Skip to main navigation Skip to main content Skip to footer For Medicare For Providers For Brokers For Employers Español For Individuals & Families: For Individuals & Families Medical Dental Other Supplemental Explore coverage through work How to Buy Health Insurance Types of Dental Insurance Open Enrollment vs. Special Enrollment See all topics Shop for Medicare plans Member Guide Find a Doctor Log in to myCigna
Home Knowledge Center Wellness Library ranolazine

ranolazine

Pronunciation: ra NOE la zeen

Brand: Ranexa

Ranexa

slide 1 of 3, Ranexa,

500 mg, oval, orange, imprinted with GSI500

Image of Ranexa
slide 1 of 3

Ranexa

slide 2 of 3, Ranexa,

1000 mg, oval, yellow, imprinted with GSI 1000

Image of Ranexa
slide 2 of 3

Ranexa

slide 3 of 3, Ranexa,

500 mg, oval, yellow, imprinted with CVT500

Image of Ranexa
slide 3 of 3
What is the most important information I should know about ranolazine?

What is the most important information I should know about ranolazine?

You should not take ranolazine if you have cirrhosis of the liver.

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

What is ranolazine?

What is ranolazine?

Ranolazine is used to treat chronic angina (chest pain). Ranolazine is not for use during an acute (emergency) attack of angina.

Ranolazine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking ranolazine?

What should I discuss with my healthcare provider before taking ranolazine?

You should not take ranolazine if you are allergic to it, or if you have:

  • cirrhosis of the liver.

Many drugs can interact and cause dangerous effects. Some drugs should not be used together with ranolazine. Your doctor may change your treatment plan if you also use:

  • clarithromycin;
  • nefazodone;
  • St. John's wort;
  • antifungal medicine --itraconazole, ketoconazole;
  • HIV or AIDS medicine --indinavir, lopinavir/ritonavir, nelfinavir, ritonavir, saquinavir;
  • seizure medicine --carbamazepine, phenobarbital, phenytoin; or
  • tuberculosis medicine --rifabutin, rifampin, rifapentine.

Tell your doctor if you have ever had:

  • long QT syndrome (in you or a family member);
  • liver disease; or
  • kidney disease.

Tell your doctor if you are pregnant or breastfeeding.

How should I take ranolazine?

How should I take ranolazine?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may take ranolazine with or without food.

Swallow the tablet whole and do not crush, chew, or break it.

Chronic angina is often treated with a combination of drugs. Use all medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice.

Call your doctor if your symptoms do not improve, or if they get worse.

You will need frequent medical tests to check your heart and kidney function.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

What happens if I miss a dose?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

What happens if I overdose?

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose can cause nausea, vomiting, numbness or tingling, dizziness, double vision, confusion, or fainting.

What should I avoid while taking ranolazine?

What should I avoid while taking ranolazine?

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Grapefruit may interact with ranolazine and lead to unwanted side effects. Avoid the use of grapefruit products.

What are the possible side effects of ranolazine?

What are the possible side effects of ranolazine?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • fast or pounding heartbeats, fluttering in your chest; or
  • kidney problems --little or no urination, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath.

Common side effects may include:

  • nausea, constipation;
  • headache; or
  • dizziness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect ranolazine?

What other drugs will affect ranolazine?

Tell your doctor about all your current medicines. Many drugs can affect ranolazine, especially:

  • any other medicine to treat heart disease;
  • an antibiotic or antifungal medicine;
  • cholesterol-lowering medicine;
  • oral diabetes medicine;
  • medicine to prevent organ transplant rejection;
  • medicine to treat a mental illness; or
  • medicine to treat or prevent nausea and vomiting caused by chemotherapy or radiation.

This list is not complete and many other drugs may affect ranolazine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Where can I get more information?

Your pharmacist can provide more information about ranolazine.

This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

<cipublic-spinner variant="large"><span>Loading…</span></cipublic-spinner>

Page Footer

I want to...

Get an ID card File a claim View my claims and EOBs Check coverage under my plan See prescription drug list Find an in-network doctor, dentist, or facility Find a form Find 1095-B tax form information View the Cigna Glossary Contact Cigna

Audiences

Individuals and Families Medicare Employers Brokers Providers

Secure Member Sites

myCigna member portal Health Care Provider portal Cigna for Employers Client Resource Portal Cigna for Brokers

Cigna Company Information

About Cigna Company Profile Careers Newsroom Investors Suppliers Third Party Administrators International Evernorth

 Cigna. All rights reserved.

Privacy Legal Product Disclosures Cigna Company Names Customer Rights Accessibility Non-Discrimination Notice [PDF] Language Assistance [PDF] Report Fraud Sitemap

Disclaimer

Individual and family medical and dental insurance plans are insured by Cigna Health and Life Insurance Company (CHLIC), Cigna HealthCare of Arizona, Inc., Cigna HealthCare of Illinois, Inc., and Cigna HealthCare of North Carolina, Inc. Group health insurance and health benefit plans are insured or administered by CHLIC, Connecticut General Life Insurance Company (CGLIC), or their affiliates (see a listing of the legal entities  that insure or administer group HMO, dental HMO, and other products or services in your state). Accidental Injury, Critical Illness, and Hospital Care plans or insurance policies are distributed exclusively by or through operating subsidiaries of Cigna Corporation, are administered by Cigna Health and Life Insurance Company, and are insured by either (i) Cigna Health and Life Insurance Company (Bloomfield, CT); (ii) Life Insurance Company of North America (“LINA”) (Philadelphia, PA); or (iii) New York Life Group Insurance Company of NY (“NYLGICNY”) (New York, NY), formerly known as Cigna Life Insurance Company of New York. The Cigna name, logo, and other Cigna marks are owned by Cigna Intellectual Property, Inc. LINA and NYLGICNY are not affiliates of Cigna.

All insurance policies and group benefit plans contain exclusions and limitations. For availability, costs and complete details of coverage, contact a licensed agent or Cigna sales representative. This website is not intended for residents of New Mexico.

Selecting these links will take you away from Cigna.com to another website, which may be a non-Cigna website. Cigna may not control the content or links of non-Cigna websites. Details