lutetium Lu 177 dotatate

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lutetium Lu 177 dotatate

Pronunciation: loo TEE shee um LOO 177 DOE ta tate

Brand: Lutathera

What is the most important information I should know about lutetium Lu 177 dotatate?

Do not become pregnant or breast-feed a baby while receiving lutetium Lu 177 dotatate.

Both men and women using this medicine should use effective birth control to prevent pregnancy. Lutetium Lu 177 dotatate can harm an unborn baby or cause birth defects if the mother or father is using this medicine.

What is lutetium Lu 177 dotatate?

Lutetium Lu 177 dotatate is a radioactive medicine that binds itself to a specific part of certain tumor cells, allowing the radiation to enter and destroy those cells.

Lutetium Lu 177 dotatate is used to treat certain cancers of the digestive tract, including the stomach, pancreas, and intestines.

Lutetium Lu 177 dotatate may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving lutetium Lu 177 dotatate?

You should not use lutetium Lu 177 dotatate if you are pregnant or breast-feeding.

Lutetium Lu 177 dotatate can harm an unborn baby or cause birth defects if the mother or the father is receiving this medicine.

If you are a woman, use effective birth control to prevent pregnancy while you are receiving this medicine and for at least 7 months after your last dose.
If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 4 months after your last dose.
Tell your doctor right away if a pregnancy occurs while either the mother or the father is receiving lutetium Lu 177 dotatate.

Do not breast-feed while receiving lutetium Lu 177 dotatate, and for at least 4 months after your last dose.

Tell your doctor if you have ever had:

kidney disease;
liver disease;
diabetes;
high blood pressure; or
any type of radiation treatment.

Lutetium Lu 177 dotatate may cause other types of cancer, such as leukemia. Ask your doctor about this risk.

This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because lutetium Lu 177 dotatate may harm the baby if a pregnancy does occur.

How is lutetium Lu 177 dotatate given?

Lutetium Lu 177 dotatate is given as an infusion into a vein. A healthcare provider will give you this injection once every 8 weeks for a total of 4 doses.

This medicine must be given slowly, and the infusion can take 30 to 40 minutes to complete.

After each infusion, you will be given another medicine called octreotide, which is injected into a muscle. Octreotide injections are usually given once every 4 weeks for up to 18 months.

You may be given other medications to help prevent serious side effects or allergic reaction. Keep using these medicines for as long as your doctor has prescribed.

Drink plenty of fluids while being treated with this medicine. You should urinate often, to help keep your kidneys working properly.

You will need frequent medical tests to be sure this medicine is not causing harmful effects. Your cancer treatments may be delayed based on the results.

For up to 30 days after you are treated with lutetium Lu 177 dotatate, your urine will contain radiation. To prevent the spread of this radiation, use a toilet rather than a urinal, and sit on the toilet while urinating.

Always wash your hands after using the bathroom. Avoid handling any clean-up of your stools or urine without wearing latex rubber gloves. If another person is handling your urine, they should wear gloves, eye protection, and a mask to cover the nose and mouth.

When cleaning any spills of bodily fluid, use only disposable cleaning cloths that can be flushed down a toilet. Ask your doctor or health department how to dispose of any bodily fluid spills that cannot be flushed down a toilet.

Wash any soiled clothing separately from the laundry of other people in your home.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your lutetium Lu 177 dotatate injection.

What happens if I overdose?

Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving lutetium Lu 177 dotatate?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of lutetium Lu 177 dotatate?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

little or no urination;
flushing (warmth, redness, or tingly feeling);
diarrhea;
a light-headed feeling, like you might pass out;
wheezing, chest tightness, trouble breathing;
low blood cell counts --fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath; or
low potassium level --leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

nausea, vomiting;
high blood sugar;
low potassium; or
abnormal liver function tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect lutetium Lu 177 dotatate?

Other drugs may affect lutetium Lu 177 dotatate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about lutetium Lu 177 dotatate.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2023 Cerner Multum, Inc. Version: 1.01. Revision date: 5/10/2018.

Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by End-User License Agreement, which can be accessed by clicking on this link.

This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

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lutetium Lu 177 dotatate

What is the most important information I should know about lutetium Lu 177 dotatate?

What is lutetium Lu 177 dotatate?

What should I discuss with my healthcare provider before receiving lutetium Lu 177 dotatate?

How is lutetium Lu 177 dotatate given?

What happens if I miss a dose?

What happens if I overdose?

What should I avoid while receiving lutetium Lu 177 dotatate?

What are the possible side effects of lutetium Lu 177 dotatate?

What other drugs will affect lutetium Lu 177 dotatate?

Where can I get more information?

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