Skip to main navigation Skip to main content Skip to footer For Medicare For Providers For Brokers For Employers Español For Individuals & Families: For Individuals & Families Medical Dental Other Supplemental Explore coverage through work How to Buy Health Insurance Types of Dental Insurance Open Enrollment vs. Special Enrollment See all topics Shop for Medicare plans Member Guide Find a Doctor Log in to myCigna
Home Knowledge Center Wellness Library pegvaliase


Pronunciation: peg VAL i ase

Brand: Palynziq

What is the most important information I should know about pegvaliase?

What is the most important information I should know about pegvaliase?

Pegvaliase can cause a serious allergic reaction. Your first dose will be given in a medical setting.

Get emergency medical help if you have signs of an allergic reaction such as hives, itching, dizziness, wheezing, trouble breathing, or swelling in your face or throat. Your doctor may prescribe an epinephrine injection kit to keep with you at all times.

What is pegvaliase?

What is pegvaliase?

Pegvaliase is used to lower phenylalanine blood levels in adults with phenylketonuria (PKU) not controlled with other treatment.

Pegvaliase is available only from a certified pharmacy under a special program.

Pegvaliase may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using pegvaliase?

What should I discuss with my healthcare provider before using pegvaliase?

Pegvaliase can cause a serious allergic reaction. Your doctor may prescribe an epinephrine injection kit to use in case you have a severe allergic reaction. Keep this injection kit with you at all times.

Tell your doctor if you think you might be unable to give yourself an emergency epinephrine injection.

Follow your doctor's instructions about using this medicine if you are pregnant. Controlling your phenylalanine levels is very important during pregnancy. Your name may be listed on a pregnancy registry to track the effects of pegvaliase on the baby.

Ask a doctor if it is safe to breastfeed while using this medicine.

Not approved for use by anyone younger than 18 years old.

How should I use pegvaliase?

How should I use pegvaliase?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Pegvaliase is injected under the skin. You may be given other medications to help prevent serious side effects or an allergic reaction.

You will receive your first dose in a medical setting to make sure you do not have an allergic reaction.

Read and follow all Instructions for Use. Ask your doctor or pharmacist if you need help.

Prepare an injection only when you are ready to give it. Call your pharmacist if the medicine looks cloudy, has changed colors, or has particles in it.

Do not shake the prefilled syringe or you may ruin the medicine.

Your healthcare provider will show you where to inject pegvaliase. Do not inject into the same place two times in a row.

You may need to have someone with you for at least 1 hour after you inject this medicine at home, to watch you for signs of an allergic reaction and give the epinephrine injection if needed.

Read the Warning Card about allergic reactions and learn what symptoms to watch for. Keep the card with you at all times.

You will need frequent medical tests.

You will need to follow a special diet. Follow all instructions of your doctor or dietitian. Learn about the foods you should eat or avoid.

Store this medicine in the refrigerator, do not freeze.

You may store the medicine for up to 30 days at room temperature in its original container, protected from light. Do not put the medicine back into the refrigerator. Throw away any unused medicine after 30 days or after the expiration date on the label has passed.

Throw away a prefilled syringe after one use, even if there is still medicine left inside.

Do not reuse a needle or syringe. Place them in a puncture-proof "sharps" container and dispose of it following state or local laws. Keep out of the reach of children and pets.

What happens if I miss a dose?

What happens if I miss a dose?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

What happens if I overdose?

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using pegvaliase?

What should I avoid while using pegvaliase?

Avoid injecting into skin that is red, bruised, hard, tender, injured, or irritated. Do not inject this medicine into skin areas with moles, scars, birthmarks, or tattoos.

What are the possible side effects of pegvaliase?

What are the possible side effects of pegvaliase?

Stop the pegvaliase injection and get emergency medical help if you have signs of an allergic reaction:

  • hives, rash, itching;
  • confusion, dizziness, feeling like you might pass out;
  • nausea, vomiting, diarrhea;
  • loss of bladder or bowel control;
  • fast heartbeats;
  • wheezing, chest tightness, difficult breathing;
  • flushing (warmth, redness, or tingly feeling); or
  • swelling of your face, lips, tongue, or throat.

Common side effects may include:

  • cough, stuffy nose;
  • mouth and throat pain;
  • dizziness;
  • anxiety;
  • low phenylalanine blood levels;
  • a spreading skin reaction (itching, redness, rash) that could last at least 14 days;
  • headache, joint pain;
  • nausea, vomiting, stomach pain, diarrhea;
  • tiredness; or
  • pain, tenderness, bruising, redness, itching, or swelling where the injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect pegvaliase?

What other drugs will affect pegvaliase?

Other drugs may affect pegvaliase, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Where can I get more information?

Where can I get more information?

Your pharmacist can provide more information about pegvaliase.

This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

<cipublic-spinner variant="large"><span>Loading…</span></cipublic-spinner>

Page Footer

I want to...

Get an ID card File a claim View my claims and EOBs Check coverage under my plan See prescription drug list Find an in-network doctor, dentist, or facility Find a form Find 1095-B tax form information View the Cigna Glossary Contact Cigna


Individuals and Families Medicare Employers Brokers Providers

Secure Member Sites

myCigna member portal Health Care Provider portal Cigna for Employers Client Resource Portal Cigna for Brokers

The Cigna Group Information

About The Cigna Group Company Profile Careers Newsroom Investors Suppliers The Cigna Group Third Party Administrators International Evernorth

 Cigna. All rights reserved.

Privacy Legal Product Disclosures Cigna Company Names Customer Rights Accessibility Non-Discrimination Notice Language Assistance [PDF] Report Fraud Sitemap


Individual and family medical and dental insurance plans are insured by Cigna Health and Life Insurance Company (CHLIC), Cigna HealthCare of Arizona, Inc., Cigna HealthCare of Illinois, Inc., Cigna HealthCare of Georgia, Inc., Cigna HealthCare of North Carolina, Inc., Cigna HealthCare of South Carolina, Inc., and Cigna HealthCare of Texas, Inc. Group health insurance and health benefit plans are insured or administered by CHLIC, Connecticut General Life Insurance Company (CGLIC), or their affiliates (see a listing of the legal entities that insure or administer group HMO, dental HMO, and other products or services in your state). Accidental Injury, Critical Illness, and Hospital Care plans or insurance policies are distributed exclusively by or through operating subsidiaries of Cigna Corporation, are administered by Cigna Health and Life Insurance Company, and are insured by either (i) Cigna Health and Life Insurance Company (Bloomfield, CT); (ii) Life Insurance Company of North America (“LINA”) (Philadelphia, PA); or (iii) New York Life Group Insurance Company of NY (“NYLGICNY”) (New York, NY), formerly known as Cigna Life Insurance Company of New York. The Cigna name, logo, and other Cigna marks are owned by Cigna Intellectual Property, Inc. LINA and NYLGICNY are not affiliates of Cigna.

All insurance policies and group benefit plans contain exclusions and limitations. For availability, costs and complete details of coverage, contact a licensed agent or Cigna sales representative. This website is not intended for residents of New Mexico.

Selecting these links will take you away from to another website, which may be a non-Cigna website. Cigna may not control the content or links of non-Cigna websites. Details