Leucovorin Calcium,

25 mg, round, green, imprinted with b, 485

Image of Leucovorin Calcium
slide 8 of 13

Leucovorin Calcium

slide 9 of 13, Leucovorin Calcium,

10 mg, round, white, imprinted with 54 942

Image of Leucovorin Calcium
slide 9 of 13

Leucovorin Calcium

slide 10 of 13, Leucovorin Calcium,

15 mg, round, yellow, imprinted with 54 650

Image of Leucovorin Calcium
slide 10 of 13

Leucovorin Calcium

slide 11 of 13, Leucovorin Calcium,

25 mg, round, green, imprinted with b, 485

Image of Leucovorin Calcium
slide 11 of 13

Leucovorin Calcium

slide 12 of 13, Leucovorin Calcium,

25 mg, round, yellow, imprinted with 54 013

Image of Leucovorin Calcium
slide 12 of 13

Leucovorin Calcium

slide 13 of 13, Leucovorin Calcium,

5 mg, round, white, imprinted with b, 484

Image of Leucovorin Calcium
slide 13 of 13
What is the most important information I should know about leucovorin?

What is the most important information I should know about leucovorin?

You should not take leucovorin if you have pernicious anemia or other types of anemia caused by a lack of vitamin B12.

What is leucovorin?

What is leucovorin?

Leucovorin is a form of folic acid. Folic acid helps your body produce and maintain new cells, and also helps prevent changes to DNA that may lead to cancer. Folic acid is present in many foods such as dried beans, peas, oranges, spinach, and others.

Leucovorin is used to reduce the side effects of large doses or accidental overdose of medications that can reduce the effects of folic acid in the body. This includes methotrexate (Rheumatrex), pyrimethamine (Daraprim), trimethoprim (Trimpex, Proloprim), and others.

Leucovorin may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking leucovorin?

What should I discuss with my healthcare provider before taking leucovorin?

You should not take leucovorin if you have pernicious anemia or other types of anemia caused by a lack of vitamin B12.

If possible before you receive leucovorin, tell your doctor if you have:

  • liver disease;
  • kidney disease;
  • breathing problems; or
  • if you are dehydrated.

Also tell your doctor about all other medications you currently use. There are many other drugs that can interact with methotrexate and slow down your body's ability to process and eliminate the drug. This can affect how quickly methotrexate is able to leave your body, even with the help of leucovorin.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether leucovorin passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I take leucovorin?

How should I take leucovorin?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

When treating an accidental overdose, leucovorin should be started as soon as possible for the best effect.

Leucovorin is usually given with other medications to help your kidneys remove methotrexate from your body. You may also be treated with IV fluids to keep you from getting dehydrated.

You will need frequent medical tests to help your doctor determine how long to treat you with leucovorin.

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

An overdose of leucovorin is not likely to cause life-threatening symptoms. However, leucovorin overdose can make other medications less effective.

What should I avoid while taking leucovorin?

What should I avoid while taking leucovorin?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of leucovorin?

What are the possible side effects of leucovorin?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect leucovorin?

What other drugs will affect leucovorin?

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • fluorouracil;
  • sulfamethoxazole and trimethoprim (Bactrim, Cotrim, SMZ-TMP or SMX-TMP); or
  • seizure medicine --phenobarbital, phenytoin, primidone.

This list is not complete. Other drugs may interact with leucovorin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

Where can I get more information?

Your pharmacist can provide more information about leucovorin.

This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

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