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Home Knowledge Center Wellness Library phenylephrine and promethazine

phenylephrine and promethazine

Pronunciation: fen ill EFF rin and pro MEH thah zeen

Brand: Phenergan VC, Promethazine VC Plain

What is the most important information I should know about phenylephrine and promethazine?

What is the most important information I should know about phenylephrine and promethazine?

Do not give this medicine to a child younger than 2 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

What is phenylephrine and promethazine?

What is phenylephrine and promethazine?

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Promethazine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Phenylephrine and promethazine is a combination medicine used to treat sneezing, runny nose, watery eyes, hives, skin rash, itching, and other cold or allergy symptoms.

Phenylephrine and promethazine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking phenylephrine and promethazine?

What should I discuss with my healthcare provider before taking phenylephrine and promethazine?

You should not use this medicine if you are allergic to phenylephrine or promethazine, or if you have:

  • asthma or COPD;
  • high blood pressure; or
  • coronary artery disease.

Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

To make sure phenylephrine and promethazine is safe for you, tell your doctor if you have:

  • sleep apnea (breathing stops during sleep);
  • heart disease;
  • severe constipation, a blockage in your stomach or intestines;
  • diabetes;
  • glaucoma;
  • a thyroid disorder;
  • liver or kidney disease;
  • epilepsy or other seizure disorder;
  • enlarged prostate or urination problems;
  • pheochromocytoma (an adrenal gland tumor); or
  • a weak immune system.

FDA pregnancy category C. It is not known whether phenylephrine and promethazine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

It is not known whether phenylephrine and promethazine passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Artificially sweetened liquid medicine may contain phenylalanine. Check the medication label if you have phenylketonuria (PKU).

How should I take phenylephrine and promethazine?

How should I take phenylephrine and promethazine?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. This medicine is usually taken only for a short time until your symptoms clear up.

Do not give this medicine to a child younger than 2 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Do not take for longer than 7 days in a row. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache or skin rash.

If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken this medicine within the past few days.

Store at room temperature away from moisture and heat. Do not freeze.

What happens if I miss a dose?

What happens if I miss a dose?

Since this medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking phenylephrine and promethazine?

What should I avoid while taking phenylephrine and promethazine?

This medicine may cause blurred vision or impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Drinking alcohol can increase certain side effects of promethazine.

Ask a doctor or pharmacist before using any other cold, cough, allergy, or sleep medicine. Antihistamines and decongestants are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine or decongestant.

What are the possible side effects of phenylephrine and promethazine?

What are the possible side effects of phenylephrine and promethazine?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • seizure (convulsions);
  • weak or shallow breathing;
  • jaundice (yellowing of the skin or eyes);
  • confusion, hallucinations;
  • sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing;
  • uncontrollable movements of your eyes, lips, tongue, face, arms, or legs; or
  • severe nervous system reaction --very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Common side effects may include:

  • dizziness, drowsiness;
  • dry mouth, nose, or throat;
  • blurred vision; or
  • constipation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect phenylephrine and promethazine?

What other drugs will affect phenylephrine and promethazine?

Ask a doctor or pharmacist before using this medicine if you are also using any other drugs, including prescription and over-the-counter medicines, vitamins, and herbal products. Some medicines can cause unwanted or dangerous effects when used together. Not all possible interactions are listed in this medication guide.

Taking this medicine with other drugs that make you sleepy or slow your breathing can worsen these effects. Ask your doctor before taking phenylephrine and promethazine with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Where can I get more information?

Where can I get more information?

Your pharmacist can provide more information about phenylephrine and promethazine.

This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

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