Skip to main navigation Skip to main content Skip to footer For Medicare For Providers For Brokers For Employers Español For Individuals & Families: For Individuals & Families Medical Dental Other Supplemental Explore coverage through work How to Buy Health Insurance Types of Dental Insurance Open Enrollment vs. Special Enrollment See all topics Shop for Medicare plans Member Guide Find a Doctor Log in to myCigna
Home Knowledge Center Wellness Library lisocabtagene maraleucel

lisocabtagene maraleucel

Pronunciation: LIS oh KAB ta jeen MAR a LOOsel

Brand: Breyanzi

What is the most important information I should know about lisocabtagene maraleucel?

What is the most important information I should know about lisocabtagene maraleucel?

A common but serious side effect of this medicine is called cytokine release syndrome, which causes fever, chills, trouble breathing, vomiting, and other symptoms. Your caregivers will have medication available to quickly treat this condition if it occurs.

What is lisocabtagene maraleucel?

What is lisocabtagene maraleucel?

Lisocabtagene maraleucel is an immunotherapy medicine used to treat large B-cell lymphoma in adults. Lisocabtagene maraleucel is given after at least two other cancer treatments did not work or have stopped working.

Lisocabtagene maraleucel is made using white blood cells removed from blood that is drawn from your body through a vein.

Lisocabtagene maraleucel may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving lisocabtagene maraleucel?

What should I discuss with my healthcare provider before receiving lisocabtagene maraleucel?

Tell your doctor if you have ever had:

  • hepatitis B or C; or
  • if you have received a vaccine within the past 6 weeks.

Using lisocabtagene maraleucel may increase your risk of developing other cancers. Ask your doctor about this risk.

Tell your doctor if you are pregnant or breastfeeding.

You may need to have a negative pregnancy test before starting this treatment.

How is lisocabtagene maraleucel given?

How is lisocabtagene maraleucel given?

Lisocabtagene maraleucel is available only at an authorized hospital or clinic, and must be given by specially trained healthcare professionals.

Lisocabtagene maraleucel is given after a procedure called leukapheresis (LOO-kuh-fuh-REE-sis).

During leukapheresis, some of your blood is collected through a small tube (catheter) placed into a vein. The catheter is connected to a machine that separates your white blood cells from other parts of the blood.

The cells are then sent to a laboratory where they are made into lisocabtagene maraleucel. Because it will take time to process your blood cells into lisocabtagene maraleucel, you will not receive the medicine on the same day your blood cells are drawn.

About 2 to 7 days before lisocabtagene maraleucel is given, you will be pre-treated with chemotherapy to help prepare your body for lisocabtagene maraleucel.

Once your body is ready to receive lisocabtagene maraleucel, your care providers will inject the medicine as an infusion into a vein.

You may be given other medications to help prevent serious side effects or an allergic reaction. Keep using these medicines for as long as your doctor has prescribed.

For at least 4 weeks, plan to stay near the hospital or clinic where you received lisocabtagene maraleucel.

Lisocabtagene maraleucel affects your immune system. You may get infections more easily, even serious or fatal infections.

If you've ever had hepatitis B, using lisocabtagene maraleucel can cause this virus to become active or get worse. You may need frequent liver function tests.

What happens if I miss a dose?

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your pre-treatment chemotherapy. The timing of your chemotherapy and lisocabtagene maraleucel injection is very important to the success of your treatment for lymphoma.

What happens if I overdose?

What happens if I overdose?

Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving lisocabtagene maraleucel?

What should I avoid after receiving lisocabtagene maraleucel?

This medicine can cause weakness, drowsiness, confusion, problems with memory or coordination, and seizures. Avoid driving or operating machinery for at least 8 weeks after you are treated with lisocabtagene maraleucel.

Do not donate blood, organs, tissues, or cells for transplantation.

What are the possible side effects of lisocabtagene maraleucel?

What are the possible side effects of lisocabtagene maraleucel?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

A common but serious side effect of this medicine is called cytokine release syndrome (CRS). Tell your caregivers right away if you have signs of this condition: fever, chills, dizziness, confusion, vomiting, diarrhea, fast heartbeats, trouble breathing, or feeling very weak or tired. Your caregivers will have medication available to quickly treat CRS if it occurs.

Call your doctor at once if you have:

  • problems with speech;
  • confusion, trouble concentrating, memory problems;
  • decreased consciousness;
  • tremors, or a seizure; or
  • signs of infection --fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Common side effects may include:

  • headache, dizziness;
  • confusion, problems with speech or thinking;
  • fever, chills, shaking;
  • nausea, vomiting, stomach pain;
  • diarrhea, constipation;
  • fast or irregular heartbeats;
  • cough, trouble breathing;
  • swelling; or
  • pain in your bones, joint, or muscles.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect lisocabtagene maraleucel?

What other drugs will affect lisocabtagene maraleucel?

Other drugs may affect lisocabtagene maraleucel, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Where can I get more information?

Your pharmacist can provide more information about lisocabtagene maraleucel.

This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

<cipublic-spinner variant="large"><span>Loading…</span></cipublic-spinner>

Page Footer

I want to...

Get an ID card File a claim View my claims and EOBs Check coverage under my plan See prescription drug list Find an in-network doctor, dentist, or facility Find a form Find 1095-B tax form information View the Cigna Glossary Contact Cigna

Audiences

Individuals and Families Medicare Employers Brokers Providers

Secure Member Sites

myCigna member portal Health Care Provider portal Cigna for Employers Client Resource Portal Cigna for Brokers

Cigna Company Information

About Cigna Company Profile Careers Newsroom Investors Suppliers Third Party Administrators International Evernorth

 Cigna. All rights reserved.

Privacy Legal Product Disclosures Cigna Company Names Customer Rights Accessibility Non-Discrimination Notice [PDF] Language Assistance [PDF] Report Fraud Sitemap

Disclaimer

Individual and family medical and dental insurance plans are insured by Cigna Health and Life Insurance Company (CHLIC), Cigna HealthCare of Arizona, Inc., Cigna HealthCare of Illinois, Inc., and Cigna HealthCare of North Carolina, Inc. Group health insurance and health benefit plans are insured or administered by CHLIC, Connecticut General Life Insurance Company (CGLIC), or their affiliates (see a listing of the legal entities  that insure or administer group HMO, dental HMO, and other products or services in your state). Accidental Injury, Critical Illness, and Hospital Care plans or insurance policies are distributed exclusively by or through operating subsidiaries of Cigna Corporation, are administered by Cigna Health and Life Insurance Company, and are insured by either (i) Cigna Health and Life Insurance Company (Bloomfield, CT); (ii) Life Insurance Company of North America (“LINA”) (Philadelphia, PA); or (iii) New York Life Group Insurance Company of NY (“NYLGICNY”) (New York, NY), formerly known as Cigna Life Insurance Company of New York. The Cigna name, logo, and other Cigna marks are owned by Cigna Intellectual Property, Inc. LINA and NYLGICNY are not affiliates of Cigna.

All insurance policies and group benefit plans contain exclusions and limitations. For availability, costs and complete details of coverage, contact a licensed agent or Cigna sales representative. This website is not intended for residents of New Mexico.

Selecting these links will take you away from Cigna.com to another website, which may be a non-Cigna website. Cigna may not control the content or links of non-Cigna websites. Details