thalidomide

What is the most important information I should know about thalidomide?

Both men and women using this medicine should use effective birth control to prevent pregnancy during treatment, and for up to 4 weeks after your last dose.

What is thalidomide?

Thalidomide is used together with dexamethasone to treat multiple myeloma (bone marrow cancer). Thalidomide is also used to treat and prevent moderate to severe skin lesions caused by leprosy.

Thalidomide is available only in a 28-day supply from a certified pharmacy under a special program. You must be registered in the program and agree to use birth control as required.

Thalidomide may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking thalidomide?

For Women: If you have not had a hysterectomy, you will be required to use two reliable forms of birth control beginning 4 weeks before you start taking thalidomide and ending 4 weeks after you stop taking it. Even women with fertility problems are required to use birth control while taking thalidomide. You must also have a negative pregnancy test at 10 to 14 days before treatment and again at 24 hours before. While you are taking thalidomide, you will have a pregnancy test every 2 to 4 weeks.

Your birth control method must be proven highly effective, such as birth control pills, an intrauterine device (IUD), a tubal ligation, or a sexual partner's vasectomy. The extra form of birth control you use must be a barrier method such as a condom, diaphragm, cervical cap, or contraceptive sponge.

For Men: Use a condom to prevent pregnancy during your treatment, and for up to 4 weeks after you stop taking it. You must always use latex condoms when having sex with a woman who is able to get pregnant, even if you have had a vasectomy. Call your doctor if you have had unprotected sex, even once, or if you think your female sexual partner may be pregnant.

Treatment with thalidomide may increase your risk of a blood clot or stroke during treatment for multiple myeloma. Ask your doctor about your specific risk.

Tell your doctor if you have ever had:

• heart disease, a stroke, or a blood clot;
• a seizure;
• if you need surgery; or
• if you also use pembrolizumab (Keytruda).

How should I take thalidomide?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Never share this medicine with another person.

Take thalidomide on an empty stomach, at least 1 hour after eating a meal. Swallow the capsule whole.

Your doctor will need to check your progress on a regular basis.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

What should I avoid while taking thalidomide?

What are the possible side effects of thalidomide?

• numbness, tingling, or burning pain in your hands or feet;
• slow heartbeats, shallow breathing, severe drowsiness, feeling like you might pass out;
• severe or ongoing constipation;
• a seizure (convulsions);
• signs of bleeding --easy bruising, nosebleeds, bleeding gums, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
• signs of a stroke or blood clot --sudden numbness or weakness, problems with vision or speech, chest pain, shortness of breath, swelling or redness in an arm or leg;
• heart attack symptoms --chest pain spreading to your jaw or shoulder, nausea, sweating;
• low blood cell counts --fever, chills, flu-like symptoms, swollen gums, mouth sores, skin sores; or
• signs of tumor cell breakdown --confusion, weakness, muscle cramps, nausea, vomiting, fast or slow heart rate, decreased urination, tingling in your hands and feet or around your mouth.

Your thalidomide doses may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

• fever;
• low blood cell counts;
• headache, dizziness, drowsiness, weakness, tired feeling;
• anxiety, agitation, confusion;
• numbness, tremors, muscle weakness;
• nausea, loss of appetite, constipation;
• weight gain or loss;
• swelling, trouble breathing;
• rash, dry or peeling skin; or
• low calcium level --muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect thalidomide?

Other drugs can affect thalidomide, and certain other medicines may further your increase your risk of blood clots. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your doctor or pharmacist can provide more information about thalidomide.