Skip to main navigation Skip to main content Skip to footer For Medicare For Providers For Brokers For Employers Español For Individuals & Families: For Individuals & Families Medical Dental Other Supplemental Explore coverage through work How to Buy Health Insurance Types of Dental Insurance Open Enrollment vs. Special Enrollment See all topics Shop for Medicare plans Member Guide Find a Doctor Log in to myCigna
Home Knowledge Center Wellness Library satralizumab

satralizumab

Pronunciation: SAT ra LIZ ue mab

Brand: Enspryng

What is the most important information I should know about satralizumab?

What is the most important information I should know about satralizumab?

Satralizumab affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have signs of infection (fever, chills, cough, tiredness, muscle pain, diarrhea, stomach cramps, increased urination, burning when you urinate, skin sores or redness, swelling or tenderness).

What is satralizumab?

What is satralizumab?

Satralizumab is used to treat adults with neuromyelitis optica spectrum disorder (NMOSD). NMOSD is a rare, chronic autoimmune disease that causes inflammation in the central nervous system. This can lead to damage of the optic nerves, spinal cord, and/or brain.

Satralizumab is used only if your body produces antibodies to a protein called aquaporin-4 (AQP4). Your doctor will test you for this antibody.

Satralizumab may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using satralizumab?

What should I discuss with my healthcare provider before using satralizumab?

You should not use satralizumab if you are allergic to it, or if you have an active infection such as:

  • hepatitis B; or
  • tuberculosis.

Tell your doctor if you have ever had tuberculosis, if anyone in your household has tuberculosis, or if you have recently traveled to an area where tuberculosis is common.

Tell your doctor if you have ever had:

  • an active or chronic infection;
  • liver problems, hepatitis B (or if you are a carrier of hepatitis B); or
  • if you have recently received or are scheduled to receive a vaccine.

Make sure you are current on all vaccines before you begin treatment with satralizumab.

You should not receive a "live" vaccine for at least 4 weeks before using satralizumab. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

You should not receive a "non-live" (sometimes called inactivated) vaccine for at least 2 weeks before using satralizumab. Non-live vaccines include the flu (influenza) shot and injected vaccines for hepatitis A, polio, or rabies.

Tell your doctor if you are pregnant or breastfeeding.

If you use satralizumab while you are pregnant, make sure any doctor caring for your new baby knows that you used this medicine during pregnancy. Being exposed to satralizumab in the womb could affect your baby's vaccination schedule.

How should I use satralizumab?

How should I use satralizumab?

Your doctor may perform tests to make sure you do not have conditions that would prevent you from safely using satralizumab.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Satralizumab is injected under the skin. A healthcare provider may teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.

Prepare an injection only when you are ready to give it. Do not shake the prefilled syringe. Do not use if the syringe is damaged or if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.

Satralizumab is given in 3 loading doses once every 2 weeks, followed by maintenance doses given once every 4 weeks. Your doctor will determine how long to treat you with this medicine.

Inject all of the medicine in the prefilled syringe. Tell your doctor if you don't receive the full dose.

Your healthcare provider will show you where on your body to inject satralizumab. Use a different place each time you give an injection. Do not inject into the same place two times in a row.

You will need frequent medical tests.

Call your doctor if you have any signs of infection (fever, chills, cough, sore throat). Do not inject this medicine while you are having signs of an active infection.

If you stop using satralizumab for a short time, you may need to restart the medicine using loading doses once every 2 weeks. Follow your doctor's instructions very carefully.

Store in the refrigerator. Protect from light and do not freeze.

Take the medicine out of the refrigerator and let it reach room temperature for 30 minutes before injecting your dose. Do not leave the medicine out of a refrigerator for longer than 8 days. Do not warm the medicine, and protect it from high heat.

Each prefilled syringe is for one use only. Throw it away after one use, even if there is still medicine left inside.

What happens if I miss a dose?

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose.

If you have stopped treatment for a side effect or infection, carefully follow your doctor's instructions about the schedule for restarting the medicine.

What happens if I overdose?

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking satralizumab?

What should I avoid while taking satralizumab?

Do not inject this medicine into scars, moles, broken skin, or skin that is red, bruised, tender, or hard.

Do not receive any vaccine while using satralizumab.

What are the possible side effects of satralizumab?

What are the possible side effects of satralizumab?

Stop using this medicine and get emergency medical help if you have signs of an allergic reaction: hives; feeling light-headed; stomach pain, vomiting; difficult breathing; swelling of your face, lips, tongue, or throat.

You may get infections more easily, even serious or fatal infections. Call your doctor right away if you have signs of infection such as:

  • fever, chills, night sweats;
  • sore throat. ongoing cough, feeling very tired;
  • muscle pain;
  • diarrhea, stomach cramps;
  • loss of appetite, weight loss;
  • increased urination, burning when you urinate; or
  • skin sores, redness, swelling or tenderness.

Common side effects may include:

  • headache, joint pain;
  • nausea, stomach pain;
  • feeling tired;
  • pain in your arms, hands, legs, or feet;
  • rash; or
  • cold symptoms such as stuffy nose, runny nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect satralizumab?

What other drugs will affect satralizumab?

Other drugs may affect satralizumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Where can I get more information?

Your pharmacist can provide more information about satralizumab.

This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

<cipublic-spinner variant="large"><span>Loading…</span></cipublic-spinner>

Page Footer

I want to...

Get an ID card File a claim View my claims and EOBs Check coverage under my plan See prescription drug list Find an in-network doctor, dentist, or facility Find a form Find 1095-B tax form information View the Cigna Glossary Contact Cigna

Audiences

Individuals and Families Medicare Employers Brokers Providers

Secure Member Sites

myCigna member portal Health Care Provider portal Cigna for Employers Client Resource Portal Cigna for Brokers

Cigna Company Information

About Cigna Company Profile Careers Newsroom Investors Suppliers Third Party Administrators International Evernorth

 Cigna. All rights reserved.

Privacy Legal Product Disclosures Cigna Company Names Customer Rights Accessibility Non-Discrimination Notice [PDF] Language Assistance [PDF] Report Fraud Sitemap

Disclaimer

Individual and family medical and dental insurance plans are insured by Cigna Health and Life Insurance Company (CHLIC), Cigna HealthCare of Arizona, Inc., Cigna HealthCare of Illinois, Inc., and Cigna HealthCare of North Carolina, Inc. Group health insurance and health benefit plans are insured or administered by CHLIC, Connecticut General Life Insurance Company (CGLIC), or their affiliates (see a listing of the legal entities  that insure or administer group HMO, dental HMO, and other products or services in your state). Accidental Injury, Critical Illness, and Hospital Care plans or insurance policies are distributed exclusively by or through operating subsidiaries of Cigna Corporation, are administered by Cigna Health and Life Insurance Company, and are insured by either (i) Cigna Health and Life Insurance Company (Bloomfield, CT); (ii) Life Insurance Company of North America (“LINA”) (Philadelphia, PA); or (iii) New York Life Group Insurance Company of NY (“NYLGICNY”) (New York, NY), formerly known as Cigna Life Insurance Company of New York. The Cigna name, logo, and other Cigna marks are owned by Cigna Intellectual Property, Inc. LINA and NYLGICNY are not affiliates of Cigna.

All insurance policies and group benefit plans contain exclusions and limitations. For availability, costs and complete details of coverage, contact a licensed agent or Cigna sales representative. This website is not intended for residents of New Mexico.

Selecting these links will take you away from Cigna.com to another website, which may be a non-Cigna website. Cigna may not control the content or links of non-Cigna websites. Details