What should I discuss with my healthcare provider before taking naproxen and sumatriptan?
You should not use this medicine if you are allergic to naproxen (Aleve, Anaprox, Naprosyn) or sumatriptan (Imitrex), or if you have:
- heart problems, uncontrolled high blood pressure;
- a history of heart attack or stroke (including TIA or "mini-stroke");
- Wolff-Parkinson-White Syndrome (sudden fast heartbeats) or other heart rhythm disorder;
- blood circulation problems (including poor blood flow to your arms and legs, stomach, intestines, or kidneys);
- a history of asthma or severe allergic reaction after taking aspirin or an NSAID; or
- severe liver disease.
Naproxen can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Naproxen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using naproxen and sumatriptan, especially in older adults.
Do not use naproxen and sumatriptan if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
Do not take naproxen and sumatriptan within 24 hours before or after using another migraine headache medicine, including:
- sumatriptan tablets, injection, or nasal spray;
- almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, or zolmitriptan; or
- ergot medicine such as ergotamine, dihydroergotamine, or methylergonovine.
Tell your doctor if you have ever had:
- heart problems or a stroke (in you or a family member);
- high blood pressure, high cholesterol, diabetes, or if you smoke;
- epilepsy or other seizure disorder; or
- liver or kidney disease.
If you are pregnant, you should not take naproxen unless your doctor tells you to. Taking an NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy.
You should not breastfeed while you are taking this medicine.
Naproxen and sumatriptan is not approved for use by anyone younger than 12 years old.