Skip to main navigation Skip to main content Skip to footer For Medicare For Providers For Brokers For Employers Español For Individuals & Families: For Individuals & Families Medical Dental Other Supplemental Explore coverage through work How to Buy Health Insurance Types of Dental Insurance Open Enrollment vs. Special Enrollment See all topics Shop for Medicare plans Member Guide Find a Doctor Log in to myCigna
Home Knowledge Center Wellness Library luspatercept

luspatercept

Pronunciation: lus PAT er sept

Brand: Reblozyl

What is the most important information I should know about luspatercept?

What is the most important information I should know about luspatercept?

Before using luspatercept tell your doctor about all your medical conditions or allergies, all medicines you use, and if you are pregnant or breastfeeding.

What is luspatercept?

What is luspatercept?

Luspatercept is for use in adults with a blood disorder called beta thalassemia, in which the body does not produce enough hemoglobin (HEEM o glo bin). Hemoglobin carries oxygen through your blood to tissues and organs.

Luspatercept is used to treat anemia (lack of red blood cells) in adults with beta thalassemia who need to have regular red blood cell transfusions.

Luspatercept may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving luspatercept?

What should I discuss with my healthcare provider before receiving luspatercept?

Tell your doctor if you have ever had:

  • spleen removal surgery;
  • a stroke or blood clot;
  • high blood pressure;
  • high cholesterol;
  • diabetes;
  • if you smoke; or
  • if you use birth control pills or hormone replacement therapy.

Tell your doctor if you are pregnant or could become pregnant. Luspatercept may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 3 months after your last dose.

Do not breastfeed while using this medicine, and for at least 3 months after your last dose.

How is luspatercept given?

How is luspatercept given?

Luspatercept is injected under the skin, usually once every 3 weeks.

A healthcare provider will give you this injection.

Before each injection, your will need a blood test to check your hemoglobin levels. Be sure to tell your healthcare provider when you last had a blood transfusion.

Luspatercept doses are based on weight. Your dose needs may change if you gain or lose weight.

Your blood pressure will need to be checked often.

You may be given other medications to help control your blood pressure. Keep using this medicine for as long as your doctor has prescribed.

What happens if I miss a dose?

What happens if I miss a dose?

You should receive an injection as soon as you can, and then go back to your regular schedule. At least 3 weeks should pass between each injection.

What happens if I overdose?

What happens if I overdose?

Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving luspatercept?

What should I avoid while receiving luspatercept?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of luspatercept?

What are the possible side effects of luspatercept?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have:

  • severe headache, blurred vision, pounding in your neck or ears;
  • signs of a stroke --sudden numbness or weakness (especially on one side of the body), severe headache, slurred speech, balance problems;
  • signs of a blood clot in the lung --chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or
  • signs of a blood clot deep in the body --swelling, warmth, or redness in an arm or leg.

Your luspatercept injections may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

  • stomach pain, diarrhea;
  • headache, dizziness;
  • feeling tired;
  • cough; or
  • bone pain, joint pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect luspatercept?

What other drugs will affect luspatercept?

Other drugs may affect luspatercept, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Where can I get more information?

Your pharmacist can provide more information about luspatercept.

This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

<cipublic-spinner variant="large"><span>Loading…</span></cipublic-spinner>

Page Footer

I want to...

Get an ID card File a claim View my claims and EOBs Check coverage under my plan See prescription drug list Find an in-network doctor, dentist, or facility Find a form Find 1095-B tax form information View the Cigna Glossary Contact Cigna

Audiences

Individuals and Families Medicare Employers Brokers Providers

Secure Member Sites

myCigna member portal Health Care Provider portal Cigna for Employers Client Resource Portal Cigna for Brokers

Cigna Company Information

About Cigna Company Profile Careers Newsroom Investors Suppliers Third Party Administrators International Evernorth

 Cigna. All rights reserved.

Privacy Legal Product Disclosures Cigna Company Names Customer Rights Accessibility Non-Discrimination Notice [PDF] Language Assistance [PDF] Report Fraud Sitemap

Disclaimer

Individual and family medical and dental insurance plans are insured by Cigna Health and Life Insurance Company (CHLIC), Cigna HealthCare of Arizona, Inc., Cigna HealthCare of Illinois, Inc., and Cigna HealthCare of North Carolina, Inc. Group health insurance and health benefit plans are insured or administered by CHLIC, Connecticut General Life Insurance Company (CGLIC), or their affiliates (see a listing of the legal entities  that insure or administer group HMO, dental HMO, and other products or services in your state). Accidental Injury, Critical Illness, and Hospital Care plans or insurance policies are distributed exclusively by or through operating subsidiaries of Cigna Corporation, are administered by Cigna Health and Life Insurance Company, and are insured by either (i) Cigna Health and Life Insurance Company (Bloomfield, CT); (ii) Life Insurance Company of North America (“LINA”) (Philadelphia, PA); or (iii) New York Life Group Insurance Company of NY (“NYLGICNY”) (New York, NY), formerly known as Cigna Life Insurance Company of New York. The Cigna name, logo, and other Cigna marks are owned by Cigna Intellectual Property, Inc. LINA and NYLGICNY are not affiliates of Cigna.

All insurance policies and group benefit plans contain exclusions and limitations. For availability, costs and complete details of coverage, contact a licensed agent or Cigna sales representative. This website is not intended for residents of New Mexico.

Selecting these links will take you away from Cigna.com to another website, which may be a non-Cigna website. Cigna may not control the content or links of non-Cigna websites. Details